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Research ArticlePediatric Neuroimaging
Open Access

Doppler Ultrasound Flow Reversal in the Superior Sagittal Sinus to Detect Cerebral Venous Congestion in Vein of Galen Malformation

S. Schwarz, F. Brevis Nuñez, N.R. Dürr, F. Brassel, M. Schlunz-Hendann, A. Feldkamp, T. Rosenbaum, U. Felderhoff-Müser, K. Schulz, C. Dohna-Schwake and N. Bruns
American Journal of Neuroradiology June 2023, 44 (6) 707-715; DOI: https://doi.org/10.3174/ajnr.A7891
S. Schwarz
aFrom the Clinic for Pediatrics and Adolescent Medicine (S.S., F.B.N., A.F., T.R.)
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F. Brevis Nuñez
aFrom the Clinic for Pediatrics and Adolescent Medicine (S.S., F.B.N., A.F., T.R.)
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  • ORCID record for F. Brevis Nuñez
N.R. Dürr
bClinic for Radiology and Neuroradiology (N.R.D., F.B., M.S.-H., K.S.)
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F. Brassel
bClinic for Radiology and Neuroradiology (N.R.D., F.B., M.S.-H., K.S.)
cCenter for Pediatric Interventional Radiology/Neuroradiology and Interventional Treatment of Vascular Malformations (F.B.), Sana Clinics Duisburg, Duisburg, Germany
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M. Schlunz-Hendann
bClinic for Radiology and Neuroradiology (N.R.D., F.B., M.S.-H., K.S.)
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  • ORCID record for M. Schlunz-Hendann
A. Feldkamp
aFrom the Clinic for Pediatrics and Adolescent Medicine (S.S., F.B.N., A.F., T.R.)
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T. Rosenbaum
aFrom the Clinic for Pediatrics and Adolescent Medicine (S.S., F.B.N., A.F., T.R.)
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U. Felderhoff-Müser
dClinic for Pediatrics I (U.F.-M., C.D.-S., N.B.)
eCentre for Translational Neuro- and Behavioural Sciences (U.F.-M., C.D.-S., N.B.), University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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K. Schulz
bClinic for Radiology and Neuroradiology (N.R.D., F.B., M.S.-H., K.S.)
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C. Dohna-Schwake
dClinic for Pediatrics I (U.F.-M., C.D.-S., N.B.)
eCentre for Translational Neuro- and Behavioural Sciences (U.F.-M., C.D.-S., N.B.), University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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N. Bruns
dClinic for Pediatrics I (U.F.-M., C.D.-S., N.B.)
eCentre for Translational Neuro- and Behavioural Sciences (U.F.-M., C.D.-S., N.B.), University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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Figures

  • FIG 1.
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    FIG 1.

    Doppler imaging protocol of the SSS and cortical veins in a median sagittal section. A, SSS in median sagittal section in color-coded Doppler US with tilted Doppler beam (dotted line) and corresponding angular correction (white line). B, Cortical arteries and veins in sagittal section in color-coded Doppler US show possible measurement points (white lines).

  • FIG 2.
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    FIG 2.

    Classification of Doppler FPs of the SSS in neonates with vein of Galen malformation. A, FP1: Doppler FP with low fluctuation, minimum velocity, never less than half of the maximum velocity. B, FP2: Increased fluctuations of the flow velocities with minimum velocity less than half of the maximum velocity. C, FP3: Doppler FP with intermittent retrograde flow. D, FP4: Doppler FP with pulsatile retrograde flow. E, FP5: Doppler FP with a high retrograde flow (equal or more than one-third retrograde flow of the total Doppler flow). F, FP6: Doppler FP with complete retrograde flow.

  • FIG 3.
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    FIG 3.

    Scheme and MR imaging of a VGAM. A, Simplified scheme of VGAM. B, Sagittal T2-weighted MR image. C, Arterial TOF-MRA. D, Venous TOF-MRA. 1) internal carotid artery; 2) basilar artery; 3) anterior cerebral artery; 4) pericallosal artery; 5) posterior cerebral artery; 6) dilated MPV; 7) falcine sinus; 8) straight sinus; 9) accessory confluence; 10) SSS; 11) transverse sinus; 12) internal jugular vein.

  • FIG 4.
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    FIG 4.

    A, Individual course of the FPs in the SSS across time per patient. T1 = US Doppler measurement before embolization/first cMRI; T2 = US Doppler measurement 1 day after embolization/first cMRI; T3 = US Doppler measurement 5–7 days after embolization; T4 = US Doppler measurement before discharge. B, Association between Doppler FPs and BNES before therapy. Spearman rank correlation coefficient ρ = −0.97 (95% CI, −0.995 to −0.787; P < . 0001). Pat. indicates patient.

  • FIG 5.
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    FIG 5.

    Relationship between the FP in the SSS at T1 and T4 and the damage due to venous congestion detectable in the first and second cMRI.

  • FIG 6.
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    FIG 6.

    A, Timeline of the FPs in the SSS during 9 life months in patient 5. B, Course of Doppler FPs in the SSS under endovascular interventional therapy of stenosis of the jugular bulb in patient 5 (in the angiography room at the age of 16 weeks). A (upper left), An US Doppler FP in the SSS directly before balloon dilation on the left showing an arterialized retrograde flow. B (upper right), After balloon dilation and stent implantation on the left side decrease in flow velocities with reduced retrograde flow. C (bottom left), After additional balloon dilation on the right side, further reduction of the retrograde flow component and normalization of the flow direction. D (bottom right), At 24 hours after the procedure, further normalization of the US Doppler FP and increased undulation with minor retrograde components. Vmax indicates maximum velocity; Vmin, minimum velocity.

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American Journal of Neuroradiology: 44 (6)
American Journal of Neuroradiology
Vol. 44, Issue 6
1 Jun 2023
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S. Schwarz, F. Brevis Nuñez, N.R. Dürr, F. Brassel, M. Schlunz-Hendann, A. Feldkamp, T. Rosenbaum, U. Felderhoff-Müser, K. Schulz, C. Dohna-Schwake, N. Bruns
Doppler Ultrasound Flow Reversal in the Superior Sagittal Sinus to Detect Cerebral Venous Congestion in Vein of Galen Malformation
American Journal of Neuroradiology Jun 2023, 44 (6) 707-715; DOI: 10.3174/ajnr.A7891

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Doppler US for Cerebral Venous Congestion
S. Schwarz, F. Brevis Nuñez, N.R. Dürr, F. Brassel, M. Schlunz-Hendann, A. Feldkamp, T. Rosenbaum, U. Felderhoff-Müser, K. Schulz, C. Dohna-Schwake, N. Bruns
American Journal of Neuroradiology Jun 2023, 44 (6) 707-715; DOI: 10.3174/ajnr.A7891
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