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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticlePediatric Neuroimaging

Accelerated Nonenhanced 3D T1-MPRAGE Using Wave-Controlled Aliasing in Parallel Imaging for Infant Brain Imaging

S.Y. Yun and Y.J. Heo
American Journal of Neuroradiology December 2022, 43 (12) 1797-1801; DOI: https://doi.org/10.3174/ajnr.A7680
S.Y. Yun
aFrom the Department of Radiology, Inje University Busan Paik Hospital, Busan, South Korea
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Y.J. Heo
aFrom the Department of Radiology, Inje University Busan Paik Hospital, Busan, South Korea
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    FIG 1.

    Term-equivalent-age MR imaging of a premature infant (29 weeks’ gestation). Nonenhanced standard MPRAGE images (A and C) show hyperintense germinal matrix hemorrhage (arrows) in the right caudothalamic groove and cystic changes of germinal matrix hemorrhage (arrowheads) in the left caudothalamic groove. Although wave-T1-MPRAGE images (B and D) demonstrate lower image quality than standard MPRAGE, both caudothalamic lesions are well-delineated in nonenhanced wave-T1-MPRAGE images.

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    FIG 2.

    Term-equivalent-age MR imaging of a premature infant (31 weeks’ gestation). Nonenhanced standard MPRAGE (A) shows decreased cerebral WM volume and a focal T1-hyperintense lesion (arrow) at the left corona radiata. The focal corona radiata lesion (arrows) demonstrates hypointensity on gradient recalled-echo (B) and T2-weighted (C) images. Although the wave-MPRAGE image (D) shows lower image quality than standard MPRAGE, the focal T1-hyperintense lesion (arrow) at the left corona radiata is also visible in the wave-MPRAGE image.

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    FIG 3.

    Term-equivalent-age MR imaging of a premature infant (33 weeks’ gestation). Nonenhanced standard MPRAGE images (A and C) show a focal hyperintense lesion (arrows) in the left periventricular WM. Although the wave-T1-MPRAGE images (B and D) also show the focal, hyperintense lesion (arrows) in the left periventricular WM, it is less prominently visualized than in the standard MPRAGE; thus, 1 observer missed the lesion.

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    FIG 4.

    Brain MR imaging of a premature infant (29 weeks’ gestation) 1 month after birth. Nonenhanced standard MPRAGE images (A–C) show severe motion artifacts, which are not acceptable for diagnostic use, while wave-T1-MPRAGE (D–F) shows mild motion artifacts, which are acceptable for diagnostic use.

Tables

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  • Image parameters of standard MPRAGE and wave-T1-MPRAGE

    Standard MPRAGEWave-T1-MPRAGE
    FOV (mm2)180 × 180180 × 80
    Voxel size (mm3)0.8 × 0.8 × 0.90.8 × 0.8 × 0.9
    TR (ms)24002200
    TE (ms)2.963.05
    Flip angle9°9°
    Bandwidth (Hz)260260
    TI (ms)12001090
    Number of excitations11
    Parallel imaging methodGRAPPAaCAIPIRINHAb
    Acceleration factor (phase)22
    Acceleration factor (section)–2
    Scan time4 min 55 sec2 min 14 sec
    • Note:—–indicates none.

    • ↵a Generalized autocalibrating partially parallel acquisition.

    • ↵b Controlled aliasing in parallel imaging results in higher acceleration.

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American Journal of Neuroradiology: 43 (12)
American Journal of Neuroradiology
Vol. 43, Issue 12
1 Dec 2022
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Cite this article
S.Y. Yun, Y.J. Heo
Accelerated Nonenhanced 3D T1-MPRAGE Using Wave-Controlled Aliasing in Parallel Imaging for Infant Brain Imaging
American Journal of Neuroradiology Dec 2022, 43 (12) 1797-1801; DOI: 10.3174/ajnr.A7680

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Accelerated 3D T1-MPRAGE for Infant Brain Imaging
S.Y. Yun, Y.J. Heo
American Journal of Neuroradiology Dec 2022, 43 (12) 1797-1801; DOI: 10.3174/ajnr.A7680
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