Case of the Week
Section Editors: Matylda Machnowska1 and Anvita Pauranik2
1University of Toronto, Toronto, Ontario, Canada
2BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada
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April 20, 2015
Ganglioglioma with Malignant Transformation
- Gangliogliomas are glioneuronal tumors of central nervous system, affecting mainly children and young adults. Malignant transformation is rarely seen.
- Clinical Presentation: Chronic epilepsy refractory to medication
- Common location: Cortical superficial location within the cerebral hemispheres, predilection for the frontal and temporal lobes. Other uncommon sites are reported.
- Key Diagnostic Features: The classic appearance of ganglioglioma is a cystic lesion with a solid enhancing mural nodule, often calcified. "Bizarre" patterns of calcification can be seen.
- DDx:
- Pleomorphic xanthoastrocytoma
- Pilocytic astrocytoma
- Oligodendroglioma
- Rx: Surgical resection
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