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Research ArticleNeurovascular/Stroke Imaging

Hyperperfusion and Blood-Brain Barrier Disruption beyond the Diffusion-Restricted Infarct 1 Day after Successful Mechanical Thrombectomy

Matthias A. Mutke, Arne Potreck, Markus A. Möhlenbruch, Sabine Heiland, Sibu Mundiyanapurath, Mirko Pham, Martin Bendszus and Angelika Hoffmann
American Journal of Neuroradiology May 2025, 46 (5) 908-914; DOI: https://doi.org/10.3174/ajnr.A8602
Matthias A. Mutke
aFrom the Department of Neuroradiology (M.A. Mutke, A.P., M.A. Möhlenbruch, S.H., M.B., A.H.), Heidelberg University Hospital, Heidelberg, Germany
bDivision of Neuroradiology (M.A. Mutke), Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland
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Arne Potreck
aFrom the Department of Neuroradiology (M.A. Mutke, A.P., M.A. Möhlenbruch, S.H., M.B., A.H.), Heidelberg University Hospital, Heidelberg, Germany
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Markus A. Möhlenbruch
aFrom the Department of Neuroradiology (M.A. Mutke, A.P., M.A. Möhlenbruch, S.H., M.B., A.H.), Heidelberg University Hospital, Heidelberg, Germany
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Sabine Heiland
aFrom the Department of Neuroradiology (M.A. Mutke, A.P., M.A. Möhlenbruch, S.H., M.B., A.H.), Heidelberg University Hospital, Heidelberg, Germany
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Sibu Mundiyanapurath
cDepartment of Neurology (S.M.), Heidelberg University Hospital, Heidelberg, Germany
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Mirko Pham
dDepartment of Neuroradiology (M.P.), Würzburg University Hospital, Würzburg, Germany
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Martin Bendszus
aFrom the Department of Neuroradiology (M.A. Mutke, A.P., M.A. Möhlenbruch, S.H., M.B., A.H.), Heidelberg University Hospital, Heidelberg, Germany
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Angelika Hoffmann
aFrom the Department of Neuroradiology (M.A. Mutke, A.P., M.A. Möhlenbruch, S.H., M.B., A.H.), Heidelberg University Hospital, Heidelberg, Germany
eUniversity Institute of Diagnostic and Interventional Neuroradiology (A.H.), University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
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References

  1. 1.↵
    1. Dornbos D,
    2. Ding Y
    . Reperfusion injury in the age of revascularization. Brain Circ 2018;4:40–42 doi:10.4103/bc.bc_5_18 pmid:30276335
    CrossRefPubMed
  2. 2.↵
    1. Potreck A,
    2. Mutke MA,
    3. Weyland CS, et al
    . Combined perfusion and permeability imaging reveals different pathophysiologic tissue responses after successful thrombectomy. Transl Stroke Res 2021;12:799–807 doi:10.1007/s12975-020-00885-y pmid:33432454
    CrossRefPubMed
  3. 3.↵
    1. Ng FC,
    2. Churilov L,
    3. Yassi N, et al
    . Prevalence and significance of impaired microvascular tissue reperfusion despite macrovascular angiographic reperfusion (no-reflow). Neurology 2022;98:e790–801 doi:10.1212/WNL.0000000000013210 pmid:34906976
    Abstract/FREE Full Text
  4. 4.↵
    1. Shimonaga K,
    2. Matsushige T,
    3. Hosogai M, et al
    . Hyperperfusion after endovascular reperfusion therapy for acute ischemic stroke. J Stroke Cerebrovasc Dis 2019;28:1212–18 doi:10.1016/j.jstrokecerebrovasdis.2019.01.007 pmid:30704865
    CrossRefPubMed
  5. 5.↵
    1. Shan-Shan Lu,
    2. Yue-Zhou Cao,
    3. Chun-Qiu Su, et al
    . Hyperperfusion on arterial spin labeling MRI predicts the 90-day functional outcome after mechanical thrombectomy in ischemic stroke. J Magn Reson Imaging 2021;53:1815–22 doi:10.1002/jmri.27455 pmid:33300253
    CrossRefPubMed
  6. 6.↵
    1. Yu S,
    2. Liebeskind DS,
    3. Dua S, et al
    ; UCLA Stroke Investigators. Postischemic hyperperfusion on arterial spin labeled perfusion MRI is linked to hemorrhagic transformation in stroke. J Cereb Blood Flow Metab 2015;35:630–37 doi:10.1038/jcbfm.2014.238 pmid:25564233
    CrossRefPubMed
  7. 7.↵
    1. Bhaskar S,
    2. Bivard A,
    3. Stanwell P, et al
    . Baseline collateral status and infarct topography in post-ischaemic perilesional hyperperfusion: an arterial spin labelling study. J Cereb Blood Flow Metab 2017;37:1148–62 doi:10.1177/0271678X16653133 pmid:27256323
    CrossRefPubMed
  8. 8.↵
    1. Ng F,
    2. Venkatraman V,
    3. Parsons M, et al
    . Gradient of tissue injury after stroke: rethinking the infarct versus noninfarcted dichotomy. Cerebrovasc Dis 2020;49:32–38 doi:10.1159/000505847 pmid:32069458
    CrossRefPubMed
  9. 9.↵
    1. Villringer K,
    2. Sanz Cuesta BE,
    3. Ostwaldt AC, et al
    . DCE-MRI blood-brain barrier assessment in acute ischemic stroke. Neurology 2017;88:433–40 doi:10.1212/WNL.0000000000003566 pmid:28031392
    Abstract/FREE Full Text
  10. 10.↵
    1. Amki ME,
    2. Wegener S
    . Reperfusion failure despite recanalization in stroke: new translational evidence. Clinical and Translational Neuroscience 2021;5:2514183X2110071 doi:10.1177/2514183X211007137
    CrossRef
  11. 11.↵
    1. Shaik NF,
    2. Regan RF,
    3. Naik UP
    . Platelets as drivers of ischemia/reperfusion injury after stroke. Blood Adv 2021;5:1576–84 doi:10.1182/bloodadvances.2020002888 pmid:33687431
    CrossRefPubMed
  12. 12.↵
    1. Kang L,
    2. Yu H,
    3. Yang X, et al
    . Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke. Nat Commun 2020;11:2488 doi:10.1038/s41467-020-16191-y pmid:32427863
    CrossRefPubMed
  13. 13.↵
    1. Erdener ŞE,
    2. Tang J,
    3. Kılıç K, et al
    . Dynamic capillary stalls in reperfused ischemic penumbra contribute to injury: a hyperacute role for neutrophils in persistent traffic jams. J Cereb Blood Flow Metab 2021;41:236–52 doi:10.1177/0271678X20914179 pmid:32237951
    CrossRefPubMed
  14. 14.↵
    1. Modrau B,
    2. Winder A,
    3. Hjort N, et al
    . Perfusion changes in acute stroke treated with theophylline as an add-on to thrombolysis: a randomized clinical trial subgroup analysis. Clin Neuroradiol 2022;32:345–52 doi:10.1007/s00062-021-01029-x pmid:34259904
    CrossRefPubMed
  15. 15.↵
    1. Tan IYL,
    2. Demchuk AM,
    3. Hopyan J, et al
    . CT angiography clot burden score and collateral score: correlation with clinical and radiologic outcomes in acute middle cerebral artery infarct. AJNR Am J Neuroradiol 2009;30:525–31 doi:10.3174/ajnr.A1408 pmid:19147716
    Abstract/FREE Full Text
  16. 16.↵
    1. Wu O,
    2. Østergaard L,
    3. Weisskoff RM, et al
    . Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix. Magn Reson Med 2003;50:164–74 doi:10.1002/mrm.10522 pmid:12815691
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Patlak CS,
    2. Blasberg RG,
    3. Fenstermacher JD
    . Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983;3:1–7 doi:10.1038/jcbfm.1983.1 pmid:6822610
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Jenkinson M,
    2. Smith S
    . A global optimisation method for robust affine registration of brain images. Med Image Anal 2001;5:143–56 doi:10.1016/s1361-8415(01)00036-6 pmid:11516708
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Jenkinson M,
    2. Bannister P,
    3. Brady M, et al
    . Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 2002;17:825–41 doi:10.1016/s1053-8119(02)91132-8 pmid:12377157
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Zhang Y,
    2. Brady M,
    3. Smith S
    . Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging 2001;20:45–57 doi:10.1109/42.906424 pmid:11293691
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Yushkevich PA,
    2. Piven J,
    3. Hazlett HC, et al
    . User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage 2006;31:1116–28 doi:10.1016/j.neuroimage.2006.01.015 pmid:16545965
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Ferguson GG,
    2. Eliasziw M,
    3. Barr HW, et al
    . The North American Symptomatic Carotid Endarterectomy Trial. Stroke 1999;30:1751–58 doi:10.1161/01.str.30.9.1751 pmid:10471419
    Abstract/FREE Full Text
  23. 23.↵
    1. Knox EG,
    2. Aburto MR,
    3. Clarke G, et al
    . The blood-brain barrier in aging and neurodegeneration. Mol Psychiatry 2022;27:2659–73 doi:10.1038/s41380-022-01511-z pmid:35361905
    CrossRefPubMed
  24. 24.↵
    1. Bai J,
    2. Lyden PD
    . Revisiting cerebral postischemic reperfusion injury: new insights in understanding reperfusion failure, hemorrhage, and edema. Int J Stroke 2015;10:143–52 doi:10.1111/ijs.12434 pmid:25598025
    CrossRefPubMed
  25. 25.↵
    1. Kidwell CS,
    2. Saver JL,
    3. Starkman S, et al
    . Diffusion-perfusion MRI characterization of post-recanalization hyperperfusion in humans. Neurology 2001;57:2015–21 doi:10.1212/wnl.57.11.2015 pmid:11739819
    Abstract/FREE Full Text
  26. 26.↵
    1. Arenillas JF,
    2. Cortijo E,
    3. García-Bermejo P, et al
    . Relative cerebral blood volume is associated with collateral status and infarct growth in stroke patients in SWIFT PRIME. J Cereb Blood Flow Metab 2018;38:1839–47 doi:10.1177/0271678X17740293 pmid:29135347
    CrossRefPubMed
  27. 27.↵
    1. Karonen JO,
    2. Partanen PL,
    3. Vanninen RL, et al
    . Evolution of MR contrast enhancement patterns during the first week after acute ischemic stroke. AJNR Am J Neuroradiol 2001;22:103–11
    Abstract/FREE Full Text
  28. 28.↵
    1. Nadareishvili Z,
    2. Simpkins AN,
    3. Hitomi E, et al
    . Post-stroke blood-brain barrier disruption and poor functional outcome in patients receiving thrombolytic therapy. Cerebrovasc Dis 2019;47:135–42 doi:10.1159/000499666 pmid:30970357
    CrossRefPubMed
  29. 29.↵
    1. Ng FC,
    2. Churilov L,
    3. Yassi N, et al
    ; EXTEND-IA TNK Part 1 and 2 Investigators. Reduced severity of tissue injury within the infarct may partially mediate the benefit of reperfusion in ischemic stroke. Stroke 2022;53:1915–23 doi:10.1161/STROKEAHA.121.036670 pmid:35135319
    CrossRefPubMed
  30. 30.↵
    1. Sarraj A,
    2. Hassan AE,
    3. Abraham MG, et al
    ; SELECT2 Investigators. Endovascular thrombectomy for large ischemic stroke across ischemic injury and penumbra profiles. JAMA 2024;331:750–63 doi:10.1001/jama.2024.0572 pmid:38324414
    CrossRefPubMed
  31. 31.↵
    1. Rosen BR,
    2. Belliveau JW,
    3. Vevea JM, et al
    . Perfusion imaging with NMR contrast agents. Magn Reson Med 1990;14:249–65 doi:10.1002/mrm.1910140211 pmid:2345506
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Cuenod CA,
    2. Balvay D
    . Perfusion and vascular permeability: basic concepts and measurement in DCE-CT and DCE-MRI. Diagn Interv Imaging 2013;94:1187–204 doi:10.1016/j.diii.2013.10.010 pmid:24211260
    CrossRefPubMed
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Cite this article
Matthias A. Mutke, Arne Potreck, Markus A. Möhlenbruch, Sabine Heiland, Sibu Mundiyanapurath, Mirko Pham, Martin Bendszus, Angelika Hoffmann
Hyperperfusion and Blood-Brain Barrier Disruption beyond the Diffusion-Restricted Infarct 1 Day after Successful Mechanical Thrombectomy
American Journal of Neuroradiology May 2025, 46 (5) 908-914; DOI: 10.3174/ajnr.A8602

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Hyperperfusion and Blood-Brain Barrier Disruption beyond the Diffusion-Restricted Infarct 1 Day after Successful Mechanical Thrombectomy
Matthias A. Mutke, Arne Potreck, Markus A. Möhlenbruch, Sabine Heiland, Sibu Mundiyanapurath, Mirko Pham, Martin Bendszus, Angelika Hoffmann
American Journal of Neuroradiology May 2025, 46 (5) 908-914; DOI: 10.3174/ajnr.A8602
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