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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticlePediatric Neuroimaging

Arterial Spin-Labeling Perfusion Metrics in Pediatric Posterior Fossa Tumor Surgery

S.M. Toescu, P.W. Hales, J. Cooper, E.W. Dyson, K. Mankad, J.D. Clayden, K. Aquilina and C.A. Clark
American Journal of Neuroradiology October 2022, 43 (10) 1508-1515; DOI: https://doi.org/10.3174/ajnr.A7637
S.M. Toescu
aFrom the Departments of Neurosurgery (S.M.T., E.W.D., K.A.)
cDevelopmental Imaging and Biophysics Section (S.M.T., P.W.H., J.D.C.), University College London Great Ormond Street Institute of Child Health, London, UK
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P.W. Hales
cDevelopmental Imaging and Biophysics Section (S.M.T., P.W.H., J.D.C.), University College London Great Ormond Street Institute of Child Health, London, UK
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J. Cooper
bNeuroradiology (J.C., K.M., C.A.C.), Great Ormond Street Hospital, London, UK
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E.W. Dyson
aFrom the Departments of Neurosurgery (S.M.T., E.W.D., K.A.)
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K. Mankad
bNeuroradiology (J.C., K.M., C.A.C.), Great Ormond Street Hospital, London, UK
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J.D. Clayden
cDevelopmental Imaging and Biophysics Section (S.M.T., P.W.H., J.D.C.), University College London Great Ormond Street Institute of Child Health, London, UK
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K. Aquilina
aFrom the Departments of Neurosurgery (S.M.T., E.W.D., K.A.)
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C.A. Clark
bNeuroradiology (J.C., K.M., C.A.C.), Great Ormond Street Hospital, London, UK
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References

  1. 1.↵
    1. Johnston IH,
    2. Rowan JO,
    3. Harper AM, et al
    . Raised intracranial pressure and cerebral blood flow, I: cisterna magna infusion in primates. J Neurol Neurosurg Psychiatry 1972;35:285–96 doi:10.1136/jnnp.35.3.285 pmid:4624687
    Abstract/FREE Full Text
  2. 2.
    1. Johnston IH,
    2. Rowan JO
    . Raised intracranial pressure and cerebral blood flow, 4: intracranial pressure gradients and regional cerebral blood flow. J Neurol Neurosurg Psychiatry 1974;37:585–92 doi:10.1136/jnnp.37.5.585 pmid:4836754
    Abstract/FREE Full Text
  3. 3.↵
    1. Grubb RL,
    2. Raichle ME,
    3. Phelps ME, et al
    . Effects of increased intracranial pressure on cerebral blood volume, blood flow, and oxygen utilization in monkeys. J Neurosurg 1975;43:385–98 doi:10.3171/jns.1975.43.4.0385 pmid:808593
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Jabre A,
    2. Symon L,
    3. Richards PG, et al
    . Mean hemispheral cerebral blood flow changes after craniotomy: significance and prognostic value. Acta Neurochir (Wien) 1985;78:13–20 doi:10.1007/BF01809235 pmid:4072786
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Kerscher S,
    2. Schoning M,
    3. Schuhmann M
    . Raised ICP decreases cerebral blood flow volume in pediatric patients. In: Proceedings of the Annual Meeting of the International Society for Paediatric Neurosurgery, Birmingham, UK. October 20–24, 2019
  6. 6.↵
    1. Toescu S,
    2. Samarth G,
    3. Layard Horsfall H, et al
    . Fourth ventricle tumours in children: complications and influence of surgical approach. J Neurosurg Pediatr 2020;27:52–61 doi:10.3171/2020.6.PEDS2089] pmid:33096529
    CrossRefPubMed
  7. 7.↵
    1. Yeom KW,
    2. Lober RM,
    3. Alexander A, et al
    . Hydrocephalus decreases arterial spin-labeled cerebral perfusion. AJNR Am J Neuroradiol 2014;35:1433–39 doi:10.3174/ajnr.A3891 pmid:24651817
    Abstract/FREE Full Text
  8. 8.↵
    1. Keil VC,
    2. Hartkamp NS,
    3. Connolly DJ, et al
    . Added value of arterial spin labeling magnetic resonance imaging in pediatric neuroradiology: pitfalls and applications. Pediatr Radiol 2019;49:245–53 doi:10.1007/s00247-018-4269-7 pmid:30448868
    CrossRefPubMed
  9. 9.↵
    1. Robertson PL,
    2. Muraszko KM,
    3. Holmes EJ, et al
    ; Children’s Oncology Group. Incidence and severity of postoperative cerebellar mutism syndrome in children with medulloblastoma: a prospective study by the Children’s Oncology Group. J Neurosurg 2006;105:444–51 doi:10.3171/ped.2006.105.6.444 pmid:17184075
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Gudrunardottir T,
    2. Sehested A,
    3. Juhler M, et al
    . Cerebellar mutism: definitions, classification and grading of symptoms. Childs Nerv Syst 2011;27:1361–63 doi:10.1007/s00381-011-1509-7 pmid:21732118
    CrossRefPubMed
  11. 11.↵
    1. Germanò A,
    2. Baldari S,
    3. Caruso G, et al
    . Reversible cerebral perfusion alterations in children with transient mutism after posterior fossa surgery. Childs Nerv Syst 1998;14:114–19 doi:10.1007/s003810050191 pmid:9579866
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. De Smet HJ,
    2. Baillieux H,
    3. Wackenier P, et al
    . Long-term cognitive deficits following posterior fossa tumor resection: a neuropsychological and functional neuroimaging follow-up study. Neuropsychology 2009;23:694–704 doi:10.1037/a0016106 pmid:19899828
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Miller NG,
    2. Reddick WE,
    3. Kocak M, et al
    . Cerebellocerebral diaschisis is the likely mechanism of postsurgical posterior fossa syndrome in pediatric patients with midline cerebellar tumors. AJNR Am J Neuroradiol 2010;31:288–94 doi:10.3174/ajnr.A1821
    Abstract/FREE Full Text
  14. 14.↵
    1. Yecies D,
    2. Shpanskaya K,
    3. Jabarkheel R, et al
    . Arterial spin-labeling perfusion changes of the frontal lobes in children with posterior fossa syndrome. J Neurosurg Pediatr 2019 Aug 2. [Epub ahead of pirnt] doi:10.3171/2019.5.PEDS18452 pmid:31860810
    CrossRefPubMed
  15. 15.↵
    1. Watanabe Y,
    2. Yamasaki F,
    3. Nakamura K, et al
    . Evaluation of cerebellar mutism by arterial spin-labeling perfusion magnetic resonance imaging in a patient with atypical teratoid/rhabdoid tumor (AT/RT): a case report. Childs Nerv Syst 2012;28:1257–60 doi:10.1007/s00381-012-1741-9 pmid:22476660
    CrossRefPubMed
  16. 16.↵
    1. Alsop DC,
    2. Detre JA,
    3. Golay X, et al
    . Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med 2015;73:102–16 doi:10.1002/mrm.25197 pmid:24715426
    CrossRefPubMed
  17. 17.↵
    1. Dale AM,
    2. Fischl B,
    3. Sereno MI
    . Cortical surface-based analysis. Neuroimage 1999;9:179–94 doi:10.1006/nimg.1998.0395 pmid:9931268
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Modat M,
    2. Cash DM,
    3. Daga P, et al
    . Global image registration using a symmetric block-matching approach. J Med Imaging (Bellingham) 2014;1:024003 doi:10.1117/1.JMI.1.2.024003 pmid:26158035
    CrossRefPubMed
  19. 19.↵
    1. Buxton RB,
    2. Frank LR,
    3. Wong EC, et al
    . A general kinetic model for quantitative perfusion imaging with arterial spin-labeling. Magn Reson Med 1998;40:383–96 doi:10.1002/mrm.1910400308 pmid:9727941
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Hales PW,
    2. Kawadler JM,
    3. Aylett SE, et al
    . Arterial spin-labeling characterization of cerebral perfusion during normal maturation from late childhood into adulthood: normal “reference range” values and their use in clinical studies. J Cereb Blood Flow Metab 2014;34:776–84 doi:10.1038/jcbfm.2014.17 pmid:24496173
    CrossRefPubMed
  21. 21.↵
    1. Jenkinson M,
    2. Bannister P,
    3. Brady M, et al
    . Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 2002;17:825–41 doi:10.1006/nimg.2002.1132 pmid:12377157
    CrossRefPubMedWeb of Science
  22. 22.↵
    R Core Team. A language and environment for statistical computing. R Foundation for Statistical Computing; 2017. https://www.r-project.org/. Accessed March 3, 2020
  23. 23.↵
    1. Barton K
    . MuMIn: Multi-Model Inference. 2020. https://cran.microsoft.com/snapshot/2020-11-30/web/packages/MuMIn/index.html. Accessed March 3, 2020
  24. 24.↵
    1. Rao VK,
    2. Haridas A,
    3. Nguyen TT, et al
    . Symptomatic cerebral vasospasm following resection of a medulloblastoma in a child. Neurocrit Care 2013;18:84–88 doi:10.1007/s12028-012-9769-y pmid:22911499
    CrossRefPubMed
  25. 25.↵
    1. Gocmen S,
    2. Acka G,
    3. Karaman K, et al
    . Cerebral vasospasm after posterior fossa tumor surgery: a case report and literature review. Pediatr Neurosurg 2020;55:393–96 doi:10.1159/000511879 pmid:33302279
    CrossRefPubMed
  26. 26.↵
    1. Deghedy M,
    2. Pizer B,
    3. Kumar R, et al
    . Basilar artery vasospasm as a cause of post-operative cerebellar mutism syndrome. Case Rep Pediatr 2022;2022:9148100–05 doi:10.1155/2022/9148100 pmid:35186341
    CrossRefPubMed
  27. 27.↵
    1. Lin CT,
    2. Riva-Cambrin JK
    . Management of posterior fossa tumors and hydrocephalus in children: a review. Childs Nerv Syst 2015;31:1781–89 doi:10.1007/s00381-015-2781-8 pmid:26351230
    CrossRefPubMed
  28. 28.↵
    1. Borgesen SE,
    2. Gjerris F
    . Relationships between intracranial pressure, ventricular size, and resistance to CSF outflow. J Neurosurg 1987;67:535–39 doi:10.3171/jns.1987.67.4.0535 pmid:3655891
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Ahmadian N,
    2. van Baarsen M,
    3. Robe, PA, et al
    . Association between cerebral perfusion and paediatric postoperative cerebellar mutism syndrome after posterior fossa surgery: a systematic review. Childs Nerv Syst 2021;37:2742–51 doi:10.1007/S00381-021-05225-5 pmid:34155533
    CrossRefPubMed
  30. 30.↵
    1. Hartkamp NS,
    2. Petersen ET,
    3. De Vis JB, et al
    . Mapping of cerebral perfusion territories using territorial arterial spin-labeling: techniques and clinical application. NMR Biomed 2013;26:901–12 doi:10.1002/nbm.2836 pmid:22807022
    CrossRefPubMed
  31. 31.↵
    1. Pang D,
    2. Altschuler E
    . Low-pressure hydrocephalic state and viscoelastic alterations in the brain. Neurosurgery 1994;35:643–56 doi:10.1227/00006123-199410000-00010 pmid:7808607
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Virhammar XJ,
    2. Laurell XK,
    3. Ahlgren XA, et al
    . Arterial spin-labeling perfusion MR imaging demonstrates regional CBF decrease in idiopathic normal pressure hydrocephalus. AJNR Am J Neuroradiol 2017;38:2081–88 doi:10.3174/ajnr.A5347 pmid:28860216
    Abstract/FREE Full Text
  33. 33.↵
    1. Virhammar J,
    2. Ahlgren A,
    3. Cesarini KG, et al
    . Cerebral perfusion does not increase after shunt surgery for normal pressure hydrocephalus. J Neuroimaging 2020;30:303–07 doi:10.1111/jon.12702 pmid:32374437
    CrossRefPubMed
  34. 34.↵
    1. Li MD,
    2. Forkert ND,
    3. Kundu P, et al
    . Brain perfusion and diffusion abnormalities in children treated for posterior fossa brain tumors. J Pediatr 2017;185:173–80.e3 doi:10.1016/j.jpeds.2017.01.019 pmid:28187964
    CrossRefPubMed
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S.M. Toescu, P.W. Hales, J. Cooper, E.W. Dyson, K. Mankad, J.D. Clayden, K. Aquilina, C.A. Clark
Arterial Spin-Labeling Perfusion Metrics in Pediatric Posterior Fossa Tumor Surgery
American Journal of Neuroradiology Oct 2022, 43 (10) 1508-1515; DOI: 10.3174/ajnr.A7637

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ASL Perfusion Metrics in PEDS Tumor Surgery
S.M. Toescu, P.W. Hales, J. Cooper, E.W. Dyson, K. Mankad, J.D. Clayden, K. Aquilina, C.A. Clark
American Journal of Neuroradiology Oct 2022, 43 (10) 1508-1515; DOI: 10.3174/ajnr.A7637
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