Research ArticleAdult Brain
Open Access
The Benefits of High Relaxivity for Brain Tumor Imaging: Results of a Multicenter Intraindividual Crossover Comparison of Gadobenate Dimeglumine with Gadoterate Meglumine (The BENEFIT Study)
M. Vaneckova, M. Herman, M.P. Smith, M. Mechl, K.R. Maravilla, J. Weichet, M.V. Spampinato, J. Žižka, F.J. Wippold, J.J. Baima, R. Babbel, E. Bültmann, R.Y. Huang, J.-H. Buhk, A. Bonafé, C. Colosimo, S. Lui, M.A. Kirchin, N. Shen, G. Pirovano and A. Spinazzi
American Journal of Neuroradiology July 2015, DOI: https://doi.org/10.3174/ajnr.A4468
M. Vaneckova
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
M. Herman
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
M.P. Smith
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
M. Mechl
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
K.R. Maravilla
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
J. Weichet
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
M.V. Spampinato
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
J. Žižka
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
F.J. Wippold II
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
J.J. Baima
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
R. Babbel
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
E. Bültmann
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
R.Y. Huang
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
J.-H. Buhk
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
A. Bonafé
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
C. Colosimo
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
S. Lui
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
M.A. Kirchin
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
N. Shen
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
G. Pirovano
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
A. Spinazzi
From the Charles University in Prague (M.V.), First Faculty of Medicine and General University Hospital, Prague, Czech Republic; University Hospital Olomouc (M.H.), Olomouc, Czech Republic; Beth Israel Deaconess Medical Center (M.P.S.), Boston, Massachusetts; Faculty of Medicine (M.M.), University Hospital Brno, Masaryk University, Brno, Czech Republic; MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington; Na Homolce Hospital (J.W.), Prague, Czech Republic; Department of Radiology and Radiological Science (M.V.S.), Medical University of South Carolina, Charleston, South Carolina; University Faculty of Medicine in Hradec Králové (J.Ž.), University Hospital Hradec Králové and Charles University in Prague, Prague, Czech Republic; Mallinckrodt Institute of Radiology (F.J.W.), Washington University School of Medicine, St. Louis, Missouri; Clinical Radiologists, S.C. (J.J.B.), Springfield, Illinois; Good Samaritan Regional Medical Center (R.B.), Corvallis, Oregon; Institute of Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany; Harvard Medical School (R.Y.H.), Brigham and Women's Hospital, Boston, Massachusetts; University Medical Center Hamburg Eppendorf (J.-H.B.), Hamburg, Germany; Hopital Gui de Chauliac (A.B.), Montpellier, France; Policlinico “Agostino Gemelli” (C.C.), Rome, Italy; West China Hospital of Sichuan University (S.L.), Chengdu, Sichuan, China; Global Medical & Regulatory Affairs (M.A.K.), Bracco Imaging S.p.A., Milan, Italy; and Global Medical & Regulatory Affairs (N.S., G.P., A.S.), Bracco Diagnostics, Monroe, New Jersey.
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M. Vaneckova, M. Herman, M.P. Smith, M. Mechl, K.R. Maravilla, J. Weichet, M.V. Spampinato, J. Žižka, F.J. Wippold, J.J. Baima, R. Babbel, E. Bültmann, R.Y. Huang, J.-H. Buhk, A. Bonafé, C. Colosimo, S. Lui, M.A. Kirchin, N. Shen, G. Pirovano, A. Spinazzi
The Benefits of High Relaxivity for Brain Tumor Imaging: Results of a Multicenter Intraindividual Crossover Comparison of Gadobenate Dimeglumine with Gadoterate Meglumine (The BENEFIT Study)
American Journal of Neuroradiology Jul 2015, DOI: 10.3174/ajnr.A4468
The Benefits of High Relaxivity for Brain Tumor Imaging: Results of a Multicenter Intraindividual Crossover Comparison of Gadobenate Dimeglumine with Gadoterate Meglumine (The BENEFIT Study)
M. Vaneckova, M. Herman, M.P. Smith, M. Mechl, K.R. Maravilla, J. Weichet, M.V. Spampinato, J. Žižka, F.J. Wippold, J.J. Baima, R. Babbel, E. Bültmann, R.Y. Huang, J.-H. Buhk, A. Bonafé, C. Colosimo, S. Lui, M.A. Kirchin, N. Shen, G. Pirovano, A. Spinazzi
American Journal of Neuroradiology Jul 2015, DOI: 10.3174/ajnr.A4468
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