{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022KQFElyJBFMQ9I4eipngHHBil4FHw9tBBsuLP8nSNJ7V6H7rXzc2p1r7D9I+3OqQE4UQWO5PgMV2PNg4RaBMJ2HjExKuHB86TNVPe1\\\\\\\\\\\\\\\/akAc2g1KM85zkdVjoM7fXoS9kJJrffug3CNPUr1zQks+84gF8w3tHH\\\\\\\\\\\\\\\/3x4FQ3mag7GscwsQ+6S53kJ1RUaDedjBBAe0u9HybBAvqF3XbdPLwpDPbgBXEkMlDol5ZMSihK4F\\\\\\\\\\\\\\\/1DryvXDv++SWGKvKMj+RmrxiO\\\\\\\\\\\\\\\/u7lKpjTInaZDPQp7b74iODjxtDEc1Q7iFVDll7amxBK6w6Ok5jmQitCs1g8dc8oiui9Ilb1at\\\\\\\\\\\\\\\/J5HqhLNXjp+wCuL8DYFa2t4H31WSNf\\\\\\\\\\\\\\\/7HKycnLT9b7Nt5yxCrd4KYaxrrD0ZbMLjcZU7Na4rP5JygxIwqCSjprGcuD1hn6ofwD5eVStqcQAxOGLaa9gGqbery976S1pBRRVlglv6eJsrQg1OV9wJ0zzEDvvwZMPNjpuqACBQhEeOyYXExfYoiOO0tEscnc38FfviApehevKxMwYeM6ZrSZt3NtrmKmxec1s+AMYfbrlVaBCHO5sPpWPHR6eDmmojrY+sR5ryi6gdgX8B3\\\\\\\\\\\\\\\/NshDahHS6leHcnClvW0PeRq9Vt1kPuMM1rCrYJ5QXXAJVQRk6SOnO8xm50odwmSqqJ9mFqUxgSdvYFksMv8fyZZ0ke31D9w\\\\\\\\\\\\\\\/LjZqmi\\\\\\\\\\\\\\\/S91WQa25nh4rAhYa4XtjCWCxy6gVyGhcxstvxDEu5QMGtXRJMbGtSxINzQg0KyHsU8+MKRB1JTnb8tu8ArAYzK7\\\\\\\\\\\\\\\/Nz\\\\\\\\\\\\\\\/3cZ0Eet7zWesluoOcTR1Hrr9teIJhTfJEj0oI+KuoSeE3WvV7C35y1UvTMmnYdPZJ30J03AMyXPyILimDIGuH8TdbvANQJituZNNj612GJcx8EkkoN52jAjhSQ3KAYy9W7TYgePZ+GJFCOvF7Ph6n8KXYsj\\\\\\\\\\\\\\\/Vky5mA0ukQpp+Qq0ZIDTMNpMcSRyfEsD46bv+DV+Zk1PbPlROl0vn6sCf5gjuBbs6N58p7TsJ\\\\\\\\\\\\\\\/BdzvxMszsb7GmSDOX3tHd4FwwmQkyKpdg3wTUl7Q0AdXrR6bGtJg3jzzeEM\\\\\\\\\\\\\\\/5Z8AgFegR15ckxCaZDN0trI18\\\\\\\\\\\\\\\/cXM+00y4k2nld0aMtXrGzY7hwFwBe3QFr5qiayaYeOzryr\\\\\\\\\\\\\\\/844ZIV8rDzNVw9Nj7lW+MMRKxAPbPn0Lw5Mm+AQ6IKEsO09yk29mJcIq6oAMEREFzGmsFWMI9kjvr7k2eeTAtH9UNtQAskWLLLG6I+NfUqiLwJsdpZyGMBhYmA11F9vESLKR6Ty2DqVTDmbO4FHEywgMptuoThQSEnyBCx5Iy20opmcIgSvC3dMB+LqBVf2gGJepdkWafmCaVS+RnPi4gLHUQCvlhMdvrP75n\\\\\\\\\\\\\\\/5CBEUQcrbGbjUpBjB+Dc1sNAQwVxkcSGplbXpVAPZUOXq1Id\\\\\\\\\\\\\\\/RaFIHqKYNwVTgcYPHo\\\\\\\\\\\\\\\/8DnCp2sGBC15nXv8terJNvj3ocKlmnGWqWV9gQ4dCc+RIVHKutrFgl7dDbsnTFnhv739eDO3n1EEpHEnxC\\\\\\\\\\\\\\\/PaDYgR56YPHcJfKXHjUT1tfs2e\\\\\\\\\\\\\\\/B0qyJouB2UMAlev0wGOc3bLGX0L\\\\\\\\\\\\\\\/ZQE1p470UyoYFPuuDErre3lDZupmuEGaMdrLmIN21wa1Q3UjW58yEHbJcowTXNYITWpFB2yAqH53v7tLcYc\\\\\\\\\\\\\\\/sgSgmMqOzmRBZu1vtYQiUyjV9ICI+iQy+2KDQBxlI32L3Yt5wlWhMSlCC0PACcQz3RBqD1hlyD1ujpcXK7hdy1O2lMFCBAGVf+yChJ\\\\\\\\\\\\\\\/GNUV3frUjsI1smCm\\\\\\\\\\\\\\\/Nyn0XXhIGy1T6YypCxa0zMcUvd0ij24o10nHEubkraa0BlTtkH+qPB0qtAsSexyQez9DcK+jPBk7BlpmuYP\\\\\\\\\\\\\\\/kO2NnTw3gL0IyrD4O+ZYSyumtYY2OppHWVWtgTbwQ7alYdKf9djvxG++U9d5bZiz7ghHCvDlbdx5Vc189WuhMwPQl15lH4FZktxpgoSi3mGcd5NDOBKUdeesMOyuycWX5SJ76WZ+5+SnpSZMoRKlZ5yibfPzuWjxaXEIrSQVT1BV1Gj5MyyBV3ZcevlsTV3SYQVh\\\\\\\\\\\\\\\/7YRGlse5ZebxuuGPqGaQF4k5mFio+6FroVct8WR+NGQRO6713ZQcR4RdyddMj3c9NJoYmb9NP2JrBEA5ZfZBf30dNCH9BPOZXA8Que8DnzuqndghTqNXvhTk6xLPSV+9Dhao7EpyZN66FCBI6FrDL9epiVZNMy89zD\\\\\\\\\\\\\\\/KR3WygHHK8h3XnBo2RnvYh82\\\\\\\\\\\\\\\/BLFS6Hu0tw+OuY2s7LDj5HfUbej0hY5OUDcuVyyBTBkE1vnlWKz6GrPc2yrsBMC5dfBmoDQDqcruYOHofGUl2of7SBbsF\\\\\\\\\\\\\\\/y7SwxEvJcEmgd13sGqfU+H1Iq\\\\\\\\\\\\\\\/a+r9sK1wv\\\\\\\\\\\\\\\/AHDdvaITV\\\\\\\\\\\\\\\/JWd8YW\\\\\\\\\\\\\\\/isx\\\\\\\\\\\\\\\/9WL8iq2AxS9rpwN5xGxurAu4VBZ7mAPRv3v+YwrCKmeyvEfSc+27ioMDWszWtJCvvvAXyFYEdg9Ihfrio9bl8y+\\\\\\\\\\\\\\\/WQtNI7D+8yQBmb+ItVef65oNFl9JoliDpGK45Of0v7ZZrFHIjWi7ldmSST8s6tWRtQj8Ys8FIxqm+A1egUrGedYwQM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022O0ew\\\\\\\\\\\\\\\/xFfZV9zHRZ4yAFV+Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d040083e268aa40622ffd3018855a6bd60f26be82d9f25c3ee58bc280a3a677f\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/5\\\/e001772.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/5\\\/e001772.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001772\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001772\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001772\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}