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Research ArticlePediatrics
Open Access

Epileptogenic Tubers Are Associated with Increased Kurtosis of Susceptibility Values: A Combined Quantitative Susceptibility Mapping and Stereoelectroencephalography Pilot Study

A. Chari, J. Sedlacik, K. Seunarine, R.J. Piper, P. Hales, K. Shmueli, K. Mankad, U. Löbel, C. Eltze, F. Moeller, R.C. Scott, M.M. Tisdall, J.H. Cross and D.W. Carmichael
American Journal of Neuroradiology August 2023, 44 (8) 974-982; DOI: https://doi.org/10.3174/ajnr.A7929
A. Chari
aFrom Developmental Neurosciences (A.C., K. Seunarine, R.J.P., M.M.T., J.H.C.), Great Ormond Street Institute of Child Health
cDepartments of Neurosurgery (A.C., K. Seunarine, R.J.P. M.M.T.)
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J. Sedlacik
dNeuroradiology (J.S., P.H., K.M., U.L.)
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K. Seunarine
aFrom Developmental Neurosciences (A.C., K. Seunarine, R.J.P., M.M.T., J.H.C.), Great Ormond Street Institute of Child Health
cDepartments of Neurosurgery (A.C., K. Seunarine, R.J.P. M.M.T.)
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R.J. Piper
aFrom Developmental Neurosciences (A.C., K. Seunarine, R.J.P., M.M.T., J.H.C.), Great Ormond Street Institute of Child Health
cDepartments of Neurosurgery (A.C., K. Seunarine, R.J.P. M.M.T.)
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P. Hales
dNeuroradiology (J.S., P.H., K.M., U.L.)
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K. Shmueli
bDepartment of Medical Physics and Bioengineering (K. Shmueli), University College London, London, UK
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K. Mankad
dNeuroradiology (J.S., P.H., K.M., U.L.)
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U. Löbel
dNeuroradiology (J.S., P.H., K.M., U.L.)
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C. Eltze
eNeurology (C.E., R.C.S., J.H.C.)
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F. Moeller
fNeurophysiology (F.M.), Great Ormond Street Hospital, London, UK
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R.C. Scott
eNeurology (C.E., R.C.S., J.H.C.)
gDepartment of Pediatric Neurology (R.C.S.), Nemours Children’s Hospital, Wilmington, Delaware
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M.M. Tisdall
aFrom Developmental Neurosciences (A.C., K. Seunarine, R.J.P., M.M.T., J.H.C.), Great Ormond Street Institute of Child Health
cDepartments of Neurosurgery (A.C., K. Seunarine, R.J.P. M.M.T.)
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J.H. Cross
aFrom Developmental Neurosciences (A.C., K. Seunarine, R.J.P., M.M.T., J.H.C.), Great Ormond Street Institute of Child Health
eNeurology (C.E., R.C.S., J.H.C.)
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D.W. Carmichael
hEngineering and Physical Sciences Research Council/Wellcome Centre for Medical Engineering and Department of Biomedical Engineering (D.W.C.), School of Biomedical Engineering and Imaging Sciences, King’s College London, London, UK
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Article Information

vol. 44 no. 8 974-982
DOI 
https://doi.org/10.3174/ajnr.A7929
PubMed 
37474265

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received December 11, 2022
  • Accepted after revision June 7, 2023
  • Published online August 9, 2023.

Article Versions

  • Latest version (July 20, 2023 - 06:43).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2023 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. A. Charia,c,
  2. J. Sedlacikd,
  3. K. Seunarinea,c,
  4. R.J. Pipera,c,
  5. P. Halesd,
  6. K. Shmuelib,
  7. K. Mankadd,
  8. U. Löbeld,
  9. C. Eltzee,
  10. F. Moellerf,
  11. R.C. Scotte,g,
  12. M.M. Tisdalla,c,
  13. J.H. Crossa,e and
  14. D.W. Carmichaelh
  1. aFrom Developmental Neurosciences (A.C., K. Seunarine, R.J.P., M.M.T., J.H.C.), Great Ormond Street Institute of Child Health
  2. bDepartment of Medical Physics and Bioengineering (K. Shmueli), University College London, London, UK
  3. cDepartments of Neurosurgery (A.C., K. Seunarine, R.J.P. M.M.T.)
  4. dNeuroradiology (J.S., P.H., K.M., U.L.)
  5. eNeurology (C.E., R.C.S., J.H.C.)
  6. fNeurophysiology (F.M.), Great Ormond Street Hospital, London, UK
  7. gDepartment of Pediatric Neurology (R.C.S.), Nemours Children’s Hospital, Wilmington, Delaware
  8. hEngineering and Physical Sciences Research Council/Wellcome Centre for Medical Engineering and Department of Biomedical Engineering (D.W.C.), School of Biomedical Engineering and Imaging Sciences, King’s College London, London, UK
  1. Please address correspondence to Aswin Chari, MD, Developmental Neurosciences, Great Ormond Street Institute of Child Health, University College London, 30 Guilford St, London, WC1N 1EH UK; e-mail: Aswin.chari.18{at}ucl.ac.uk; @aswinchari
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Funding

  • National Institute of Health

  • Great Ormond Street Hospital (GOSH)

  • Research Biomedical Research Centre

  • GOSH

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  • Predictive model for epileptogenic tubers from all tubers in patients with tuberous sclerosis complex based on 18F-FDG PET: an 8-year single-centre study
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    BMC Medicine 2023 21 1
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Cite this article
A. Chari, J. Sedlacik, K. Seunarine, R.J. Piper, P. Hales, K. Shmueli, K. Mankad, U. Löbel, C. Eltze, F. Moeller, R.C. Scott, M.M. Tisdall, J.H. Cross, D.W. Carmichael
Epileptogenic Tubers Are Associated with Increased Kurtosis of Susceptibility Values: A Combined Quantitative Susceptibility Mapping and Stereoelectroencephalography Pilot Study
American Journal of Neuroradiology Aug 2023, 44 (8) 974-982; DOI: 10.3174/ajnr.A7929

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Kurtosis and Epileptogenic Tubers: A Pilot Study
A. Chari, J. Sedlacik, K. Seunarine, R.J. Piper, P. Hales, K. Shmueli, K. Mankad, U. Löbel, C. Eltze, F. Moeller, R.C. Scott, M.M. Tisdall, J.H. Cross, D.W. Carmichael
American Journal of Neuroradiology Aug 2023, 44 (8) 974-982; DOI: 10.3174/ajnr.A7929
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Predictive model for epileptogenic tubers from all tubers in patients with tuberous sclerosis complex based on 18F-FDG PET: an 8-year single-centre study
    Zhongke Wang, Yang Li, Zeng He, Shujing Li, Kaixuan Huang, Xianjun Shi, Xiaoqin Sun, Ruotong Ruan, Chun Cui, Ruodan Wang, Li Wang, Shengqing Lv, Chunqing Zhang, Zhonghong Liu, Hui Yang, Xiaolin Yang, Shiyong Liu
    BMC Medicine 2023 21 1

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