Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatrics
Open Access

Effects of Tissue Temperature and Injury on ADC during Therapeutic Hypothermia in Newborn Hypoxic-Ischemic Encephalopathy

C. Zenobi, J.L. Wisnowski, B. Tamrazi, A.M.-C. Wong, R. Chapman, S. Blüml and T.-W. Wu
American Journal of Neuroradiology March 2022, 43 (3) 462-467; DOI: https://doi.org/10.3174/ajnr.A7413
C. Zenobi
aFrom the Los Angeles County+USC Medical Center (C.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Zenobi
J.L. Wisnowski
bDepartments of Radiology and Pediatrics (J.L.W., B.T., S.B.)
dDivision of Neonatology (J.L.W., R.C., T.-W.W.), Fetal and Neonatal Institute
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.L. Wisnowski
B. Tamrazi
bDepartments of Radiology and Pediatrics (J.L.W., B.T., S.B.)
eDepartment of Radiology (B.T., S.B.), Children’s Hospital Los Angeles, Los Angeles, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B. Tamrazi
A.M.-C. Wong
fDepartment of Medical Imaging and Intervention (A.M.-C.W.), Chang Gung Memorial Hospital, Keelung/Linkou, Taiwan
gDepartment of Diagnostic Radiology (A.M.-C.W.), Chang Gung University, Taoyuan City, Taiwan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.M.-C. Wong
R. Chapman
dDivision of Neonatology (J.L.W., R.C., T.-W.W.), Fetal and Neonatal Institute
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Chapman
S. Blüml
bDepartments of Radiology and Pediatrics (J.L.W., B.T., S.B.)
cPediatrics (S.B., T.-W.W.), Keck School of Medicine of USC, Los Angeles, California
eDepartment of Radiology (B.T., S.B.), Children’s Hospital Los Angeles, Los Angeles, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Blüml
T.-W. Wu
cPediatrics (S.B., T.-W.W.), Keck School of Medicine of USC, Los Angeles, California
dDivision of Neonatology (J.L.W., R.C., T.-W.W.), Fetal and Neonatal Institute
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T.-W. Wu
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. de Vries LS,
    2. Jongmans MJ
    . Long-term outcome after neonatal hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 2010;95:F220–24 doi:10.1136/adc.2008.148205 pmid:20444814
    Abstract/FREE Full Text
  2. 2.↵
    1. Ferriero DM
    . Neonatal brain injury. N Engl J Med 2004;351:1985–95 doi:10.1056/NEJMra041996 pmid:15525724
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Shankaran S,
    2. Pappas A,
    3. McDonald SA, et al
    ; Eunice Kennedy Shriver NICHD Neonatal Research Network. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med 2012;366:2085–92 doi:10.1056/NEJMoa1112066 pmid:22646631
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Jacobs SE,
    2. Berg M,
    3. Hunt R, et al
    . Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 2013;1:CD003311 doi:10.1002/14651858.cd003311.pub3 pmid:17943788
    CrossRefPubMed
  5. 5.↵
    1. Ment LR,
    2. Bada HS,
    3. Barnes P, et al
    . Practice parameter: Neuroimaging of the Neonate—Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 2002;58:1726–38 doi:10.1212/WNL.58.12.1726 pmid:12084869
    Abstract/FREE Full Text
  6. 6.↵
    1. Barkovich AJ,
    2. Miller SP,
    3. Bartha A, et al
    . MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy. AJNR Am J Neuroradiol 2006;27:533–47 pmid:16551990
    PubMedWeb of Science
  7. 7.↵
    1. Ghei SK,
    2. Zan E,
    3. Nathan JE, et al
    . MR imaging of hypoxic-ischemic injury in term neonates: pearls and pitfalls. Radiographics 2014;34:1047–61 doi:10.1148/rg.344130080 pmid:25019441
    CrossRefPubMed
  8. 8.↵
    1. Rutherford M,
    2. Malamateniou C,
    3. McGuinness A, et al
    . Magnetic resonance imaging in hypoxic-ischaemic encephalopathy. Early Hum Dev 2010;86:351–60 doi:10.1016/j.earlhumdev.2010.05.014 pmid:20541877
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Neil JJ,
    2. Shiran SI,
    3. McKinstry RC, et al
    . Normal brain in human newborns: apparent diffusion coefficient and diffusion anisotropy measured by using diffusion tensor MR imaging. Radiology 1998;209:57–66 doi:10.1148/radiology.209.1.9769812 pmid:9769812
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Bihan DL,
    2. Delannoy J,
    3. Levin RL
    . Temperature mapping with MR imaging of molecular diffusion: application to hyperthermia. Radiology 1989;171:853–57 doi:10.1148/radiology.171.3.2717764 pmid:2717764
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Wu TW,
    2. Wisnowski JL,
    3. Geisler RF, et al
    . An in vivo assessment of regional brain temperature during whole-body cooling for neonatal encephalopathy. J Pediatr 2020;220:73–79.e3 doi:10.1016/j.jpeds.2020.01.019 pmid:32089332
    CrossRefPubMed
  12. 12.↵
    1. Wu TW,
    2. McLean C,
    3. Friedlich P, et al
    . Brain temperature in neonates with hypoxic-ischemic encephalopathy during therapeutic hypothermia. J Pediatr 2014;165:1129–34 doi:10.1016/j.jpeds.2014.07.022 pmid:25151196
    CrossRefPubMed
  13. 13.↵
    1. Boudes E,
    2. Tan X,
    3. Saint-Martin C, et al
    . MRI obtained during versus after hypothermia in asphyxiated newborns. Arch Dis Child Fetal Neonatal Ed 2015;100:F238–42 doi:10.1136/archdischild-2014-306550 pmid:25605620
    Abstract/FREE Full Text
  14. 14.↵
    1. Shetty AN,
    2. Lucke AM,
    3. Liu P, et al
    . Cerebral oxygen metabolism during and after therapeutic hypothermia in neonatal hypoxic–ischemic encephalopathy: a feasibility study using magnetic resonance imaging. Pediatr Radiol 2019;49:224–33 doi:10.1007/s00247-018-4283-9 pmid:30402807
    CrossRefPubMed
  15. 15.↵
    1. Wu TW,
    2. McLean C,
    3. Friedlich P, et al
    . Maintenance of whole-body therapeutic hypothermia during patient transport and magnetic resonance imaging. Pediatr Radiol 2014;44:613–17 doi:10.1007/s00247-013-2863-2 pmid:24442339
    CrossRefPubMed
  16. 16.↵
    1. Murakami T,
    2. Ogasawara K,
    3. Yoshioka Y, et al
    . Brain temperature measured by using proton MR spectroscopy predicts cerebral hyperperfusion after carotid endarterectomy. Radiology 2010;256:924–31 doi:10.1148/radiol.10090930 pmid:20720075
    CrossRefPubMed
  17. 17.↵
    1. Winter JD,
    2. Lee DS,
    3. Hung RM, et al
    . Apparent diffusion coefficient pseudonormalization time in neonatal hypoxic-ischemic encephalopathy. Pediatr Neurol 2007;37:255–62 doi:10.1016/j.pediatrneurol.2007.06.005 pmid:17903669
    CrossRefPubMed
  18. 18.↵
    1. Bednarek N,
    2. Mathur A,
    3. Inder T, et al
    . Impact of therapeutic hypothermia on MRI diffusion changes in neonatal encephalopathy. Neurology 2012;78:1420–27 doi:10.1212/WNL.0b013e318253d589 pmid:22517107
    Abstract/FREE Full Text
  19. 19.↵
    1. Hayakawa K,
    2. Koshino S,
    3. Tanda K, et al
    . Diffusion pseudonormalization and clinical outcome in term neonates with hypoxic–ischemic encephalopathy. Pediatr Radiol 2018;48:865–74 doi:10.1007/s00247-018-4094-z pmid:29417166
    CrossRefPubMed
  20. 20.↵
    1. Parker SJ,
    2. Kuzniewicz M,
    3. Niki H, et al
    . Antenatal and intrapartum risk factors for hypoxic-ischemic encephalopathy in a US birth cohort. J Pediatr 2018;203:163–69 doi:10.1016/j.jpeds.2018.08.028 pmid:30270166
    CrossRefPubMed
  21. 21.↵
    1. Vik T,
    2. Redline R,
    3. Nelson KB, et al
    . The placenta in neonatal encephalopathy: a case–control study. J Pediatr 2018;202:77–85.e3 doi:10.1016/j.jpeds.2018.06.005 pmid:30369428
    CrossRefPubMed
  22. 22.↵
    1. Wu YW,
    2. Goodman AM,
    3. Chang T, et al
    . Placental pathology and neonatal brain MRI in a randomized trial of erythropoietin for hypoxic–ischemic encephalopathy. Pediatr Res 2020;87:879–84 doi:10.1038/s41390-019-0493-6 pmid:31261373
    CrossRefPubMed
  23. 23.↵
    1. Modi N
    . Clinical implications of postnatal alterations in body water distribution. Semin Neonatol 2003;8:301–06 doi:10.1016/S1084-2756(03)00043-5 pmid:15001133
    CrossRefPubMed
  24. 24.↵
    1. Dudink J,
    2. Larkman DJ,
    3. Kapellou O, et al
    . High b-value diffusion tensor imaging of the neonatal brain at 3T. AJNR Am J Neuroradiol 2008;29:1966–72 doi:10.3174/ajnr.A1241 pmid:18687746
    Abstract/FREE Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 43 (3)
American Journal of Neuroradiology
Vol. 43, Issue 3
1 Mar 2022
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Effects of Tissue Temperature and Injury on ADC during Therapeutic Hypothermia in Newborn Hypoxic-Ischemic Encephalopathy
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
C. Zenobi, J.L. Wisnowski, B. Tamrazi, A.M.-C. Wong, R. Chapman, S. Blüml, T.-W. Wu
Effects of Tissue Temperature and Injury on ADC during Therapeutic Hypothermia in Newborn Hypoxic-Ischemic Encephalopathy
American Journal of Neuroradiology Mar 2022, 43 (3) 462-467; DOI: 10.3174/ajnr.A7413

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Effects of Tissue Temperature and Injury on ADC during Therapeutic Hypothermia in Newborn Hypoxic-Ischemic Encephalopathy
C. Zenobi, J.L. Wisnowski, B. Tamrazi, A.M.-C. Wong, R. Chapman, S. Blüml, T.-W. Wu
American Journal of Neuroradiology Mar 2022, 43 (3) 462-467; DOI: 10.3174/ajnr.A7413
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref (2)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Volpe's Neurology of the Newborn
    Linda S. de Vries, Joseph J. Volpe
    2025
  • Diffusion im Neugeborenen-Hirn während und nach der Hypothermiebehandlung
    Neuroradiologie Scan 2022 12 04

More in this TOC Section

Pediatrics

  • SyMRI & MR Fingerprinting in Brainstem Myelination
  • Comparison of Image Quality and Radiation Dose in Pediatric Temporal Bone CT Using Photon-Counting Detector CT and Energy-Integrating Detector CT
  • Dual-Layer Detector CT for PEDS Image Quality
Show more Pediatrics

Functional

  • Kurtosis and Epileptogenic Tubers: A Pilot Study
  • Glutaric Aciduria Type 1: DK vs. Conventional MRI
  • Predicting Outcomes in Tuberous Sclerosis Epilepsy
Show more Functional

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire