Risk of Hemorrhagic Transformation after Mechanical Thrombectomy without versus with IV Thrombolysis for Acute Ischemic Stroke: A Systematic Review and Meta-analysis of Randomized Clinical Trials

References

1. 1.↵
   1. Goyal M,
   2. Menon BK,
   3. Van Zwam WH, et al

   ; HERMES Collaborators. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet 2016;387:1723–31 doi:10.1016/S0140-6736(16)00163-X pmid:26898852

   CrossRefPubMed
2. 2.↵
   1. Ghaith HS,
   2. Elfil M,
   3. Gabra MD, et al

   . Intravenous thrombolysis before mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion; should we cross that bridge? A systematic review and meta-analysis of 36,123 patients. Neurol Sci 2022;43:6243–69 doi:10.1007/s10072-022-06283-6 pmid:35871179

   CrossRefPubMed
3. 3.↵
   1. Berge E,
   2. Whiteley W,
   3. Audebert H, et al

   . European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke. Eur Stroke J 2021;6:I–LXII doi:10.1177/2396987321989865 pmid:33817340

   CrossRefPubMed
4. 4.↵
   1. Hu X,
   2. Zhou Y,
   3. Ospel J, et al

   ; Direct-MT Investigators. Intracranial hemorrhage in large vessel occlusion patients receiving endovascular thrombectomy with or without intravenous alteplase: a secondary analysis of the DIRECT-MT trial. J Neurointerv Surg 2023;15:977–82 doi:10.1136/jnis-2022-019021 pmid:36270789

   Abstract/FREE Full Text
5. 5.↵
   1. Tong X,
   2. Wang Y,
   3. Fiehler J, et al

   ; ANGEL-ACT Study Group. Thrombectomy versus combined thrombolysis and thrombectomy in patients with acute stroke. Stroke 2021;52:1589–600 doi:10.1161/STROKEAHA.120.031599 pmid:33657849

   CrossRefPubMed
6. 6.↵
   1. Zheng M,
   2. Li L,
   3. Chen L, et al

   . Mechanical thrombectomy combined with intravenous thrombolysis for acute ischemic stroke: a systematic review and meta-analyses. Sci Rep 2023;13:8597 doi:10.1038/s41598-023-35532-7 pmid:37237159

   CrossRefPubMed
7. 7.↵
   1. Majoie CB,
   2. Cavalcante F,
   3. Gralla J, et al

   ; IRIS Collaborators. Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials. Lancet 2023;402:965–74 doi:10.1016/S0140-6736(23)01142-X pmid:37640037

   CrossRefPubMed
8. 8.↵
   1. Elfil M,
   2. Ghaith HS,
   3. Elsayed H, et al

   . Intravenous thrombolysis plus mechanical thrombectomy versus mechanical thrombectomy alone for acute ischemic stroke: a systematic review and updated meta-analysis of clinical trials. Interv Neuroradiol 202215910199221140276 doi:10.1177/15910199221140276 pmid:36437809

   CrossRefPubMed
9. 9.↵
   1. Higgins JP,
   2. Green S

   . Cochrane Handbook for Systematic Reviews of Interventions 5.1. 0. The Cochrane Collaboration; 2011
10. 10.↵
    1. Egger M,
    2. Smith GD,
    3. Schneider M, et al

    . Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629–34 doi:10.1136/bmj.315.7109.629 pmid:9310563

    Abstract/FREE Full Text
11. 11.↵
    1. Viechtbauer W,
    2. Cheung MW

    . Outlier and influence diagnostics for meta-analysis. Res Synth Methods 2010;1:112–25 doi:10.1002/jrsm.11 pmid:26061377

    CrossRefPubMed
12. 12.↵
    1. Coutinho JM,
    2. Liebeskind DS,
    3. Slater LA, et al

    . Combined intravenous thrombolysis and thrombectomy vs thrombectomy alone for acute ischemic stroke: a pooled analysis of the SWIFT and STAR Studies. JAMA Neurol 2017;74:268–74 doi:10.1001/jamaneurol.2016.5374 pmid:28097310

    CrossRefPubMed
13. 13.↵
    1. Fischer U,
    2. Kaesmacher J,
    3. Strbian D, et al

    ; SWIFT DIRECT Collaborators. Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial. Lancet 2022;400:104–15 doi:10.1016/S0140-6736(22)00537-2 pmid:35810756

    CrossRefPubMed
14. 14.↵
    1. Gariel F,
    2. Lapergue B,
    3. Bourcier R, et al

    ; ASTER Trial Investigators. Mechanical thrombectomy outcomes with or without intravenous thrombolysis insight from the ASTER randomized trial. Stroke 2018;49:2383–90 doi:10.1161/STROKEAHA.118.021500 pmid:30355117

    CrossRefPubMed
15. 15.↵
    1. LeCouffe NE,
    2. Kappelhof M,
    3. Treurniet KM, et al

    ; MR CLEAN–NO IV Investigators. A randomized trial of intravenous alteplase before endovascular treatment for stroke. N Engl J Med 2021;385:1833–44 doi:10.1056/NEJMoa2107727 pmid:34758251

    CrossRefPubMed
16. 16.↵
    1. Mitchell PJ,
    2. Yan B,
    3. Churilov L, et al

    ; DIRECT-SAFE Investigators. Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial. Lancet 2022;400:116–25 doi:10.1016/S0140-6736(22)00564-5 pmid:35810757

    CrossRefPubMed
17. 17.↵
    1. Suzuki K,
    2. Matsumaru Y,
    3. Takeuchi M, et al

    ; SKIP Study Investigators. Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: the SKIP Randomized Clinical Trial. JAMA 2021;325:244–53 doi:10.1001/jama.2020.23522 pmid:33464334

    CrossRefPubMed
18. 18.↵
    1. Yang P,
    2. Zhang Y,
    3. Zhang L

    et al; DIRECT-MT Investigators. Endovascular thrombectomy with or without intravenous alteplase in acute stroke. N Engl J Med 2020;382:1981–93 doi:10.1056/NEJMoa2001123 pmid:32374959

    CrossRefPubMed
19. 19.↵
    1. Zi W,
    2. Qiu Z,
    3. Li F, et al

    ; DEVT Trial Investigators. Effect of endovascular treatment alone vs intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke: the DEVT Randomized Clinical Trial. JAMA 2021;325:234–43 doi:10.1001/jama.2020.23523 pmid:33464335

    CrossRefPubMed
20. 20.↵
    1. Maxim M,
    2. Muhammad W,
    3. Johanna TF, et al

    . Intravenous alteplase has different effects on the efficacy of aspiration and stent retriever thrombectomy: analysis of the COMPASS trial. J Neurointerv Surg 2022;14:992–96 doi:10.1136/neurintsurg-2021-017943 pmid:34649935

    Abstract/FREE Full Text
21. 21.↵
    1. Du H,
    2. Lei H,
    3. Ambler G, et al

    . Intravenous thrombolysis before mechanical thrombectomy for acute ischemic stroke: a meta‐analysis. J Am Heart Assoc 2021;10:e022303 doi:10.1161/JAHA.121.022303 pmid:34779235

    CrossRefPubMed
22. 22.↵
    1. Desilles JP,
    2. Loyau S,
    3. Syvannarath V, et al

    . Alteplase reduces downstream microvascular thrombosis and improves the benefit of large artery recanalization in stroke. Stroke 2015;46:3241–48 doi:10.1161/STROKEAHA.115.010721 pmid:26443832

    Abstract/FREE Full Text
23. 23.↵
    1. Tsivgoulis G,
    2. Katsanos AH,
    3. Schellinger PD, et al

    . Successful reperfusion with intravenous thrombolysis preceding mechanical thrombectomy in large-vessel occlusions. Stroke 2018;49:232–35 doi:10.1161/STROKEAHA.117.019261 pmid:29212743

    Abstract/FREE Full Text
24. 24.↵
    1. Fredriksson L,
    2. Lawrence DA,
    3. Medcalf RL

    . tPA modulation of the blood-brain barrier: a unifying explanation for the pleiotropic effects of tPA in the CNS. Semin Thromb Hemost 2017;43:154–68 doi:10.1055/s-0036-1586229 pmid:27677179

    CrossRefPubMed
25. 25.↵
    1. Wardlaw JM,
    2. Murray V,
    3. Berge E, et al

    . Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev 2014;2014:CD000213 doi:10.1002/14651858.CD000213.pub3 pmid:25072528

    CrossRefPubMed
26. 26.↵
    1. Alves HC,
    2. Treurniet KM,
    3. Jansen IGH, et al

    . Thrombus migration paradox in patients with acute ischemic stroke. Stroke 2019;50:3156–63 doi:10.1161/STROKEAHA.119.026107 pmid:31597552

    CrossRefPubMed
27. 27.↵
    1. Kaesmacher J,
    2. Boeckh-Behrens T,
    3. Simon S, et al

    . Risk of thrombus fragmentation during endovascular stroke treatment. AJNR Am J Neuroradiol 2017;38:991–98 doi:10.3174/ajnr.A5105 pmid:28279987

    Abstract/FREE Full Text
28. 28.↵
    1. Elfil M,
    2. Ghozy S,
    3. Elmashad A, et al

    . Effect of intra-arterial thrombolysis following successful endovascular thrombectomy on functional outcomes in patients with large vessel occlusion acute ischemic stroke: a post-CHOICE meta-analysis. J Stroke Cerebrovasc Dis 2023;32:107194 doi:10.1016/j.jstrokecerebrovasdis.2023.107194 pmid:37216750

    CrossRefPubMed
29. 29.↵
    1. Qian J,
    2. Fan L,
    3. Zhang W, et al

    . A meta-analysis of collateral status and outcomes of mechanical thrombectomy. Acta Neurol Scand 2020;142:191–99 doi:10.1111/ane.13255 pmid:32342996

    CrossRefPubMed
30. 30.↵
    1. Derraz I,
    2. Moulin S,
    3. Gory B, et al

    ; ETIS Investigators. Endovascular thrombectomy outcomes with and without intravenous thrombolysis for large ischemic cores identified with CT or MRI. Radiology 2023;309:e230440 doi:10.1148/radiol.230440 pmid:37847131

    CrossRefPubMed
31. 31.↵
    1. Elfil M,
    2. Ghaith HS,
    3. Bayoumi A, et al

    . Impact of pre-treatment cerebral microbleeds on the outcomes of endovascular thrombectomy: a systematic review and meta-analysis. J Stroke Cerebrovasc Dis 2023;32:107324 doi:10.1016/j.jstrokecerebrovasdis.2023.107324 pmid:37660553

    CrossRefPubMed
32. 32.↵
    1. Bilgin C,
    2. Tolba H,
    3. Ghozy S, et al

    . Effects of intravenous thrombolysis on stent retriever and aspiration thrombectomy outcomes: a systematic review and meta-analysis of the randomized controlled trials. J Neurointerv Surg 2024;16:163–70 doi:10.1136/jnis-2023-020360 pmid:37258225

    Abstract/FREE Full Text
33. 33.↵
    1. Xie H,
    2. Chen Y,
    3. Ge W, et al

    . Does endovascular thrombectomy (ET) plus tirofiban benefit stroke patients: a systematic review and meta-analysis. J Stroke Cerebrovasc Dis 2024;33:107494 doi:10.1016/j.jstrokecerebrovasdis.2023.107494 pmid:38035642

    CrossRefPubMed
34. 34.↵
    1. Heck DV,
    2. Brown MD

    . Carotid stenting and intracranial thrombectomy for treatment of acute stroke due to tandem occlusions with aggressive antiplatelet therapy may be associated with a high incidence of intracranial hemorrhage. J Neurointerv Surg 2015;7:170–75 doi:10.1136/neurintsurg-2014-011224 pmid:25387730

    Abstract/FREE Full Text
35. 35.↵
    1. van der Steen W,
    2. van de Graaf RA,
    3. Chalos V, et al

    ; MR CLEAN-MED Investigators. Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial. Lancet 2022;399:1059–69 doi:10.1016/S0140-6736(22)00014-9 pmid:35240044

    CrossRefPubMed
36. 36.↵
    1. Hao Z,
    2. Yang C,
    3. Xiang L, et al

    . Risk factors for intracranial hemorrhage after mechanical thrombectomy: a systematic review and meta-analysis. Expert Rev Neurother 2019;19:927–35 doi:10.1080/14737175.2019.1632191 pmid:31200607

    CrossRefPubMed
37. 37.↵
    1. Tian B,
    2. Tian X,
    3. Shi Z, et al

    ; DIRECT-MT Investigators. Clinical and imaging indicators of hemorrhagic transformation in acute ischemic stroke after endovascular thrombectomy. Stroke 2022;53:1674–81 doi:10.1161/STROKEAHA.121.035425 pmid:34872341

    CrossRefPubMed