Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes

John A Ligon; Woonyoung Choi; Gady Cojocaru; Wei Fu; Emily Han-Chung Hsiue; Teniola F Oke; Nicholas Siegel; Megan H Fong; Brian Ladle; Christine A Pratilas; Carol D Morris; Adam Levin; Daniel S Rhee; Christian F Meyer; Ada J Tam; Richard Blosser; Elizabeth D Thompson; Aditya Suru; David McConkey; Franck Housseau; Robert Anders; Drew M Pardoll; Nicolas Llosa

doi:10.1136/jitc-2020-001772

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Immunotherapy biomarkers

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Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes

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John A Ligon Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USAPediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA PubMed articles Google scholar articles
Woonyoung Choi Greenberg Bladder Cancer Institute and Brady Urological Institute, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Gady Cojocaru Greenberg Bladder Cancer Institute and Brady Urological Institute, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Wei Fu Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Emily Han-Chung Hsiue Cellular and Molecular Medicine Program, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Teniola F Oke Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Nicholas Siegel Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Megan H Fong Greenberg Bladder Cancer Institute and Brady Urological Institute, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Brian Ladle Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Christine A Pratilas Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Carol D Morris Division of Orthopaedic Oncology, Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Adam Levin Division of Orthopaedic Oncology, Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Daniel S Rhee Surgery, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Christian F Meyer Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Ada J Tam Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Richard Blosser Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Elizabeth D Thompson Pathology, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Aditya Suru Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
David McConkey Greenberg Bladder Cancer Institute and Brady Urological Institute, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Franck Housseau Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Robert Anders Pathology, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Drew M Pardoll Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Nicolas Llosa Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles

Citation

Ligon JA, Choi W, Cojocaru G, et al

Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes

Journal for ImmunoTherapy of Cancer 2021;9:e001772. doi: 10.1136/jitc-2020-001772

Online issue publication

February 07, 2022

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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