A Comprehensive and Broad Approach to Resting-State Functional Connectivity in Adult Patients with Mild Traumatic Brain Injury

ROI-to-voxel results showing voxels with based on any effect F-test statistics. All 32 ROIs from the standard functional parcellation of CONN are included here to highlight possible areas of connectivity difference between mTBI and control groups. The highlighted voxels are seen to be scattered across the brain, and no cluster survives after FDR and TFCE correction.

Similar to ROI-to-voxel analysis, this figure illustrates voxels with according to any effect F-test on all 20 spatial-GICs. As in the analysis in Fig 2, no regions survive FDR and TFCE.

Temporal-GICs analysis results. A and B, The connectivity matrix for control and mTBI groups. The color for each pair of temporal-GICs reflects statistically significant connectivity after FDR correction ( measured by average Fisher z-transformation of the Pearson correlation coefficient. C, Matrix of significant connections, comparing A and B: Red indicates significant connections unique to the mTBI group; blue indicates significant connections unique to the control group; and green indicates significance in both the mTBI and control groups. D, Matrix of mean difference (mTBI and controls) for the temporal-GICs connections that satisfy using the Welch t test comparing those with mTBI with controls. Highlighted connections involve temporal-GICs of 6 IFCNs, excepting sensorimotor, frontoparietal, and dorsal attention; however, the magnitude of differences is small. E, After multiple comparison correction (FDR) to account for the number of connections examined, no difference remains significant. IC indicates independent component.