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  • Generation and characterization of HLA-A2 transgenic mice expressing the human TCR 1G4 specific for the HLA-A2 restricted NY-ESO-1157-165 tumor-specific peptide

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Immune cell therapies and immune cell engineering
Original research
Generation and characterization of HLA-A2 transgenic mice expressing the human TCR 1G4 specific for the HLA-A2 restricted NY-ESO-1157-165 tumor-specific peptide

Authors

  • Eugene Shenderov MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, UKNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USADepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA PubMed articlesGoogle scholar articles
  • Matheswaran Kandasamy MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, UK PubMed articlesGoogle scholar articles
  • Uzi Gileadi MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, UK PubMed articlesGoogle scholar articles
  • Jili Chen MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, UK PubMed articlesGoogle scholar articles
  • Dawn Shepherd MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, UK PubMed articlesGoogle scholar articles
  • James Gibbs National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Gennaro Prota MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, UK PubMed articlesGoogle scholar articles
  • Jonathan D Silk MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, UKNext Generation Research, Adaptimmune, Abingdon, UK PubMed articlesGoogle scholar articles
  • Jonathan W Yewdell National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Vincenzo Cerundolo MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, UK PubMed articlesGoogle scholar articles

Citation

Shenderov E, Kandasamy M, Gileadi U, et al
Generation and characterization of HLA-A2 transgenic mice expressing the human TCR 1G4 specific for the HLA-A2 restricted NY-ESO-1157-165 tumor-specific peptide
Journal for ImmunoTherapy of Cancer 2021;9:e002544. doi: 10.1136/jitc-2021-002544
Online issue publication 
February 24, 2022

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Copyright information

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.