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Review ArticleNeurointervention
Open Access

Flow Diversion in the Treatment of Intracranial Aneurysms: A Pragmatic Randomized Care Trial

J. Raymond, D. Iancu, W. Boisseau, J.D.B. Diestro, R. Klink, M. Chagnon, J. Zehr, B. Drake, H. Lesiuk, A. Weill, D. Roy, M.W. Bojanowski, C. Chaalala, J.L. Rempel, C. O’Kelly, M.M. Chow, S. Bracard and T.E. Darsaut
American Journal of Neuroradiology September 2022, 43 (9) 1244-1251; DOI: https://doi.org/10.3174/ajnr.A7597
J. Raymond
aFrom the Department of Radiology (J.R., D.I., W.B., J.D.B.D., R.K., A.W., D.R.), Centre Hospitalier de l’Université de Montréal, Quebec, Canada
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  • ORCID record for J. Raymond
D. Iancu
aFrom the Department of Radiology (J.R., D.I., W.B., J.D.B.D., R.K., A.W., D.R.), Centre Hospitalier de l’Université de Montréal, Quebec, Canada
bDepartments of Radiology (D.I.)
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W. Boisseau
aFrom the Department of Radiology (J.R., D.I., W.B., J.D.B.D., R.K., A.W., D.R.), Centre Hospitalier de l’Université de Montréal, Quebec, Canada
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J.D.B. Diestro
aFrom the Department of Radiology (J.R., D.I., W.B., J.D.B.D., R.K., A.W., D.R.), Centre Hospitalier de l’Université de Montréal, Quebec, Canada
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R. Klink
aFrom the Department of Radiology (J.R., D.I., W.B., J.D.B.D., R.K., A.W., D.R.), Centre Hospitalier de l’Université de Montréal, Quebec, Canada
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M. Chagnon
dDepartment of Mathematics and Statistics (M.C., J.Z.), Université de Montréal, Montreal, Canada
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J. Zehr
dDepartment of Mathematics and Statistics (M.C., J.Z.), Université de Montréal, Montreal, Canada
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B. Drake
cSurgery (B.D., H.L.), Ottawa Hospital, Civic Campus, Ottawa, Ontario, Canada
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H. Lesiuk
cSurgery (B.D., H.L.), Ottawa Hospital, Civic Campus, Ottawa, Ontario, Canada
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A. Weill
aFrom the Department of Radiology (J.R., D.I., W.B., J.D.B.D., R.K., A.W., D.R.), Centre Hospitalier de l’Université de Montréal, Quebec, Canada
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D. Roy
aFrom the Department of Radiology (J.R., D.I., W.B., J.D.B.D., R.K., A.W., D.R.), Centre Hospitalier de l’Université de Montréal, Quebec, Canada
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M.W. Bojanowski
eDepartment of Neurosurgery (M.W.B., C.C.), Centre Hospitalier de l’Université de Montréal, Notre-Dame Hospital, Montreal, Quebec, Canada
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C. Chaalala
eDepartment of Neurosurgery (M.W.B., C.C.), Centre Hospitalier de l’Université de Montréal, Notre-Dame Hospital, Montreal, Quebec, Canada
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J.L. Rempel
fDepartments of Radiology (J.L.R.)
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C. O’Kelly
gSurgery (C.O., M.M.C., T.E.D.), Division of Neurosurgery, University of Alberta Hospital, Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada
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M.M. Chow
gSurgery (C.O., M.M.C., T.E.D.), Division of Neurosurgery, University of Alberta Hospital, Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada
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S. Bracard
hNeuroradiology (S.B.), CHRU de Nancy, Nancy, Lorraine, France
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T.E. Darsaut
gSurgery (C.O., M.M.C., T.E.D.), Division of Neurosurgery, University of Alberta Hospital, Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada
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Article Information

vol. 43 no. 9 1244-1251
DOI 
https://doi.org/10.3174/ajnr.A7597
PubMed 
35926886

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received May 30, 2022
  • Accepted after revision June 28, 2022
  • Published online September 7, 2022.

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  • Latest version (August 4, 2022 - 06:13).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2022 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. J. Raymonda,
  2. D. Iancua,b,
  3. W. Boisseaua,
  4. J.D.B. Diestroa,
  5. R. Klinka,
  6. M. Chagnond,
  7. J. Zehrd,
  8. B. Drakec,
  9. H. Lesiukc,
  10. A. Weilla,
  11. D. Roya,
  12. M.W. Bojanowskie,
  13. C. Chaalalae,
  14. J.L. Rempelf,
  15. C. O’Kellyg,
  16. M.M. Chowg,
  17. S. Bracardh and
  18. T.E. Darsautg
  1. aFrom the Department of Radiology (J.R., D.I., W.B., J.D.B.D., R.K., A.W., D.R.), Centre Hospitalier de l’Université de Montréal, Quebec, Canada
  2. bDepartments of Radiology (D.I.)
  3. cSurgery (B.D., H.L.), Ottawa Hospital, Civic Campus, Ottawa, Ontario, Canada
  4. dDepartment of Mathematics and Statistics (M.C., J.Z.), Université de Montréal, Montreal, Canada
  5. eDepartment of Neurosurgery (M.W.B., C.C.), Centre Hospitalier de l’Université de Montréal, Notre-Dame Hospital, Montreal, Quebec, Canada
  6. fDepartments of Radiology (J.L.R.)
  7. gSurgery (C.O., M.M.C., T.E.D.), Division of Neurosurgery, University of Alberta Hospital, Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada
  8. hNeuroradiology (S.B.), CHRU de Nancy, Nancy, Lorraine, France
  1. Please address correspondence to Jean Raymond, MD, Centre Hospitalier de l’Université de Montréal (CHUM), Department of Radiology, Room D03.5462b, Montreal, PQ, Canada H2X 0C1; e-mail: jean.raymond{at}umontreal.ca; @RaymondJeanMD1
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    Journal of NeuroInterventional Surgery 2024 16 5
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  • Endovascular Parent Vessel Occlusion Versus Flow Diversion in the Treatment of Large and Giant Aneurysms: A Randomized Comparison
    William Boisseau, Tim E. Darsaut, Robert Fahed, Pierre Olivier Comby, Brian Drake, Howard Lesiuk, Jeremy L. Rempel, Cian J. O'Kelly, Michael M.C. Chow, Daniela E. Iancu, Daniel Roy, Alain Weill, Ruby Klink, Jean Raymond
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  • Optimizing Photon-Counting Detector CT for Imaging Intracranial Aneurysms
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    Neurochirurgie 2024 70 4
  • Understanding crossovers and potential ways to mitigate the problem: Lessons from influential trials on lumbar microdiscectomy
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    Neurochirurgie 2023 69 5
  • Understanding heterogeneity of pragmatic trial results and subgroup analyses: The FIAT example
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    Neurochirurgie 2025 71 4
  • In Reply to the Letter to the Editor Regarding: “Endovascular Parent Vessel Occlusion Versus Flow Diversion in the Treatment of Large and Giant Aneurysms: A Randomized Comparison”
    William Boisseau, Tim E. Darsaut, Jean Raymond
    World Neurosurgery 2024 187
  • Modeling Fibrin Accumulation on Flow‐Diverting Devices for Intracranial Aneurysms
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    International Journal for Numerical Methods in Biomedical Engineering 2024 40 12
  • Reliability and applicability of angiographic outcome scales in WEB device-treated aneurysms: a systematic review
    Pierre-Olivier Comby, Stefanos Finitsis, Daniela Iancu, Maria Alexandratou, Anass Benomar, Daniel Roy, Alain Weill, Roland Jabre, Nicolas Lecaros, Hanan Alhazmi, Tim E. Darsaut, Jean Raymond
    Neuroradiology 2025 67 1
  • Response to “Flow Diversion in the Treatment of Intracranial Aneurysms: A Pragmatic Randomized Care Trial”
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    American Journal of Neuroradiology 2023 44 1
  • Flow Diversion Versus Coiling in Small and Medium-sized Unruptured Aneurysms of Proximal Anterior Circulation with Complex Anatomy: a Matched-pairs Study.
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    Thanh Ngoc Nguyen
    CONTINUUM: Lifelong Learning in Neurology 2023 29 2
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J. Raymond, D. Iancu, W. Boisseau, J.D.B. Diestro, R. Klink, M. Chagnon, J. Zehr, B. Drake, H. Lesiuk, A. Weill, D. Roy, M.W. Bojanowski, C. Chaalala, J.L. Rempel, C. O’Kelly, M.M. Chow, S. Bracard, T.E. Darsaut
Flow Diversion in the Treatment of Intracranial Aneurysms: A Pragmatic Randomized Care Trial
American Journal of Neuroradiology Sep 2022, 43 (9) 1244-1251; DOI: 10.3174/ajnr.A7597

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Flow Diversion for Intracranial Aneurysms: A Trial
J. Raymond, D. Iancu, W. Boisseau, J.D.B. Diestro, R. Klink, M. Chagnon, J. Zehr, B. Drake, H. Lesiuk, A. Weill, D. Roy, M.W. Bojanowski, C. Chaalala, J.L. Rempel, C. O’Kelly, M.M. Chow, S. Bracard, T.E. Darsaut
American Journal of Neuroradiology Sep 2022, 43 (9) 1244-1251; DOI: 10.3174/ajnr.A7597
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Cited By...

  • Flow Diversion for the Treatment of Distal Circulation Aneurysms: A Randomized Comparison
  • Optimizing Photon-Counting Detector CT for Imaging Intracranial Aneurysms
  • Predictors of aneurysm occlusion after treatment with flow diverters: a systematic literature review
  • Predictors of aneurysm occlusion after treatment with flow diverters: a systematic literature review
  • Response to "Flow Diversion in the Treatment of Intracranial Aneurysms: A Pragmatic Randomized Care Trial"
  • Crossref (13)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Predictors of aneurysm occlusion after treatment with flow diverters: a systematic literature review
    Lukas Meyer, Christian Paul Stracke, Maxim Bester, Kevin M Kallmes, Kamil Zeleňák, Aymeric Rouchaud, Mario Martínez-Galdámez, Pascal Jabbour, Thanh N Nguyen, Adnan H Siddiqui, Jens Fiehler, Susanne Gellissen
    Journal of NeuroInterventional Surgery 2024 16 5
  • Understanding statistical populations and inferences
    Jean Raymond, Tim E. Darsaut
    Neurochirurgie 2025 71 1
  • Endovascular Parent Vessel Occlusion Versus Flow Diversion in the Treatment of Large and Giant Aneurysms: A Randomized Comparison
    William Boisseau, Tim E. Darsaut, Robert Fahed, Pierre Olivier Comby, Brian Drake, Howard Lesiuk, Jeremy L. Rempel, Cian J. O'Kelly, Michael M.C. Chow, Daniela E. Iancu, Daniel Roy, Alain Weill, Ruby Klink, Jean Raymond
    World Neurosurgery 2024 185
  • Optimizing Photon-Counting Detector CT for Imaging Intracranial Aneurysms
    Kishore Rajendran, Ajay A. Madhavan
    American Journal of Neuroradiology 2024 45 10
  • Surgical randomized trials: how to prevent the comic opera from becoming a tragedy
    Jean Raymond, Tim E. Darsaut
    Neurochirurgie 2024 70 4
  • Understanding crossovers and potential ways to mitigate the problem: Lessons from influential trials on lumbar microdiscectomy
    V.K.Y. Chan, T.E. Darsaut, C.S. Bailey, J. Raymond
    Neurochirurgie 2023 69 5
  • Understanding heterogeneity of pragmatic trial results and subgroup analyses: The FIAT example
    Jean Raymond, Tim E. Darsaut
    Neurochirurgie 2025 71 4
  • In Reply to the Letter to the Editor Regarding: “Endovascular Parent Vessel Occlusion Versus Flow Diversion in the Treatment of Large and Giant Aneurysms: A Randomized Comparison”
    William Boisseau, Tim E. Darsaut, Jean Raymond
    World Neurosurgery 2024 187
  • Modeling Fibrin Accumulation on Flow‐Diverting Devices for Intracranial Aneurysms
    Juan R. Cebral, Fernando Mut, Rainald Löhner, Laurel Marsh, Alireza Chitsaz, Cem Bilgin, Esref Bayraktar, David Kallmes, Ramanathan Kadirvel
    International Journal for Numerical Methods in Biomedical Engineering 2024 40 12
  • Reliability and applicability of angiographic outcome scales in WEB device-treated aneurysms: a systematic review
    Pierre-Olivier Comby, Stefanos Finitsis, Daniela Iancu, Maria Alexandratou, Anass Benomar, Daniel Roy, Alain Weill, Roland Jabre, Nicolas Lecaros, Hanan Alhazmi, Tim E. Darsaut, Jean Raymond
    Neuroradiology 2025 67 1

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