{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022IhzIAiY9M8f+fnuWB+jXK660k0phJgFNMBY\\\\\\\\\\\\\\\/Fakyn5nO286ePI4CXwNmDtR2upp87oHZAhVJFK7pYy1AmSIqbN7F6NAo0rTK82IRnOQgA9MKUCxukHbC20xB3dfe\\\\\\\\\\\\\\\/dVndldvKVFeA6cRbYn61iEjiN\\\\\\\\\\\\\\\/d8h4ZTOQ14+xKYOJji0qCszSZhjxj+qvLst0\\\\\\\\\\\\\\\/oWrk4trIfCTSkq7+HPguQw\\\\\\\\\\\\\\\/+bVu7WRF0VrX7+Nxy83z\\\\\\\\\\\\\\\/5sNwgxqtUlGpPkqxEh4ivKe1Xi27Ycw5RrekPMAKc+dRp0CfbH3LWkbaVK11arjZMivbQ0jTlgo+DUl8rvC2s605XCACRXvD3dEHu9HlN+dZ3pzWeB0oW7aJyahLEJyOJmcEtKI9GdlcjNq2y+6WImDIVxPFgX711Ls6JBmN9ZESU424B0CA8C0Ub9Krn\\\\\\\\\\\\\\\/R8kZj5BPp0lez2bMBdW7Cln5\\\\\\\\\\\\\\\/Pv8R7ySr+dsETUv\\\\\\\\\\\\\\\/6pjAHmOt9kJKNraxfJnDBp7vKQt884ECMbe5nxhLr5K\\\\\\\\\\\\\\\/oMob2y4\\\\\\\\\\\\\\\/xxDSacr3N18ixJ0Ju1oG4BejQqCX35Ka\\\\\\\\\\\\\\\/1yuPXfNHTjDXjDr\\\\\\\\\\\\\\\/cVMLGzcCswnPQOqkVE6vCwQv3IxkYU5ZvwW3nwdwrJg75u\\\\\\\\\\\\\\\/p4Roim9bMOQL1FQSXmk6e+ga9O\\\\\\\\\\\\\\\/blO\\\\\\\\\\\\\\\/tKBGL\\\\\\\\\\\\\\\/TG0WkPfviaWvVME002fyXAEQhP4vegYgNGieV7kJS0ofIUeavkDehhlIz6sgXRC1kDkARbYw\\\\\\\\\\\\\\\/9sKbZhMqT7wvo\\\\\\\\\\\\\\\/+B6q8OvjDChgZMZd+4\\\\\\\\\\\\\\\/TFBDvapXvffVpr1kMvHdGrO20\\\\\\\\\\\\\\\/BgJ1NXV05NTXnIy\\\\\\\\\\\\\\\/EGvK6sMj\\\\\\\\\\\\\\\/B9x3jz3OhIa16OJ9yKm6Q\\\\\\\\\\\\\\\/4e38gLuWa0HxJlpdx6qevZut9oWvz7V\\\\\\\\\\\\\\\/YkX0dV+AH7KblctfHdpEo\\\\\\\\\\\\\\\/KsYU+v79AHa8SdgYkORJrX1Ps1NYTeOCDxH8gj8rcOqL0iD6Cq\\\\\\\\\\\\\\\/UFJm\\\\\\\\\\\\\\\/SgHOr6w25do9RYqIIEpIlUqWPD4pKIjOIw9oQWzcLVP0FfL7I2\\\\\\\\\\\\\\\/L+k74fCKx4CsOygULi5nMa4Vd3T+1YWqT+oa780S4Aaw6V+ZTzqB7FrPXZRot7DcvMmznPW2YP9cgJpGCs8v4LMMmpAHrJtucNo4cy87lPfZXhfuFd0cpB5KgvJlQIk2m0ZjS2t9ESPqJ81PyOs\\\\\\\\\\\\\\\/lZvSsH\\\\\\\\\\\\\\\/1ulyp3LpQLyzpBfdCec6cjVvZBOsCm31qSF9Ea\\\\\\\\\\\\\\\/tltHCadMJiLMyqAuZz6iXbUlvSns+ExQ6DGTwvlFE32Hc6bgOVBcAgRJFMD5oWJ9fe8xNjcFLcdC9TCBDNLkodTMgbP7jvZZwuVuMg6Zc4Qho5Ele1J3Icyirn4z+dJwS4wH2ahq\\\\\\\\\\\\\\\/SBpZkbKT0RuE8ngay61Ftq0cGJ7UiIRqy0xSmKv9keGDNSKXuK8Q7BoHrmvhrqOSh4jpgwb+NPuTlc9xgUqyig2EjG4Sh2QirfDqttNoeTihadZ7VTpQKyfLqH7yiq1yd+cucnyXDz1\\\\\\\\\\\\\\\/9TFGgbMH+ish6idjdALxq\\\\\\\\\\\\\\\/hr5HX4qzkYRh5t8zDPYadHJuQHrHlx0JVvoy4abQPpw9Bz1loiBURT1hLoiQAfv75a1IOp7dj5BPTjfoIn037aEhjaookJyPpGifRfPcbYFvOYy10DP1Kc0xutw+kJI4xnRGiNlmzgEyybuep9DJ+wm5zZiANCZa2wzeS0WtAs7lglCONT2F9BGs7oW\\\\\\\\\\\\\\\/Q0QowYIrRKQbO4YxvxCh2KyCt2e6wtGgZTDNUPrLC4US4gYY6Gbyj54YTuCezqyrkL\\\\\\\\\\\\\\\/+8b8+SCX54GmaUaQIgU3nugFhvoZyROjTsiIZXHZL0qauWhm3j0iDsvBqVklXy4hd5Nuro5wP8eJ9IrA0JozPUz2c+cntFgt\\\\\\\\\\\\\\\/P3+AKBZ4575j3eSCJPVz\\\\\\\\\\\\\\\/xbVQ555e+ypKbdZXQnuqDyv5uoYtpfT6PsUmeEvYqzJ0pHSEyeXM5Hhv3oOWNjsgcYCm9eWZ6N3Hr6ZfW4Oaw2ZRgo+FNlnDIgSHGN6BT9uthEY1lEVl7ztz2lcU82Kgho1SQf1KVcfC\\\\\\\\\\\\\\\/yWTgamuSTg02SjAGnuwgpR+o\\\\\\\\\\\\\\\/TT0kcVaVk6IhNDGFfiTDWlMbBeWERajZsqiNfEIeYvROtdUtGFqjD9++uklulCMEkKVmJarVrmaiazC0ZU+N52XNq7+WpRydEn91hzeGSNYHnKTGahDUtCXwbSYS6FTleT\\\\\\\\\\\\\\\/7va8DDgZ8p7l7AW8Pm4XPIDAlprKFkTAVAksCLU1441CjkmKfmhibv0EVvmwSeK4fPnDqKuaOa8ny1tfDH5Pixm5206peTuy8+KGWDjfVaeYXWY4ZaiOM0iyUZ6TFVqmrpYhUXJLQRGrMSFULw9P4W6wLh5SXn3qCa7COOJ9L+sRiO3oXJ2EU\\\\\\\\\\\\\\\/rs2QYjQX0g8qXj6xlM3OpzptBnlWlF5sGbbAVXVB1B3orNbFffG4AeCOZj4FQ\\\\\\\\\\\\\\\/MKNGBVX\\\\\\\\\\\\\\\/Nf9qHa1PhaFIJbw+UPXhpruActCI61NNuwCdnk95uqTD50MC55JoS365a\\\\\\\\\\\\\\\/HeBn9Go5cb6\\\\\\\\\\\\\\\/AC0zvsPQi5A\\\\\\\\\\\\\\\/VpmylQGFf9BnAdaQMywicaq\\\\\\\\\\\\\\\/BiqBW73JR0CO\\\\\\\\\\\\\\\/oGTNsP\\\\\\\\\\\\\\\/cAfVD03JuqSYUINamplQBaQQ3uYyGXv3cAffu9qGKbtJXiSyb7+NjQs7Wl3O1hZCAjUXnqhCDs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022j3v+CUDWpmzW+rdb4n\\\\\\\\\\\\\\\/mCg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c75d54689f8c7f28cc71e9bffa400fe51aabb2a5f648504dd8676146951fee21\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/6\\\/e002544.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/6\\\/e002544.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002544\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002544\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002544\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}