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Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer

Authors

  • Elena Bruni Unit of Clinical and Experimental ImmunologyHumanitas Clinical and Research Center – IRCCS Via Alessandro Manzoni, 56, Rozzano Milan Italy Department of Medical Biotechnologies and Translational Medicine (BioMeTra)University of Milan Milan Italy PubMed articlesGoogle scholar articles
  • Valentina Cazzetta Unit of Clinical and Experimental ImmunologyHumanitas Clinical and Research Center – IRCCS Via Alessandro Manzoni, 56, Rozzano Milan Italy Department of Medical Biotechnologies and Translational Medicine (BioMeTra)University of Milan Milan Italy PubMed articlesGoogle scholar articles
  • Matteo Donadon Department of Hepatobiliary and General SurgeryHumanitas University, Humanitas Clinical and Research Center – IRCCS Rozzano Milan Italy PubMed articlesGoogle scholar articles
  • Matteo Cimino Department of Hepatobiliary and General SurgeryHumanitas University, Humanitas Clinical and Research Center – IRCCS Rozzano Milan Italy PubMed articlesGoogle scholar articles
  • Guido Torzilli Department of Hepatobiliary and General SurgeryHumanitas University, Humanitas Clinical and Research Center – IRCCS Rozzano Milan Italy PubMed articlesGoogle scholar articles
  • Gianmarco Spata Unit of Clinical and Experimental ImmunologyHumanitas Clinical and Research Center – IRCCS Via Alessandro Manzoni, 56, Rozzano Milan Italy Department of Medical Biotechnologies and Translational Medicine (BioMeTra)University of Milan Milan Italy PubMed articlesGoogle scholar articles
  • Gloria Leonardi Unit of Clinical and Experimental ImmunologyHumanitas Clinical and Research Center – IRCCS Via Alessandro Manzoni, 56, Rozzano Milan Italy Department of Medical Biotechnologies and Translational Medicine (BioMeTra)University of Milan Milan Italy PubMed articlesGoogle scholar articles
  • Francesco Dieli Central Laboratory for Advanced Diagnosis and Biomedical Research Palermo Italy Department of Biomedicine, Neurosciences and Advances Diagnostics (Bi.N.D.)University of Palermo Palermo Italy PubMed articlesGoogle scholar articles
  • Joanna Mikulak Unit of Clinical and Experimental ImmunologyHumanitas Clinical and Research Center – IRCCS Via Alessandro Manzoni, 56, Rozzano Milan Italy Department of Medical Biotechnologies and Translational Medicine (BioMeTra)University of Milan Milan Italy PubMed articlesGoogle scholar articles
  • Domenico Mavilio Unit of Clinical and Experimental ImmunologyHumanitas Clinical and Research Center – IRCCS Via Alessandro Manzoni, 56, Rozzano Milan Italy Department of Medical Biotechnologies and Translational Medicine (BioMeTra)University of Milan Milan Italy PubMed articlesGoogle scholar articles

Citation

Bruni E, Cazzetta V, Donadon M, et al
Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer
Journal for ImmunoTherapy of Cancer 2019;7:347. doi: 10.1186/s40425-019-0825-4
Online issue publication 
January 08, 2022

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© The Author(s). Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.