{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00229Nog7zhEGzSKXfF1Rq8GJjxkihTR90kxLlOLllfvhocyZzEKtyl5KUnL2qVBtK2kyXcWLjPybt0KbZTnragsA846tBrwtSbWSquC8iqcTkm67YyVkQP98wrIPXohP2rNz7yfU4FjV+pUtMqNc1P05\\\\\\\\\\\\\\\/VmnvWIe4ZZxttsKuL7Pq5rIWwiLZuWtVqcrnEKG\\\\\\\\\\\\\\\/0fYnhGiOrEF9X55qzWq9O\\\\\\\\\\\\\\\/4FqRLggOBdVAdMU4IzX17qGVBfRYbroKzySytoAnFBuITfr8WhXoCJkbgnxf\\\\\\\\\\\\\\\/p9MUAvf7Q0Am7FmWCV7HPF+9Ym8W1Ra2ajokF34jP2uxTObsG01+9gBpOnGrLZj3NuxUKrnD7wHdkdy18lUc4br3q7gdeIeA4yTvlx+o5rvkmIh+RrSxvMhBU9saiJQWJLT4\\\\\\\\\\\\\\\/2\\\\\\\\\\\\\\\/YgCB6butwmgjQMHvZN6ZRW1CsoiA3sVpXtQK6dTnEhgwQinJin2aMiiWrAf6TiG5N8CnoiAIvc2IlTnBh1g+zgMsljSYJoPbuC8p5F96w5NMJDxLLhrXeOOw1x0YBzvhZCLooJOdQmfE2n7FwT+N0qmHzmSw5xhbFb9Ff6o9VO5Ha5yNWJVUYbrH7KRablsc\\\\\\\\\\\\\\\/Jnz5then4gurxJHWoiacpvZuxRM8reV\\\\\\\\\\\\\\\/xCkQqWeRDx9ClE4ECcSzpoBaGrJYCvxgKtBAn96dNUMht0MqS9rVDVPL9tMYWqw0u5HX2tVzQhgcSFTc0Rmvr6UxNyGsTz6cbFyhm2ZKvafujA5pry0LYlemcIx1CvVDIrE\\\\\\\\\\\\\\\/mc88KdzRip5l1lqDrWjMqjSpMV46BhuEao7ftiBBTwaxTiKxLA+EJHHVN+eziAGWPak+q0JIFtP\\\\\\\\\\\\\\\/C\\\\\\\\\\\\\\\/I1dHhyrSJxf7Uj8sx6\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/dGu7vQYsj8tflSjKE+5mio6jcsgBarak+LWzC8Ibsfra1KPOgcVgj5Trn\\\\\\\\\\\\\\\/NPo5\\\\\\\\\\\\\\\/SCP7hsZ6d+9Dn1efYDfAbU1wOJguBpdAhB1AIZfSRZZwuGavU49EnzWjCRsKo8E1T9QCiCw1YSr5JAPkbkw0qlUsVRYRoIZqfsF0d\\\\\\\\\\\\\\\/Yl6rEQ4+yoJ7JEieizM3pBiD4+6lwc5YWS9w8jDLUiCKTU6Zt26PLli8Y+7Rl40RXsGAt464aovRVTeqKrnZvL2nqtqc5xQx\\\\\\\\\\\\\\\/mKxAzed8jfDQG7DHw2rjPbgLQx3lDjl\\\\\\\\\\\\\\\/KqLpmQ1oaeW+4Lu8mEmlrVsr7i\\\\\\\\\\\\\\\/4qtG0q1tlLIgELgqJncStTmMCcBgYaNZycd5OcbR82dvB1WE39a+mbIjam+chxtir6uvyS0VhItYAFh6Eb2jcXnZBAUuK\\\\\\\\\\\\\\\/QUp9lNev9MGgAbnamFm\\\\\\\\\\\\\\\/6sa6EuEcV54xbasUUrDN0wrmejKCVLLsC4pb1kxJJpGg8B0w3XIiX8cAYcClneIWA0LKVqBIWVWQEZ666E\\\\\\\\\\\\\\\/6JM9po91obXy246xfTTwUE84SnMJQ\\\\\\\\\\\\\\\/EnmUsNhr7V9J+NUX61udVR6taDrQeVeRvFoanYo6Uc\\\\\\\\\\\\\\\/iDlzg6lTG3zXDJT7tIHLDuxqfj2Bq6rCFBhw9OZJIVTHSOh4tztSXXJwr7gKV6BXwbMA3TpJRPqIp1WIo9scdDHPlNvetzXATkDikgQp5HMyebu8R490o+bI\\\\\\\\\\\\\\\/QAcpdtTstH3SYbP+YKQd4I3xR8rmdBnlZmi4YHzeun0qstHuh7Evf2ZuKxCAY39maMuh0Mo\\\\\\\\\\\\\\\/BuTeJnP+IkNEywe5ZRRz+AT+w7SnZeborANpi9GUYcYxgfxt4tw9vYXpdOHmX5btDAs46XO9fb8m384Qm6W1aFKVtR2O5eDazETBe2ZOQZ6R8AqSysez0cQfENBIyHVCHGNAM9VOyDZIfN21Ukpn6DH5vxOaneTdgSuhaY0S75Vjmd5KxrNr5IPIzipiTVYcS2M1Qlsrb2UeriqGvs6u5OMGnR9Rn96ZdhIwaR2N6AFwQ0pA\\\\\\\\\\\\\\\/Gb7BZn+RF2twCYdHLEuLmWLomjcJOv7q\\\\\\\\\\\\\\\/59QtaWcqZ4w2JlfPGTLFN1e4h6xdneC9ZSy7g8EDvGOQ0prAHY28uaFyEo8C0quqxWjNCLoqEsr2Uvn8uKPfWt5fiBl01msYd7omzy\\\\\\\\\\\\\\\/STIz6zuMMZgeSOgds+\\\\\\\\\\\\\\\/AtN3xwvgxrq0FVj5w7G2r62NTlV4My9R8q97NWuadcjkPAXYFSokI+c4Okp9rJAhULnt7RqfmniE5hu33F3jGQbD1rlzaXRgpx6yBbvkqRV8sClLrtqrLtZpH8S+t5iUCNAXlFzHw7tOBZgEdxbRixDT4FXUO+MC4JGJMX4dfpsUk5PhBE3cM5uVlbWay7mGZieeo2UWm\\\\\\\\\\\\\\\/+zP1WSEp3\\\\\\\\\\\\\\\/s2VUAwJjeteroMrTCLQOL9cZSr82MG\\\\\\\\\\\\\\\/8ajGJ0nLCrWfVrp3LsNea\\\\\\\\\\\\\\\/3o06AZmLcE5wcKFa0ox8mdHxOtQg8ZgwG0q3xKUVoFfl4YDRUQFOHz74g6Aiy1H+uUfLNB0V75\\\\\\\\\\\\\\\/IckpUI3hIPwNz3Fc97Kt8c5gUzDz\\\\\\\\\\\\\\\/G\\\\\\\\\\\\\\\/ysIgmFZ4+C1z6A7TXXUUaPvCnyOVgRWfHLFJkzXBKC062chqIz9MFJEnbaIeUgiyBdWOTwq3DIvXL3O6WmgRnydEoMUC3daJQLxN1tY7aZkgq5+pSWCb99ZN+8dOXCYfQKdW7aD241tWcJzLUXy+NtFUhRONTw2qMLccVZ8Z174qHFxGtyAwdXWBzM7MkpiElwfXc\\\\\\\\\\\\\\\/N2aMhGu9uYILxVtFPItYOMWURZkFngPyH\\\\\\\\\\\\\\\/98KH3uZpRnJVXbzFJhKSUq3kDHcdsF2gtmSoaHNLbYkIOgsFrAMWrrHXQjxerNaCCJWeCddsypmcXHpbMT8Q0\\\\\\\\\\\\\\\/OmXUfoUNBIZLSyRGvIVdNULRaujhWWV\\\\\\\\\\\\\\\/Pp3ZNcfWDGZkNohLtNLYukUx1iIc6rX5WA1k2K8ear9ghu\\\\\\\\\\\\\\\/1gEO70aku6qWeoADUJacit3m3P9XccNyJAV\\\\\\\\\\\\\\\/OkM\\\\\\\\\\\\\\\/4Rx4G2+AJfQGTPI18LGRV1GC9oUIPJIY0tSSBZWWumbanYFGN9A==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022xxRjd4FG1yanlTBf99hC\\\\\\\\\\\\\\\/g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223b505a308ad5114e47249ee53bf31b6ee34045b2236beb981c618b869a921427\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/347.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/347.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EElena\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBruni\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-1\u0022\u003EUnit of Clinical and Experimental Immunology\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003EHumanitas Clinical and Research Center \u0026acirc;\u0026#128;\u0026#147; IRCCS\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003EVia Alessandro Manzoni, 56, Rozzano\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-3\u0022\u003EDepartment of Medical Biotechnologies and Translational Medicine (BioMeTra)\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-4\u0022\u003EUniversity of Milan\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Bruni%20E\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AElena%20Bruni%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EValentina\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ECazzetta\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-1\u0022\u003EUnit of Clinical and Experimental Immunology\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003EHumanitas Clinical and Research Center \u0026acirc;\u0026#128;\u0026#147; IRCCS\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003EVia Alessandro Manzoni, 56, Rozzano\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-3\u0022\u003EDepartment of Medical Biotechnologies and Translational Medicine (BioMeTra)\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-4\u0022\u003EUniversity of Milan\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Cazzetta%20V\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AValentina%20Cazzetta%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMatteo\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EDonadon\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDepartment of Hepatobiliary and General Surgery\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-6\u0022\u003EHumanitas University, Humanitas Clinical and Research Center \u0026acirc;\u0026#128;\u0026#147; IRCCS\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003ERozzano\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Donadon%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMatteo%20Donadon%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMatteo\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ECimino\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDepartment of Hepatobiliary and General Surgery\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-6\u0022\u003EHumanitas University, Humanitas Clinical and Research Center \u0026acirc;\u0026#128;\u0026#147; IRCCS\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003ERozzano\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Cimino%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMatteo%20Cimino%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGuido\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ETorzilli\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDepartment of Hepatobiliary and General Surgery\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-6\u0022\u003EHumanitas University, Humanitas Clinical and Research Center \u0026acirc;\u0026#128;\u0026#147; IRCCS\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003ERozzano\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Torzilli%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGuido%20Torzilli%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGianmarco\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESpata\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-1\u0022\u003EUnit of Clinical and Experimental Immunology\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003EHumanitas Clinical and Research Center \u0026acirc;\u0026#128;\u0026#147; IRCCS\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003EVia Alessandro Manzoni, 56, Rozzano\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-3\u0022\u003EDepartment of Medical Biotechnologies and Translational Medicine (BioMeTra)\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-4\u0022\u003EUniversity of Milan\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Spata%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGianmarco%20Spata%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGloria\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELeonardi\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-1\u0022\u003EUnit of Clinical and Experimental Immunology\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003EHumanitas Clinical and Research Center \u0026acirc;\u0026#128;\u0026#147; IRCCS\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003EVia Alessandro Manzoni, 56, Rozzano\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-3\u0022\u003EDepartment of Medical Biotechnologies and Translational Medicine (BioMeTra)\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-4\u0022\u003EUniversity of Milan\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Leonardi%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGloria%20Leonardi%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EFrancesco\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EDieli\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-7\u0022\u003ECentral Laboratory for Advanced Diagnosis and Biomedical Research\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EPalermo\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-8\u0022\u003EDepartment of Biomedicine, Neurosciences and Advances Diagnostics (Bi.N.D.)\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-9\u0022\u003EUniversity of Palermo\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EPalermo\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Dieli%20F\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AFrancesco%20Dieli%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJoanna\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMikulak\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-1\u0022\u003EUnit of Clinical and Experimental Immunology\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003EHumanitas Clinical and Research Center \u0026acirc;\u0026#128;\u0026#147; IRCCS\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003EVia Alessandro Manzoni, 56, Rozzano\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-3\u0022\u003EDepartment of Medical Biotechnologies and Translational Medicine (BioMeTra)\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-4\u0022\u003EUniversity of Milan\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Mikulak%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJoanna%20Mikulak%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EDomenico\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMavilio\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-1\u0022\u003EUnit of Clinical and Experimental Immunology\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003EHumanitas Clinical and Research Center \u0026acirc;\u0026#128;\u0026#147; IRCCS\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003EVia Alessandro Manzoni, 56, Rozzano\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-3\u0022\u003EDepartment of Medical Biotechnologies and Translational Medicine (BioMeTra)\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-4\u0022\u003EUniversity of Milan\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMilan\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022IT\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0001-6147-0952\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Mavilio%20D\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ADomenico%20Mavilio%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node11925\u0022 data-node-nid=\u002211925\u0022 id=\u0022node-11925--22117734544\u0022 data-pisa=\u0022jitc;7\/1\/347\u0022 data-pisa-master=\u0022jitc;10.1186\/s40425-019-0825-4\u0022 data-apath=\u0022\/jitc\/7\/1\/347.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EBruni\u003C\/span\u003E E\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ECazzetta\u003C\/span\u003E V\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EDonadon\u003C\/span\u003E M\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EChemotherapy accelerates immune-senescence and functional impairments of V\u0026Icirc;\u0026acute;2\u003Csup\u003Epos\u003C\/sup\u003E T cells in elderly patients affected by liver metastatic colorectal cancer\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2019;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E7:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003E347. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1186\/s40425-019-0825-4 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EJanuary 08, 2022\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; The Author(s).\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-2\u0022\u003E\n\u003Cspan class=\u0022nlm-bold\u0022\u003EOpen Access\u003C\/span\u003EThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by\/4.0\/\u003C\/a\u003E), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-hwp-id=\u0022ext-link-2\u0022 href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u003C\/a\u003E) applies to the data made available in this article, unless otherwise stated.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}