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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatrics

Intracranial Hemorrhage in Term and Late-Preterm Neonates: An Institutional Perspective

A.G. Sandoval Karamian, Q.-Z. Yang, L.T. Tam, V.L. Rao, E. Tong and K.W. Yeom
American Journal of Neuroradiology October 2022, 43 (10) 1494-1499; DOI: https://doi.org/10.3174/ajnr.A7642
A.G. Sandoval Karamian
aFrom the Division of Child Neurology (A.G.S.K.), University of Utah, Salt Lake City, Utah
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Q.-Z. Yang
bDivision of Child Neurology (Q.-Z.Y.), University of North Carolina, Chapel Hill, North Carolina
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L.T. Tam
cStanford University School of Medicine (L.T.T., V.L.R.), Palo Alto, California
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V.L. Rao
cStanford University School of Medicine (L.T.T., V.L.R.), Palo Alto, California
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E. Tong
dDepartment of Radiology (E.T., K.W.Y.), Lucile Packard Children’s Hospital, Stanford University, Palo Alto, California
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K.W. Yeom
dDepartment of Radiology (E.T., K.W.Y.), Lucile Packard Children’s Hospital, Stanford University, Palo Alto, California
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  • FIG 1.
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    FIG 1.

    Examples of various anatomic distributions of intracranial hemorrhages in term or late-preterm neonates. A, IVH and associated ventriculomegaly are present. Tentorial subdural hemorrhage is also present, as well as hemorrhage overlying the bilateral temporal poles. Right temporal lobe swelling (asterisk) is present and associated with subpial hemorrhage (arrow). B, Left occipital subpial hemorrhage (single arrow) is present, as well as left parieto-occipital lobe parenchymal hemorrhage (asterisk). Linear low signal intensities (double arrows) suggest either venous congestion or thromboses. C, Intra- and periventricular hemorrhages are present. Linear intensities (black arrow) and nodular intensities (white arrows on T2* imaging) suggest a perimedullary vein congestion and/or thromboses. D, Subpial hemorrhage is seen (white arrow) with subjacent temporal lobe deformity and edema (black arrow). On T2* imaging, parenchymal hemorrhage is also seen (asterisk), as well as punctate intraventricular blood products. E, Combined left frontal subpial and parenchymal hemorrhages are shown on CT and MR imaging. Small falcine subdural hemorrhage is also shown (arrow). F, Bilateral cerebral convexity, posterior fossa, and tentorial subdural hemorrhages (arrows) are present in a neonate with hemophilia.

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    FIG 2.

    Distribution of hemorrhages by CNS location. SDH indicates subdural hemorrhage.

  • FIG 3.
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    FIG 3.

    Distribution of hemorrhages by CNS location, subdivided by a combination of compartments when multiple compartments were involved. SDH indicates subdural hemorrhage.

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    Table 1:

    Sample characteristics

    VariableResult
    GA (median) (IQR) (wk)38.3 (37.0–39.8)
    Birth weight (mean) (SD) (kg)3.1 (0.7)
    Maternal age (median) (IQR) (yr)31 (28.0–34.0)
    Cesarean delivery (No.) (%)20 (32)
     Scheduled (No.) (%)9 (45)
     Urgent (No.) (%)11 (55)
    Instrumented delivery (No.) (%)5 (8)
    Apgar at 1 minute (median) (IQR)7 (2–8)
    Apgar at 5 minutes (median) (IQR)9 (7–9)
    HIE as indication for MR imaging (No.) (%)11 (17)
    Seizure as indication for MR imaging, (No.) (%)15 (24)
    Sepsis/meningitis (No.) (%)5 (8)
    • Note:—HIE indicates hypoxic-ischemic encephalopathy.

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    Table 2:

    Venous thromboses and thrombocytopenia/coagulopathy in neonates with ICH

    VariableResult
    Cortical vein thromboses present (No.) (%)34 (54)
    Periventricular or medullary vein thromboses present (No.) (%)37 (59)
    CVST present (No.) (%)5 (8)
    MRA performed (No.) (%)26 (41)
     MRA, abnormal finding (No.) (%)2 (3)
    MRV performed (No.) (%)27 (43)
     MRV, abnormal findings (No.) (%)5 (8)
    Platelet count (median) (IQR) ( × 103/μL)186 (147–271)
     Platelet count <100 × 103/μL (No.) (%)3 (5)
    INR (median) (IQR)1.2 (1.1–1.4)
     INR >1.2 (No.) (%)22 (35)
     INR >1.4 (No.) (%)9 (14)
    PTT (median) (IQR) (sec)37.4 (32.1–41.9)
     PTT >35.7 sec (No.) (%)26 (41)
    Fibrinogen level (median) (IQR) (mg/dL)266 (216–392.5)
     Fibrinogen level <234 mg/dL (No.) (%)15 (24)
     Fibrinogen level <150 mg/dL (No.) (%)3 (5)
    • Note:—CVST indicates cerebral venous sinus thrombosis; PTT, partial thromboplastin time.

    • View popup
    Table 3:

    Thromboses and coagulopathy by bleed location

    Hemorrhage LocationThrombosis (No.) (%)aIncreased Bleeding Risk (No.) (%)a
    Cortical Vein AlonePeriventricular Vein AloneBoth Cortical and Periventricular VeinsCVSTCoagulopathybThrombocytopeniac
    IVH (n = 41)4 (10)9 (22)17 (41)5 (12)9 (22)2 (5)
    SDH (n = 39)7 (18)9 (23)17 (44)2 (5)12 (31)1 (3)
    Subpial (n = 19)4 (21)7 (37)4 (21)2 (11)3 (16)0 (0)
    SAH (n = 12)4 (33)1 (8)3 (25)0 (0)3 (25)1 (8)
    IPH (n = 33)5 (15)9 (27)16 (48)3 (9)8 (24)3 (9)
    Epidural (n = 2)0 (0)0 (0)1 (50)0 (0)0 (0)0 (0)
    Multiple compartments (n = 52)d8 (15)9 (17)23 (44)3 (6)12 (23)3 (6)
    • Note:—SDH indicates subdural hemorrhage.

    • ↵a Percentages are row-based.

    • ↵b INR >1.4 and/or fibrinogen level < 150 mg/dL.

    • ↵c Platelet count < 100 × 103/uL.

    • ↵d Most of the sample (83%) had hemorrhages in multiple compartments.

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American Journal of Neuroradiology: 43 (10)
American Journal of Neuroradiology
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1 Oct 2022
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A.G. Sandoval Karamian, Q.-Z. Yang, L.T. Tam, V.L. Rao, E. Tong, K.W. Yeom
Intracranial Hemorrhage in Term and Late-Preterm Neonates: An Institutional Perspective
American Journal of Neuroradiology Oct 2022, 43 (10) 1494-1499; DOI: 10.3174/ajnr.A7642

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Intracranial Hemorrhage in Neonates
A.G. Sandoval Karamian, Q.-Z. Yang, L.T. Tam, V.L. Rao, E. Tong, K.W. Yeom
American Journal of Neuroradiology Oct 2022, 43 (10) 1494-1499; DOI: 10.3174/ajnr.A7642
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