Article Figures & Data
Figures
- FIG 1.
Study flow chart for SOLSTICE. The asterisk indicates that 5 patients did not have 90-day follow-up data.
- FIG 2.
mRS distribution at 90 days in patients with M1 and M2 occlusion in this study versus patients with M2 occlusion treated with endovascular thrombectomy in the HERMES collaboration.
Tables
- Table 1:
Patient baseline characteristics and outcomes stratified by MCA occlusion locationa
Characteristic M2 Occlusion (n = 94) M1 Occlusion (n = 367) Missing Age (median) (IQR) (yr)b 75 (63–82) 69 (58–78) 0 Female sex 51 (54.3) 193 (52.6) 0 Stroke presentation Wake-up stroke 49/93 (52.7) 187/349 (53.6) 19 Baseline NIHSS (median) (IQR)b 10 (7–15) 16 (11–20) 1 Tandem cervical occlusion 10 (10.6) 46 (12.5) 0 IV Alteplase 12 (12.8) 34 (9.3) 0 Time metrics (median) (IQR) (min) Time from onset to ED door 545 (368–730), [n = 91] 538 (405–692), [n = 342] 28 Time from onset to CT scan 579 (416–735), [n = 91] 551 (430–710), [n = 359] 11 Time from onset to puncture 744 (485–900), [n = 87] 631 (521–815), [n = 348] 26 Time from onset to reperfusion 762 (530–968), [n = 85] 671 (570–848), [n = 333] 26 Time from puncture to reperfusionb 45 (26–64), [n = 85] 30 (19–50), [n = 333] 25 Imaging factors ASPECTSb 9 (8–10) 8 (7–9) 2 Use of perfusion imaging 67 (71.3) 223 (60.7) 0 Outcomes Final TICI 2b–3 78 (82.9) 297 (81.1) 1 Final TICI 2c–3 29 (30.8) 119 (32.4) 1 SICHb 4/92 (4.3) 41/337 (12.2) 32 90-Day mRS (median) IQR) 2 (1–3) [n = 89] 3 (1–5) [n = 349] 23 90-Day mRS = 0–1 36/89 (40.4) 102/349 (29.2) 23 90-Day mRS = 0–2b 53/89 (59.6) 157/349 (45.0) 23 90-Day mortality 10/89 (11.2) 60/349 (17.2) 23 - Table 2:
Primary and secondary outcomes in patients with M2 occlusion stratified by successful reperfusiona
Successful Reperfusion (n = 75) Unsuccessful Reperfusion (n = 14) P Value Unadjusted OR (95% CI) Adjusted OR (95% CI) 90-Day mRS 0–2 48 (64.0) 5 (35.7) .07 3.20 (0.97–10.52) 2.84 (1.11–7.29)b 90-Day mRS 0–1 33 (44.0) 3 (21.4) .14 2.88 (0.74–11.17) 2.52 (0.82–7.67) 90-Day mortality 8 (10.7) 2 (14.3) .65 0.72 (0.13–3.79) 0.13 (0.02–0.67)b SICH 4 (5.3) 0 (0.0) .99 – – Note:—En dash indicates that logistic regression was not performed because of the low number of events (n < 10).
↵a Data on 90-day mRS was missing for 5 patients. Regression analyses were not performed for SICH because the number of events was zero in the unsuccessful reperfusion group. Successful reperfusion was defined as a final eTICI 2b–3. The numbers in parentheses in columns 2 and 3 indicate percentages.
↵b Significant results.
- Table 3:
Comparison of clinical outcomes in patients with M2 occlusions treated with endovascular thrombectomy in the current study versus the HERMES collaboration studya
Current Study (n = 94) HERMES (n = 67) Final TICI 2b–3 82.9% (78/94) 59.2% (40/67) SICH 4.3% (4/92) 0.0% (0/67) 90-Day mRS = 0–1 40.4% (36/89) 37.3% (25/67) 90-Day mRS = 0–2 59.6% (53/89) 58.2% (39/67) 90-Day mortality 11.2% (10/89) 11.9% (8/67) ↵a Data are percentages (n/N).
