709 Exosome surface display of IL-12 results in tumor-retained pharmacology with superior potency and limited systemic exposure

Nuruddeen Lewis; Chang Ling Sia; Katherine Kirwin; Sonya Haupt; Gauri Mahimkar; Tong Zi; Ke Xu; Kevin Dooley; Su Chul Jang; Bryan Choi; Andrew Grube; Christine McCoy; Jorge Sanchez-Salazar; Michael Doherty; Scott Estes; Kyriakos Economides; Douglas Williams; Sriram Sathyanaryanan

doi:10.1136/jitc-2020-SITC2020.0709

Article info

Regular and young investigator award abstracts

Novel single-agent immunotherapies

709 Exosome surface display of IL-12 results in tumor-retained pharmacology with superior potency and limited systemic exposure

Authors

Nuruddeen Lewis Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Chang Ling Sia Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Katherine Kirwin Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Sonya Haupt Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Gauri Mahimkar Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Tong Zi Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Ke Xu Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Kevin Dooley Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Su Chul Jang Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Bryan Choi Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Andrew Grube Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Christine McCoy Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Jorge Sanchez-Salazar Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Michael Doherty Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Scott Estes Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Kyriakos Economides Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Douglas Williams Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles
Sriram Sathyanaryanan Codiak BiSciences, Andover, MA, USA PubMed articles Google scholar articles

Citation

Lewis N, Sia CL, Kirwin K, et al

709 Exosome surface display of IL-12 results in tumor-retained pharmacology with superior potency and limited systemic exposure

Journal for ImmunoTherapy of Cancer 2020;8:doi: 10.1136/jitc-2020-SITC2020.0709

Online issue publication

December 12, 2020

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password