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Research ArticlePediatrics

Evaluation of Posterior Fossa Biometric Measurements on Fetal MRI in the Evaluation of Dandy-Walker Continuum

U.D. Nagaraj, B.M. Kline-Fath, P.S. Horn and C. Venkatesan
American Journal of Neuroradiology September 2021, 42 (9) 1716-1721; DOI: https://doi.org/10.3174/ajnr.A7215
U.D. Nagaraj
aFrom the Departments of Radiology and Medical Imaging (U.D.N., B.M.K.-F.)
cUniversity of Cincinnati College of Medicine (U.D.N., B.M.K.-F., P.S.H., C.V.), Cincinnati, Ohio
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B.M. Kline-Fath
aFrom the Departments of Radiology and Medical Imaging (U.D.N., B.M.K.-F.)
cUniversity of Cincinnati College of Medicine (U.D.N., B.M.K.-F., P.S.H., C.V.), Cincinnati, Ohio
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P.S. Horn
bNeurology (P.S.H., C.V.), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
cUniversity of Cincinnati College of Medicine (U.D.N., B.M.K.-F., P.S.H., C.V.), Cincinnati, Ohio
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C. Venkatesan
bNeurology (P.S.H., C.V.), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
cUniversity of Cincinnati College of Medicine (U.D.N., B.M.K.-F., P.S.H., C.V.), Cincinnati, Ohio
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  • FIG 1.
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    FIG 1.

    Examples from cohort of Dandy-Walker continuum with TVAs. Sagittal (A) and axial (D) T2 single-shot FSE images from fetal MR imaging at 30 weeks’ GA demonstrate a BP with elevated TVA at 24°; however, the vermis is normal in size and morphology. Sagittal (B) and axial (E) T2 single-shot FSE images from fetal MR imaging at 32 weeks’ GA with VH. There is a coexisting BP marked by an elevated TVA; however, the tentorium is not considered elevated. Sagittal (C) and axial (F) T2 single-shot FSE images from fetal MR imaging at 24 weeks’ GA with classic DWM. The vermis is very small and rotated, and the tentorium is elevated with upward displacement. There is also separation and flattening of the cerebellar hemispheres (F, arrows).

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    FIG 2.

    Measurements of the patients included in this cohort for AP pons (A), AP vermis (B), CC vermis (C), and TCD (D) plotted in relation to the normal growth curves by GA.

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  • Average measurements in each category

    DWM (n = 7)VH (n = 16)BP (n = 10)
    TCD (mm)24.71 (SD, 4.46)24.88 (SD, 7.63)31.8 (SD, 11.41)
    Vermis height (mm)7.67 (SD, 3.08) (n = 6)10.69 (SD, 2.82)13.7 (SD, 5.44)
    AP vermis (mm)2.83 (SD, 1.33) (n = 6)5.56 (SD, 2.45)8.0 (SD, 3.5)
    TVA109.5° (SD, 20.21°) (n = 6)52.13° (SD, 18.88°)32.1° (SD, 17.9°)
    Cisterna magna enlarged7 (100%)11 (68.75%)5 (50%)
    AP pons (mm)5.4 (2–7)7.25 (SD, 1.77)9.4 (SD, 2.8)
    Posterior fossa angle130.86° (SD, 21.27°)108.75° (SD, 22.83°)91.1°(SD, 12.5°)
    Lateral ventricle size (mm)20.86 (SD, 8.88)8.63 (SD, 3.34)11.7 (SD, 8.1)
    Abnormal vermian foliation7 (100%) (n = 6)13 (81.25%)3 (30%)
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American Journal of Neuroradiology: 42 (9)
American Journal of Neuroradiology
Vol. 42, Issue 9
1 Sep 2021
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Cite this article
U.D. Nagaraj, B.M. Kline-Fath, P.S. Horn, C. Venkatesan
Evaluation of Posterior Fossa Biometric Measurements on Fetal MRI in the Evaluation of Dandy-Walker Continuum
American Journal of Neuroradiology Sep 2021, 42 (9) 1716-1721; DOI: 10.3174/ajnr.A7215

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Evaluation of Posterior Fossa Biometric Measurements on Fetal MRI in the Evaluation of Dandy-Walker Continuum
U.D. Nagaraj, B.M. Kline-Fath, P.S. Horn, C. Venkatesan
American Journal of Neuroradiology Sep 2021, 42 (9) 1716-1721; DOI: 10.3174/ajnr.A7215
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