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Research ArticlePediatric Neuroimaging

Simultaneously Acquired MRI Arterial Spin-Labeling and Interictal FDG-PET Improves Diagnosis of Pediatric Temporal Lobe Epilepsy

A.M. Khalaf, H.R. Nadel and H.M. Dahmoush
American Journal of Neuroradiology March 2022, 43 (3) 468-473; DOI: https://doi.org/10.3174/ajnr.A7421
A.M. Khalaf
aFrom the Stanford University School of Medicine, Department of Radiology, Division of Nuclear Medicine & Molecular Imaging, Division of Pediatric Radiology, Division of Neuroimaging & Neurointervention, Stanford University, Stanford, California
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H.R. Nadel
aFrom the Stanford University School of Medicine, Department of Radiology, Division of Nuclear Medicine & Molecular Imaging, Division of Pediatric Radiology, Division of Neuroimaging & Neurointervention, Stanford University, Stanford, California
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H.M. Dahmoush
aFrom the Stanford University School of Medicine, Department of Radiology, Division of Nuclear Medicine & Molecular Imaging, Division of Pediatric Radiology, Division of Neuroimaging & Neurointervention, Stanford University, Stanford, California
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References

  1. 1.↵
    1. Miller GF,
    2. Coffield E,
    3. Leroy Z, et al
    . Prevalence and costs of five chronic conditions in children. J Sch Nurs 2016;32:357–64 doi:10.1177/1059840516641190 pmid:27044668
    CrossRefPubMed
  2. 2.↵
    1. Berg AT,
    2. Shinnar S,
    3. Levy SR, et al
    . Newly diagnosed epilepsy in children: presentation at diagnosis. Epilepsia 1999;40:445–52 doi:10.1111/j.1528-1157.1999.tb00739.x pmid:10219270
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Kwan P,
    2. Arzimanoglou A,
    3. Berg AT, et al
    . Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 2010;51:1069–77 doi:10.1111/j.1528-1167.2009.02397.x pmid:19889013
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Berg AT,
    2. Vickrey BG,
    3. Testa FM, et al
    . How long does it take for epilepsy to become intractable? A prospective investigation. Ann Neurol 2006;60:73–79 doi:10.1002/ana.20852 pmid:16685695
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Wirrell EC
    . Predicting pharmacoresistance in pediatric epilepsy. Epilepsia 2013;54(Suppl 2):19–22 doi:10.1111/epi.12179 pmid:23646966
    CrossRefPubMed
  6. 6.↵
    1. O'Brien TJ,
    2. Miles K,
    3. Ware R, et al
    . The cost-effective use of 18F-FDG PET in the presurgical evaluation of medically refractory focal epilepsy. J Nucl Med 2008;49:931–37 doi:10.2967/jnumed.107.048207 pmid:18483097
    Abstract/FREE Full Text
  7. 7.↵
    1. Rathore C,
    2. Dickson JC,
    3. Teotónio R, et al
    . The utility of 18F-fluorodeoxyglucose PET (FDG PET) in epilepsy surgery. Epilepsy Res 2014;108:1306–14 doi:10.1016/j.eplepsyres.2014.06.012 pmid:25043753
    CrossRefPubMed
  8. 8.↵
    1. Niu N,
    2. Xing H,
    3. Wu M, et al
    . Performance of PET imaging for the localization of epileptogenic zone in patients with epilepsy: a meta-analysis. Eur Radiol 2021;31:6353–66 doi:10.1007/s00330-020-07645-4 pmid:33523306
    CrossRefPubMed
  9. 9.↵
    1. Runge U,
    2. Kirsch G,
    3. Petersen B, et al
    . Ictal and interictal ECD-SPECT for focus localization in epilepsy. Acta Neurol Scand 1997;96:271–76 doi:10.1111/j.1600-0404.1997.tb00283.x pmid:9404995
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Grunwald F,
    2. Menzel C,
    3. Pavics L, et al
    . Ictal and interictal brain SPECT imaging in epilepsy using technetium-99m-ECD. J Nucl Med 1994;35:1896–1901 pmid:7989966
    Abstract/FREE Full Text
  11. 11.↵
    1. Detre JA,
    2. Leigh JS,
    3. Williams DS, et al
    . Perfusion imaging. Magn Reson Med 1992;23:37–45 doi:10.1002/mrm.1910230106 pmid:1734182
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Aslan S,
    2. Xu F,
    3. Wang PL, et al
    . Estimation of labeling efficiency in pseudocontinuous arterial spin labeling. Magn Reson Med 2010;63:765–71 doi:10.1002/mrm.22245 pmid:20187183
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Zeng JY,
    2. Hu XQ,
    3. Xu JF, et al
    . Diagnostic accuracy of arterial spin-labeling MR imaging in detecting the epileptogenic zone: systematic review and meta-analysis. AJNR Am J Neuroradiol 2021;42:1052–60 doi:10.3174/ajnr.a7061 pmid:33766822
    Abstract/FREE Full Text
  14. 14.↵
    1. Woods JG,
    2. Chappell MA,
    3. Okell TW
    . Designing and comparing optimized pseudo-continuous arterial spin labeling protocols for measurement of cerebral blood flow. Neuroimage 2020;223:117246 doi:10.1016/j.neuroimage.2020.117246 pmid:32853814
    CrossRefPubMed
  15. 15.↵
    1. Treves ST,
    2. Gelfand MJ,
    3. Fahey FH, et al
    . 2016 update of the North American Consensus Guidelines for Pediatric Administered Radiopharmaceutical Activities. J Nucl Med 2016;57:15N–18N pmid:27909182, 27037354
    FREE Full Text
  16. 16.↵
    1. Nam JM,
    2. Blackwelder WC
    . Analysis of the ratio of marginal probabilities in a matched-pair setting. Stat Med 2002;21:689–99 doi:10.1002/sim.1017 pmid:11870810
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Wang YH,
    2. An Y,
    3. Fan XT, et al
    . Comparison between simultaneously acquired arterial spin labeling and 18F-FDG PET in mesial temporal lobe epilepsy assisted by a PET/MR system and SEEG. Neuroimage Clin 2018;19:824–30 doi:10.1016/j.nicl.2018.06.008 pmid:30013926
    CrossRefPubMed
  18. 18.↵
    1. Storti SF,
    2. Boscolo Galazzo I,
    3. Del Felice A, et al
    . Combining ESI, ASL and PET for quantitative assessment of drug-resistant focal epilepsy. Neuroimage 2014;102:49–59 doi:10.1016/j.neuroimage.2013.06.028 pmid:23792219
    CrossRefPubMed
  19. 19.↵
    1. Sierra-Marcos A,
    2. Carreño M,
    3. Setoain X, et al
    . Accuracy of arterial spin labeling magnetic resonance imaging (MRI) perfusion in detecting the epileptogenic zone in patients with drug-resistant neocortical epilepsy: comparison with electrophysiological data, structural MRI, SISCOM and FDG-PET. Eur J Neurol 2016;23:160–67 doi:10.1111/ene.12826 pmid:26346555
    CrossRefPubMed
  20. 20.↵
    1. Boscolo Galazzo I,
    2. Mattoli MV,
    3. Pizzini FB, et al
    . Cerebral metabolism and perfusion in MR-negative individuals with refractory focal epilepsy assessed by simultaneous acquisition of 18F-FDG PET and arterial spin labeling. Neuroimage Clin 2016;11:648–57 doi:10.1016/j.nicl.2016.04.005 pmid:27222796
    CrossRefPubMed
  21. 21.↵
    1. Shang K,
    2. Wang J,
    3. Fan X, et al
    . Clinical value of hybrid TOF-PET/MR imaging-based multiparametric imaging in localizing seizure focus in patients with MRI-negative temporal lobe epilepsy. AJNR Am J Neuroradiol 2018;39:1791–98 doi:10.3174/ajnr.A5814 pmid:30237304
    Abstract/FREE Full Text
  22. 22.↵
    1. Drzezga A,
    2. Arnold S,
    3. Minoshima S, et al
    . 18F-FDG PET studies in patients with extratemporal and temporal epilepsy: evaluation of an observer-independent analysis. J Nucl Med 1999;40:737–46 pmid:10319744
    Abstract/FREE Full Text
  23. 23.↵
    1. Da Silva EA,
    2. Chugani DC,
    3. Muzik O, et al
    . Identification of frontal lobe epileptic foci in children using positron emission tomography. Epilepsia 1997;38:1198–1208 doi:10.1111/j.1528-1157.1997.tb01217.x pmid:9579921
    CrossRefPubMed
  24. 24.↵
    1. Qin Q,
    2. van Zijl PC
    . Velocity-selective-inversion prepared arterial spin labeling. Magn Reson Med 2016;76:1136–48 doi:10.1002/mrm.26010 pmid:26507471
    CrossRefPubMed
  25. 25.↵
    1. Yun TJ,
    2. Sohn CH,
    3. Yoo RE, et al
    . Transit time corrected arterial spin labeling technique aids to overcome delayed transit time effect. Neuroradiology 2018;60:255–65 doi:10.1007/s00234-017-1969-x pmid:29288284
    CrossRefPubMed
  26. 26.↵
    1. Fink GR,
    2. Pawlik G,
    3. Stefan H, et al
    . Temporal lobe epilepsy: Evidence for interictal uncoupling of blood flow and glucose metabolism in temporomesial structures. J Neurol Sci 1996;137:28–34 doi:10.1016/0022-510x(95)00323-t pmid:9120484
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Sone D,
    2. Maikusa N,
    3. Sato N, et al
    . Similar and differing distributions between 18F-FDG-PET and arterial spin labeling imaging in temporal lobe epilepsy. Front Neurol 2019;10:1–9 doi:10.3389/fneur.2019.00001 pmid:31001198
    CrossRefPubMed
  28. 28.↵
    1. Sander JW,
    2. Hart YM,
    3. Johnson AL, et al
    . National General Practice Study of Epilepsy: newly diagnosed epileptic seizures in a general population. Lancet 1990;336:1267–71 doi:10.1016/0140-6736(90)92959-L pmid:1978113
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Syvertsen M,
    2. Nakken KO,
    3. Edland A, et al
    . Prevalence and etiology of epilepsy in a Norwegian county: a population based study. Epilepsia 2015;56:699–706 doi:10.1111/epi.12972 pmid:25810072
    CrossRefPubMed
  30. 30.↵
    1. Delaney S,
    2. Fitzsimons M,
    3. White M, et al
    . Analysis of the aetiology of epilepsy in 3,216 adult patients attending a tertiary referral center enabled by an electronic patient record. Seizure 2020;81:332–37 doi:10.1016/j.seizure.2020.08.005 pmid:32883563
    CrossRefPubMed
  31. 31.↵
    1. Makki MI,
    2. O’Gorman RL,
    3. Buhler P, et al
    . Total cerebrovascular blood flow and whole brain perfusion in children sedated using propofol with or without ketamine at induction: An investigation with 2D-Cine PC and ASL. J Magn Reson Imaging 2019;50:1433–40 doi:10.1002/jmri.26725 pmid:30892782
    CrossRefPubMed
  32. 32.↵
    1. Yang Z
    . Impact of sevoflurane and propofol anesthesia on quality of [18F] FDG-PET scan image. SOJ Anesthesiol Pain Manag 2017;4:1–4 doi:10.15226/2374-684x/4/2/00146
    CrossRef
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A.M. Khalaf, H.R. Nadel, H.M. Dahmoush
Simultaneously Acquired MRI Arterial Spin-Labeling and Interictal FDG-PET Improves Diagnosis of Pediatric Temporal Lobe Epilepsy
American Journal of Neuroradiology Mar 2022, 43 (3) 468-473; DOI: 10.3174/ajnr.A7421

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Simultaneously Acquired MRI Arterial Spin-Labeling and Interictal FDG-PET Improves Diagnosis of Pediatric Temporal Lobe Epilepsy
A.M. Khalaf, H.R. Nadel, H.M. Dahmoush
American Journal of Neuroradiology Mar 2022, 43 (3) 468-473; DOI: 10.3174/ajnr.A7421
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