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Research ArticleMolecular Neuroimaging/Nuclear Medicine

DOTATATE PET/MR Imaging Differentiates Secondary-Progressive from de Novo World Health Organization Grade 3 Meningiomas

Joon Tae Kim, Se Jung Chris Chang, Arsalan Haghdel, Rohan R. Ramakrishna, Susan C. Pannullo, Theodore H. Schwartz, Joseph R. Osborne, Rajiv S. Magge, Howard A. Fine, Babacar Cisse, Philip Stieg, Eaton Lin, Michelle Roytman, Joshua D. Palmer, Nicolas A. Karakatsanis, David Pisapia, Benjamin Liechty, Jonathan P.S. Knisely and Jana Ivanidze
American Journal of Neuroradiology June 2024, 45 (6) 773-780; DOI: https://doi.org/10.3174/ajnr.A8219
Joon Tae Kim
aFrom the Weill Cornell Medical College (J.T.K., S.J.C.C., A.H.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Se Jung Chris Chang
aFrom the Weill Cornell Medical College (J.T.K., S.J.C.C., A.H.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Arsalan Haghdel
aFrom the Weill Cornell Medical College (J.T.K., S.J.C.C., A.H.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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  • ORCID record for Arsalan Haghdel
Rohan R. Ramakrishna
bDepartment of Neurological Surgery (R.R.R., S.C.P., T.H.S., B.C., P.S.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Susan C. Pannullo
bDepartment of Neurological Surgery (R.R.R., S.C.P., T.H.S., B.C., P.S.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Theodore H. Schwartz
bDepartment of Neurological Surgery (R.R.R., S.C.P., T.H.S., B.C., P.S.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Joseph R. Osborne
cDepartments of Radiology (J.R.O., E.L., M.R., N.A.K., J.I.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Rajiv S. Magge
dDepartment of Neurology (R.S.M., H.A.F.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Howard A. Fine
dDepartment of Neurology (R.S.M., H.A.F.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Babacar Cisse
bDepartment of Neurological Surgery (R.R.R., S.C.P., T.H.S., B.C., P.S.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Philip Stieg
bDepartment of Neurological Surgery (R.R.R., S.C.P., T.H.S., B.C., P.S.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Eaton Lin
cDepartments of Radiology (J.R.O., E.L., M.R., N.A.K., J.I.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Michelle Roytman
cDepartments of Radiology (J.R.O., E.L., M.R., N.A.K., J.I.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Joshua D. Palmer
eDepartment of Neuro-Oncology (J.D.P.), Ohio State University, Columbus, Ohio
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Nicolas A. Karakatsanis
cDepartments of Radiology (J.R.O., E.L., M.R., N.A.K., J.I.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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David Pisapia
fDepartment of Pathology and Laboratory Medicine (D.P., B.L.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Benjamin Liechty
fDepartment of Pathology and Laboratory Medicine (D.P., B.L.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Jonathan P.S. Knisely
gDepartment of Radiation Oncology (J.P.S.K.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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Jana Ivanidze
cDepartments of Radiology (J.R.O., E.L., M.R., N.A.K., J.I.), Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
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References

  1. 1.↵
    1. Ostrom QT,
    2. Gittleman H,
    3. Liao P, et al
    . CBTRUS Statistical Report: primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014. Neuro Oncol 2017;19:v1–88 doi:10.1093/neuonc/nox158 pmid:29117289
    CrossRefPubMed
  2. 2.↵
    1. Tian W,
    2. Liu J,
    3. Zhao K, et al
    . Analysis of prognostic factors of World Health Organization grade III meningiomas. Front Oncol 2020;10:593073 doi:10.3389/fonc.2020.593073 pmid:33425743
    CrossRefPubMed
  3. 3.↵
    1. Durand A,
    2. Labrousse F,
    3. Jouvet A, et al
    . WHO grade II and III meningiomas: a study of prognostic factors. J Neurooncol 2009;95:367–75 doi:10.1007/s11060-009-9934-0 pmid:19562258
    CrossRefPubMed
  4. 4.↵
    1. Masalha W,
    2. Heiland DH,
    3. Delev D, et al
    . Survival and prognostic predictors of anaplastic meningiomas. World Neurosurg 2019;131:e321–28 doi:10.1016/j.wneu.2019.07.148 pmid:31356972
    CrossRefPubMed
  5. 5.↵
    1. Harter PN,
    2. Braun Y,
    3. Plate KH
    . Classification of meningiomas-advances and controversies. Chin Clin Oncol 2017;6(Suppl 1):S2 doi:10.21037/cco.2017.05.02 pmid:28595423
    CrossRefPubMed
  6. 6.↵
    1. Kunz WG,
    2. Jungblut LM,
    3. Kazmierczak PM, et al
    . Improved detection of transosseous meningiomas using 68 Ga-DOTATATE PET/CT compared with contrast-enhanced MRI. J Nucl Med 2017;58:1580–87 doi:10.2967/jnumed.117.191932 pmid:28450556
    Abstract/FREE Full Text
  7. 7.↵
    1. Ivanidze J,
    2. Roytman M,
    3. Lin E, et al
    . Gallium-68 DOTATATE PET in the evaluation of intracranial meningiomas. J Neuroimaging 2019;29:650–56 doi:10.1111/jon.12632 pmid:31107591
    CrossRefPubMed
  8. 8.↵
    1. Mizutani G,
    2. Nakanishi Y,
    3. Watanabe N, et al
    . Expression of somatostatin receptor (SSTR) subtypes (SSTR-1, 2A, 3, 4 and 5) in neuroendocrine tumors using real-time RT-PCR method and immunohistochemistry. Acta Histochem Cytochem 2012;45:167–76 doi:10.1267/ahc.12006 pmid:22829710
    CrossRefPubMed
  9. 9.↵
    1. Huang RY,
    2. Bi WL,
    3. Weller M, et al
    . Proposed response assessment and endpoints for meningioma clinical trials: report from the Response Assessment in Neuro-Oncology Working Group. Neuro Oncol 2019;21:26–36 doi:10.1093/neuonc/noy137 pmid:30137421
    CrossRefPubMed
  10. 10.↵
    1. Kim SH,
    2. Roytman M,
    3. Madera G, et al
    . Evaluating diagnostic accuracy and determining optimal diagnostic thresholds of different approaches to [68Ga]-DOTATATE PET/MRI analysis in patients with meningioma. Sci Rep 2022;12:9256 doi:10.1038/s41598-022-13467-9 pmid:35661809
    CrossRefPubMed
  11. 11.↵
    1. Hoffman S,
    2. Propp JM,
    3. McCarthy BJ
    . Temporal trends in incidence of primary brain tumors in the United States, 1985-1999. Neuro Oncol 2006;8:27–37 doi:10.1215/S1522851705000323 pmid:16443945
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Okano A,
    2. Miyawaki S,
    3. Teranishi Y, et al
    . Advances in molecular biological and translational studies in World Health Organization grades 2 and 3 meningiomas: a literature review. Neurol Med Chir (Tokyo) 2022;62:347–60 doi:10.2176/jns-nmc.2022-0114
    CrossRefPubMed
  13. 13.↵
    1. Zhang P,
    2. Yu J,
    3. Li J, et al
    . Clinical and prognostic value of PET/CT imaging with combination of 68 Ga-DOTATATE and 18 F-FDG in gastroenteropancreatic neuroendocrine neoplasms. Contrast Media Mol Imaging 2018;2018:2340389 doi:10.1155/2018/2340389 pmid:29681780
    CrossRefPubMed
  14. 14.↵
    1. Günther T,
    2. Tulipano G,
    3. Dournaud P, et al
    . International union of basic and clinical pharmacology. CV. Somatostatin receptors: structure, function, ligands, and new nomenclature. Pharmacol Rev 2018;70:763–835 doi:10.1124/pr.117.015388 pmid:30232095
    Abstract/FREE Full Text
  15. 15.↵
    1. Vasilaki A,
    2. Thermos K
    . Somatostatin analogues as therapeutics in retinal disease. Pharmacol Ther 2009;122:324–33 doi:10.1016/j.pharmthera.2009.03.010 pmid:19351548
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Bassant MH,
    2. Simon A,
    3. Poindessous-Jazat F, et al
    . Medial septal GABAergic neurons express the somatostatin sst2A receptor: functional consequences on unit firing and hippocampal theta. J Neurosci 2005;25:2032–41 doi:10.1523/JNEUROSCI.4619-04.2005 pmid:15728843
    Abstract/FREE Full Text
  17. 17.↵
    1. Barresi V,
    2. Alafaci C,
    3. Salpietro F, et al
    . Sstr2A immunohistochemical expression in human meningiomas: is there a correlation with the histological grade, proliferation or microvessel density? Oncol Rep 2008;20:485–92 pmid:18695896
    PubMedWeb of Science
  18. 18.↵
    1. de Oliveira Silva CB,
    2. Ongaratti BR,
    3. Trott G, et al
    . Expression of somatostatin receptors (SSTR1-SSTR5) in meningiomas and its clinicopathological significance. Int J Clin Exp Pathol 2015;8:13185–92 pmid:26722517
    PubMed
  19. 19.↵
    1. Seystahl K,
    2. Stoecklein V,
    3. Schüller U, et al
    . Somatostatin receptor-targeted radionuclide therapy for progressive meningioma: benefit linked to 68Ga-DOTATATE/-TOC uptake. Neuro Oncol 2016;18:1538–47 doi:10.1093/neuonc/now060 pmid:27106404
    CrossRefPubMed
  20. 20.↵
    1. Sommerauer M,
    2. Burkhardt JK,
    3. Frontzek K, et al
    . 68 Gallium-DOTATATE PET in meningioma: a reliable predictor of tumor growth rate? Neuro Oncol 2016;18:1021–27 doi:10.1093/neuonc/now001 pmid:26865086
    CrossRefPubMed
  21. 21.↵
    1. Roytman M,
    2. Kim S,
    3. Glynn S, et al
    . PET/MR imaging of somatostatin receptor expression and tumor vascularity in meningioma: implications for pathophysiology and tumor outcomes. Front Oncol 2021;11:820287 doi:10.3389/fonc.2021.820287 pmid:35155210
    CrossRefPubMed
  22. 22.↵
    1. Laudicella R,
    2. Albano D,
    3. Annunziata S, et al
    . Theragnostic use of radiolabelled dota-peptides in meningioma: from clinical demand to future applications. Cancers (Basel) 2019;11:1412 doi:10.3390/cancers11101412 pmid:31546734
    CrossRefPubMed
  23. 23.↵
    1. Van Essen M,
    2. Kenning EP,
    3. Kooij PP, et al
    . Effects of therapy with [177 Lu-DOTA 0, Tyr 3] octreotate in patients with paraganglioma, meningioma, small cell lung carcinoma, and melanoma. J Nucl Med 2006;47:1599–606 pmid:17015894
    Abstract/FREE Full Text
  24. 24.↵
    1. Moazzam AA,
    2. Wagle N,
    3. Zada G
    . Recent developments in chemotherapy for meningiomas: a review. Neurosurg Focus 2013;35:E18 doi:10.3171/2013.10.FOCUS13341 pmid:24289126
    CrossRefPubMed
  25. 25.↵
    1. Roytman M,
    2. Pisapia DJ,
    3. Liechty B, et al
    . Somatostatin receptor-2 negative meningioma: pathologic correlation and imaging implications. Clin Imaging 2020;66:18–22 doi:10.1016/j.clinimag.2020.04.026 pmid:32442855
    CrossRefPubMed
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Cite this article
Joon Tae Kim, Se Jung Chris Chang, Arsalan Haghdel, Rohan R. Ramakrishna, Susan C. Pannullo, Theodore H. Schwartz, Joseph R. Osborne, Rajiv S. Magge, Howard A. Fine, Babacar Cisse, Philip Stieg, Eaton Lin, Michelle Roytman, Joshua D. Palmer, Nicolas A. Karakatsanis, David Pisapia, Benjamin Liechty, Jonathan P.S. Knisely, Jana Ivanidze
DOTATATE PET/MR Imaging Differentiates Secondary-Progressive from de Novo World Health Organization Grade 3 Meningiomas
American Journal of Neuroradiology Jun 2024, 45 (6) 773-780; DOI: 10.3174/ajnr.A8219

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DOTATATE PET/MR Distinguishes Meningioma Types
Joon Tae Kim, Se Jung Chris Chang, Arsalan Haghdel, Rohan R. Ramakrishna, Susan C. Pannullo, Theodore H. Schwartz, Joseph R. Osborne, Rajiv S. Magge, Howard A. Fine, Babacar Cisse, Philip Stieg, Eaton Lin, Michelle Roytman, Joshua D. Palmer, Nicolas A. Karakatsanis, David Pisapia, Benjamin Liechty, Jonathan P.S. Knisely, Jana Ivanidze
American Journal of Neuroradiology Jun 2024, 45 (6) 773-780; DOI: 10.3174/ajnr.A8219
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