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This meta-analysis evaluated randomized clinical trial results to provide more definitive guidance on the role of EVT for patients with stroke with large infarcts based on perfusion metrics. The results showed that the effectiveness of thrombectomy is uncertain regarding the safety and efficacy of thrombectomy for patients with limited areas of at-risk tissue. EVT may be beneficial for those with intermediate perfusion mismatch (ratio of 1.2-1.8 or volume of 10-15 mL) but not for those with low perfusion mismatch (ratio <1.2 or volume <10 mL).

This retrospective single-center cohort study investigated the discrepancy of 2 widely used postprocessing tools (Syngo.via and RapidAI) for CTP in patients with medium/distal vessel occlusion (MDVO) stroke. The 2 postprocessing tools were discordant on the volume and the location of perfusion deficit in isolated MDVO as well as the volume of potentially salvageable penumbra. As such, this questions whether infarct core size or penumbra volume should routinely be used to identify candidates for MDVO thrombectomy.