Normative Data for Brainstem Structures, the Midbrain-to-Pons Ratio, and the Magnetic Resonance Parkinsonism Index

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FIGURE.
T1WI showing the 1st, 5th, 50th, 95th, and 99th percentiles for the midbrain and pons area, MCP and SCP widths for men as a whole group, as well as the same structures for the one male patient with verified PSP. Measurements of these structures are shown for the 50th percentile, which are also presented in high resolution in the Online Supplemental Data. The 50th percentile equals the mean. The line A is drawn between the superior pontine notch and the inferior point of the quadrigeminal plate, while line B is parallel to line A starting at the inferior pontine notch.

Table 1:

Descriptives for all subjects and for each sex^{^a}

	All Subjects(n = 996)	Women(n = 527)	Men(n = 469)	P Value^{^b}	Cohen D
Age (yr)	59.0 (SD, 4.2)(50.5–66.8)	58.7 (SD, 4.3)(50.5–66.3)	59.2 (SD, 4.2)(51.0–66.8)	P = .103
Height^{^c} (cm)	171.2 (SD, 8.7)(148.4–196.7)	165.2 (SD, 5.8)(148.4–186.7)	178.0 (SD, 6.1)(161.9–196.7)	P < .001	2.17
Weight^{^c} (kg)	79.3 (SD, 13.5)(47.2–127.0)	72.6 (SD, 11.8)(47.2–119.6)	86.8 (SD, 11.1)(59.8–127.0)	P < .001	1.24
BMI^{^c}	27.0 (SD, 3.7)(18.3–41.7)	26.6 (SD, 4.1)(18.3–41.7)	27.4 (SD, 3.1)(19.6–40.1)	P < .001	0.21
Midbrain (mm²)	136.7 (SD, 20.5)(76.0–222.4)	136.7 (SD, 19.7)(81.9–211.9)	136.7 (SD, 21.4)(76.0–211.9)	P = .985
Pons (mm²)	542.2 (SD, 57.8)(386.5–812.5)	518.2 (SD, 47.8)(386.5–695.7)	569.1 (SD, 56.2)(416.5–812.5)	P < .001	0.98
MCP (mm)	9.4 (SD, 0.8)(5.3–13.0)	9.1 (SD, 0.8)(5.3–11.5)	9.7 (SD, 0.8)(6.8–13.0)	P < .001	0.76
SCP (mm)	3.8 (SD, 0.5)(2.5–5.5)	3.7 (SD, 0.5)(2.6–5.2)	3.9 (SD, 0.5)(2.5–5.5)	P < .001	0.44
M/P ratio	0.25 (SD, 0.04)(0.14–0.41)	0.26 (SD, 0.04)(0.15–0.41)	0.24 (SD, 0.03)(0.14–0.36)	P < .001	0.67
MRPI	10.0 (SD, 1.9)(5.5–18.1)	9.5 (SD, 1.7)(5.5–15.6)	10.6 (SD, 2.0)(6.1–18.1)	P < .001	0.59

Table 2:

Sex-specific percentiles in the different age groups