Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatrics

Synthetic MRI in Neurofibromatosis Type 1

G. Coban, S. Parlak, E. Gumeler, H. Altunbuker, B. Konuşkan, J. Karakaya, B. Anlar and K.K. Oguz
American Journal of Neuroradiology September 2021, 42 (9) 1709-1715; DOI: https://doi.org/10.3174/ajnr.A7214
G. Coban
aFrom the Departments of Radiology (G.C., S.P., E.G., K.K.O.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Coban
S. Parlak
aFrom the Departments of Radiology (G.C., S.P., E.G., K.K.O.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Parlak
E. Gumeler
aFrom the Departments of Radiology (G.C., S.P., E.G., K.K.O.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Gumeler
H. Altunbuker
dIstanbul Il Ambulans Servisi Başhekimliği, (H.A.), Istanbul, Turkey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for H. Altunbuker
B. Konuşkan
eDepartment of Pediatric Neurology (B.K.), Mardin State Hospital, Mardin, Turkey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B. Konuşkan
J. Karakaya
bBiostatistics (J.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Karakaya
B. Anlar
cPediatric Neurology (B.A.), Hacettepe University School of Medicine, Ankara, Turkey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B. Anlar
K.K. Oguz
aFrom the Departments of Radiology (G.C., S.P., E.G., K.K.O.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K.K. Oguz
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Van Es S,
    2. North KN,
    3. McHugh K, et al
    . MRI findings in children with neurofibromatosis type 1: a prospective study. Pediatr Radiol 1996;26:478–87 doi:10.1007/BF01377205 pmid:8662066
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. The I,
    2. Hannigan GE,
    3. Cowley GS, et al
    . Rescue of a Drosophila NF1 mutant phenotype by protein kinase A. Science 1997;276:791–94 doi:10.1126/science.276.5313.791 pmid:9115203
    Abstract/FREE Full Text
  3. 3.↵
    1. Moore BD 3rd.,
    2. Slopis JM,
    3. Jackson EF, et al
    . Brain volume in children with neurofibromatosis type 1: relation to neuropsychological status. Neurology 2000;54:914–20 doi:10.1212/WNL.54.4.914 pmid:10690986
    Abstract/FREE Full Text
  4. 4.↵
    1. López-Juárez A,
    2. Titus HE,
    3. Silbak SH, et al
    . Oligodendrocyte Nf1 controls aberrant notch activation and regulates myelin structure and behavior. Cell Rep 2017;19:545–57 doi:10.1016/j.celrep.2017.03.073 pmid:28423318
    CrossRefPubMed
  5. 5.↵
    1. DiPaolo DP,
    2. Zimmerman RA,
    3. Rorke LB, et al
    . Neurofibromatosis type 1: pathologic substrate of high-signal-intensity foci in the brain. Radiology 1995;195:721–24 doi:10.1148/radiology.195.3.7754001
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Menor F,
    2. Marti-Bonmati L,
    3. Arana E, et al
    . Neurofibromatosis type 1 in children: MR imaging and follow-up studies of central nervous system findings. Eur J Radiol 1998;26:121–31 doi:10.1016/S0720-048X(97)00088-0 pmid:9518221
    CrossRefPubMed
  7. 7.↵
    1. Warntjes JB,
    2. Leinhard OD,
    3. West J, et al
    . Rapid magnetic resonance quantification on the brain: optimization for clinical usage. Magn Reson Med 2008;60:320–29 doi:10.1002/mrm.21635 pmid:18666127
    CrossRefPubMed
  8. 8.↵
    1. Krauss W,
    2. Gunnarsson M,
    3. Andersson T, et al
    . Accuracy and reproducibility of a quantitative magnetic resonance imaging method for concurrent measurements of tissue relaxation times and proton density. Magn Reson Imaging 2015;33:584–91 doi:10.1016/j.mri.2015.02.013 pmid:25708264
    CrossRefPubMed
  9. 9.↵
    1. Hagiwara A,
    2. Hori M,
    3. Yokoyama K, et al
    . Utility of a multiparametric quantitative MRI model that assesses myelin and edema for evaluating plaques, periplaque white matter, and normal-appearing white matter in patients with multiple sclerosis: a feasibility study. AJNR Am J Neuroradiol 2017;38:237–42 doi:10.3174/ajnr.A4977 pmid:27789453
    Abstract/FREE Full Text
  10. 10.↵
    1. Andica C,
    2. Hagiwara A,
    3. Nakazawa M, et al
    . The advantage of synthetic MRI for the visualization of early white matter change in an infant with Sturge-Weber syndrome. Magn Reson Med Sci 2016;15:347–48 doi:10.2463/mrms.ci.2015-0164 pmid:27001386
    CrossRefPubMed
  11. 11.↵
    1. Virhammar J,
    2. Warntjes M,
    3. Laurell K, et al
    . Quantitative MRI for rapid and user-independent monitoring of intracranial CSF volume in hydrocephalus. AJNR Am J Neuroradiol 2016;37:797–801 doi:10.3174/ajnr.A4627 pmid:26705322
    Abstract/FREE Full Text
  12. 12.↵
    1. Krauss W,
    2. Gunnarsson M,
    3. Nilsson M, et al
    . Conventional and synthetic MRI in multiple sclerosis: a comparative study. Eur Radiol 2018;28:1692–700 doi:10.1007/s00330-017-5100-9 pmid:29134354
    CrossRefPubMed
  13. 13.↵
    1. Sevick RJ,
    2. Barkovich AJ,
    3. Edwards MS, et al
    . Evolution of white matter lesions in neurofibromatosis type 1: MR findings. AJR Am J Roentgenol 1992;159:171–75 doi:10.2214/ajr.159.1.1609692 pmid:1609692
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Andica C,
    2. Hagiwara A,
    3. Hori M, et al
    . Automated brain tissue and myelin volumetry based on quantitative MR imaging with various in-plane resolutions. J Neuroradiol 2018;45:164–68 doi:10.1016/j.neurad.2017.10.002 pmid:29132939
    CrossRefPubMed
  15. 15.↵
    1. Warntjes M,
    2. Engström M,
    3. Tisell A, et al
    . Modeling the presence of myelin and edema in the brain based on multi-parametric quantitative MRI. Front Neurol 2016;7:16 doi:10.3389/fneur.2016.00016 pmid:26925030
    CrossRefPubMed
  16. 16.↵
    1. Benjamini Y,
    2. Hochberg Y
    . Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society Series B 1995;57:289–300
    CrossRefWeb of Science
  17. 17.↵
    1. Blystad I,
    2. Warntjes JB,
    3. Smedby O, et al
    . Synthetic MRI of the brain in a clinical setting. Acta Radiol 2012;53:1158–63 doi:10.1258/ar.2012.120195 pmid:23024181
    CrossRefPubMed
  18. 18.↵
    1. Tanenbaum LN,
    2. Tsiouris AJ,
    3. Johnson AN, et al
    . Synthetic MRI for clinical neuroimaging: results of the Magnetic Resonance Image Compilation (MAGiC) prospective, multicenter, multireader trial. AJNR Am J Neuroradiol 2017;38:1103–10 doi:10.3174/ajnr.A5227 pmid:28450439
    Abstract/FREE Full Text
  19. 19.↵
    1. Kerleroux B,
    2. Kober T,
    3. Hilbert T, et al
    . Clinical equivalence assessment of T2 synthesized pediatric brain magnetic resonance imaging. J Neuroradiol 2019;46:130–35 doi:10.1016/j.neurad.2018.04.003 pmid:29733917
    CrossRefPubMed
  20. 20.↵
    1. Said SM,
    2. Yeh TL,
    3. Greenwood RS, et al
    . MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis. Neuroreport 1996;7:1941–44 doi:10.1097/00001756-199608120-00015 pmid:8905698
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. West J,
    2. Aalto A,
    3. Tisell A, et al
    . Normal appearing and diffusely abnormal white matter in patients with multiple sclerosis assessed with quantitative MR. PLoS One 2014;9:e95161 doi:10.1371/journal.pone.0095161 pmid:24747946
    CrossRefPubMed
  22. 22.↵
    1. Saccenti L,
    2. Hagiwara A,
    3. Andica C, et al
    . Myelin measurement using quantitative magnetic resonance imaging: a correlation study comparing various imaging techniques in patients with multiple sclerosis. Cells 2020;9:393 doi:10.3390/cells9020393 pmid:32046340
    CrossRefPubMed
  23. 23.↵
    1. Tognini G,
    2. Ferrozzi F,
    3. Garlaschi G, et al
    . Brain apparent diffusion coefficient evaluation in pediatric patients with neurofibromatosis type 1. J Comput Assist Tomogr 2005;29:298–304 doi:10.1097/01.rct.0000162406.71300.b7 pmid:15891494
    CrossRefPubMed
  24. 24.↵
    1. Zamboni SL,
    2. Loenneker T,
    3. Boltshauser E, et al
    . Contribution of diffusion tensor MR imaging in detecting cerebral microstructural changes in adults with neurofibromatosis type 1. AJNR Am J Neuroradiol 2007;1:773 pmid:17416837
    PubMed
  25. 25.↵
    1. Wang L,
    2. Goldstein FC,
    3. Veledar E, et al
    . Alterations in cortical thickness and white matter integrity in mild cognitive impairment measured by whole-brain cortical thickness mapping and diffusion tensor imaging. AJNR Am J Neuroradiol 2009;30:893–99 doi:10.3174/ajnr.A1484 pmid:19279272
    Abstract/FREE Full Text
  26. 26.↵
    1. Karlsgodt KH,
    2. Rosser T,
    3. Lutkenhoff ES, et al
    . Alterations in white matter microstructure in neurofibromatosis-1. PLoS One 2012;7:e47854 doi:10.1371/journal.pone.0047854 pmid:23094098
    CrossRefPubMed
  27. 27.↵
    1. Song SK,
    2. Sun SW,
    3. Ramsbottom MJ, et al
    . Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage 2002;17:1429–36 doi:10.1006/nimg.2002.1267 pmid:12414282
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Wilkinson ID,
    2. Griffiths PD,
    3. Wales JK
    . Proton magnetic resonance spectroscopy of brain lesions in children with neurofibromatosis type 1. Magn Reson Imaging 2001;19:1081–89 doi:10.1016/S0730-725X(01)00446-5 pmid:11711232
    CrossRefPubMed
  29. 29.↵
    1. Jones AP,
    2. Gunawardena WJ,
    3. Coutinho CM
    . 1H MR spectroscopy evidence for the varied nature of asymptomatic focal brain lesions in neurofibromatosis type 1. Neuroradiology 2001;43:62–67 doi:10.1007/s002340000388 pmid:11214651
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Ferraz-Filho JR,
    2. da Rocha AJ,
    3. Muniz MP, et al
    . Diffusion tensor MR imaging in neurofibromatosis type 1: expanding the knowledge of microstructural brain abnormalities. Pediatr Radiol 2012;42:449–54 doi:10.1007/s00247-011-2274-1 pmid:22033857
    CrossRefPubMed
  31. 31.↵
    1. van Engelen SJ,
    2. Krab LC,
    3. Moll HA, et al
    . Quantitative differentiation between healthy and disordered brain matter in patients with neurofibromatosis type I using diffusion tensor imaging. AJNR Am J Neuroradiol 2008;29:816–22 doi:10.3174/ajnr.A0921 pmid:18339726
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 42 (9)
American Journal of Neuroradiology
Vol. 42, Issue 9
1 Sep 2021
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Synthetic MRI in Neurofibromatosis Type 1
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
G. Coban, S. Parlak, E. Gumeler, H. Altunbuker, B. Konuşkan, J. Karakaya, B. Anlar, K.K. Oguz
Synthetic MRI in Neurofibromatosis Type 1
American Journal of Neuroradiology Sep 2021, 42 (9) 1709-1715; DOI: 10.3174/ajnr.A7214

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Synthetic MRI in Neurofibromatosis Type 1
G. Coban, S. Parlak, E. Gumeler, H. Altunbuker, B. Konuşkan, J. Karakaya, B. Anlar, K.K. Oguz
American Journal of Neuroradiology Sep 2021, 42 (9) 1709-1715; DOI: 10.3174/ajnr.A7214
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • ACKNOWLEDGMENT
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref (2)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status
    Chris W J van der Weijden, Emma Biondetti, Ingomar W Gutmann, Hildebrand Dijkstra, Rory McKerchar, Daniele de Paula Faria, Erik F J de Vries, Jan F Meilof, Rudi A J O Dierckx, Valentin H Prevost, Alexander Rauscher
    Brain 2023 146 4
  • Synthetic MRI in children with tuberous sclerosis complex
    Gokcen Coban, Ekim Gumeler, Safak Parlak, Bahadir Konuskan, Jale Karakaya, Dilek Yalnizoglu, Banu Anlar, Kader K. Oguz
    Insights into Imaging 2022 13 1

More in this TOC Section

  • SyMRI & MR Fingerprinting in Brainstem Myelination
  • Comparison of Image Quality and Radiation Dose in Pediatric Temporal Bone CT Using Photon-Counting Detector CT and Energy-Integrating Detector CT
  • Axenfeld-Rieger Syndrome: Neuroimaging Findings
Show more Pediatrics

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire