Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatrics

When Should a Brain MRI Be Performed in Children with New-Onset Seizures? Results of a Large Prospective Trial

R. Hourani, W. Nasreddine, M. Dirani, G. Hmaimess, S. Sabbagh, O. El Tourjuman, J. Wazne, H. Toufaili, N. AlArab, M. El Dassouki and A. Beydoun
American Journal of Neuroradiology September 2021, 42 (9) 1695-1701; DOI: https://doi.org/10.3174/ajnr.A7193
R. Hourani
aFrom the Departments of Radiology (R.H., N.A.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Hourani
W. Nasreddine
bNeurology (W.N., M.D., A.B.), American University of Beirut Medical Center, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for W. Nasreddine
M. Dirani
bNeurology (W.N., M.D., A.B.), American University of Beirut Medical Center, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Dirani
G. Hmaimess
cDepartment of Pediatrics (G.H.), St George Hospital Medical University Center, University of Balamand, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Hmaimess
S. Sabbagh
dDepartment of Pediatrics (S.S.), Hotel Dieu de France Hospital, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Sabbagh
O. El Tourjuman
eDepartment of Neurology (O.E.T., J.W., M.E.D.), Rafic Hariri University Hospital, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for O. El Tourjuman
J. Wazne
eDepartment of Neurology (O.E.T., J.W., M.E.D.), Rafic Hariri University Hospital, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Wazne
H. Toufaili
fLabib Medical Center (H.T.), Beirut, Lebanon.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for H. Toufaili
N. AlArab
aFrom the Departments of Radiology (R.H., N.A.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N. AlArab
M. El Dassouki
eDepartment of Neurology (O.E.T., J.W., M.E.D.), Rafic Hariri University Hospital, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. El Dassouki
A. Beydoun
bNeurology (W.N., M.D., A.B.), American University of Beirut Medical Center, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Beydoun
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • FIG 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG 1.

    Frequencies of epileptogenic lesions stratified by etiologic categories.

  • FIG 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG 2.

    Percentages of children with epileptogenic lesions stratified according to seizure types and the presence or absence of developmental delay. GTC indicates generalized tonic-clonic seizures.

  • FIG 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG 3.

    Recursive partition analysis stratified children into 4 groups based only on the presence of DD and seizure types. GTC indicates generalized tonic-clonic seizures.

Tables

  • Figures
    • View popup
    Table 1:

    Demographic variables of the 1000 children included in the study

    Demographics
    Age
     Mean7.8 yr
     Range6 mo to 17.9 yr
    Sex
     Male/female581/419
    No. of seizures (%)
     1 seizure315 (31.5%)
     Multiple seizures685 (68.5%)
    Seizure type (No.) (%)
     Focal-onset seizures484 (48.4%)
     Unknown-onset tonic-clonic seizures260 (26.0%)
     Absence and/or myoclonus with or  without generalized tonic-clonic seizures130 (13.0%)
     Spasms, tonic or atonic seizures93 (9.3%)
     Unclassified33 (3.3%)
    Psychomotor development (No.) (%)
     Normal777 (77.7%)
     Delay223 (22.3%)
     Mild DD70 (7.0%)
     Moderate DD63 (6.3%)
     Severe/profound DD90 (9.0%)
    • View popup
    Table 2:

    Frequencies of epileptogenic lesion subtypes stratified by age groupsa

    0–2 Years (n = 169)2–5 Years (n = 189)5–10 Years (n = 281)10–15 Years (n = 257)15–18 Years (n = 104)
    Epileptogenic lesions82 (48.5%)57 (30.2%)60 (21.4%)47 (18.3%)14 (13.5%)
    MCD22 (26.8%)20 (35.1%)24 (40.0%)18 (38.3%)0 (0.0%)
    Hypoxic-ischemic26 (31.7%)14 (24.6%)9 (15.0%)2 (4.3%)0 (0.0%)
    Vascular14 (17.1%)10 (17.5%)6 (10.0%)9 (19.1%)3 (21.4%)
    MTS2 (2.4%)1 (1.8%)5 (8.3%)9 (19.1%)3 (21.4%)
    NCS8 (9.8%)1 (1.8%)4 (6.7%)1 (2.1%)1 (7.1%)
    Tumoral0 (0.0%)3 (5.3%)4 (6.7%)4 (8.5%)4 (28.6%)
    Other10 (12.2%)8 (14.0%)8 (13.3%)4 (8.5%)3 (21.4%)
    • ↵a 95% CI for the percentages of epileptogenic lesions in the 0–2 year, 2–5 year, 5–10 year, 10–15 year, and 15–18 year age groups were 41.1%–56.0%, 24.1%–37%, 17.0%–26.5%, 14.0%–23.5%, and 8.2%–21.3%, respectively.

    • View popup
    Table 3:

    Frequencies of epileptogenic lesions stratified by seizure type at presentation

    Seizure TypesEpileptogenic Lesions
    Absence and/or myoclonus with or without generalized tonic-clonic seizures (n = 130)8 (6.2%)
    Unknown-onset tonic-clonic seizures (n = 260)38 (14.6%)
    Unclassified (n = 33)5 (15.2%)
    Focal-onset seizures (n = 484)148 (30.6%)
    Spasms, tonic or atonic seizures (n = 93)61 (65.6%)
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 42 (9)
American Journal of Neuroradiology
Vol. 42, Issue 9
1 Sep 2021
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
When Should a Brain MRI Be Performed in Children with New-Onset Seizures? Results of a Large Prospective Trial
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
R. Hourani, W. Nasreddine, M. Dirani, G. Hmaimess, S. Sabbagh, O. El Tourjuman, J. Wazne, H. Toufaili, N. AlArab, M. El Dassouki, A. Beydoun
When Should a Brain MRI Be Performed in Children with New-Onset Seizures? Results of a Large Prospective Trial
American Journal of Neuroradiology Sep 2021, 42 (9) 1695-1701; DOI: 10.3174/ajnr.A7193

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
When Should a Brain MRI Be Performed in Children with New-Onset Seizures? Results of a Large Prospective Trial
R. Hourani, W. Nasreddine, M. Dirani, G. Hmaimess, S. Sabbagh, O. El Tourjuman, J. Wazne, H. Toufaili, N. AlArab, M. El Dassouki, A. Beydoun
American Journal of Neuroradiology Sep 2021, 42 (9) 1695-1701; DOI: 10.3174/ajnr.A7193
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Utility of Gadolinium-Based Contrast in Initial Evaluation of Seizures in Children Presenting Emergently
  • Crossref (7)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • A tale of two cohorts: Differing outcomes in infantile‐onset focal epilepsy
    Erin M. Triplet, Katherine Nickels, Lily Wong‐Kisiel, Anthony Fine, Elaine C. Wirrell
    Epilepsia 2022 63 4
  • Risk of recurrence in patients with an unprovoked tonic–clonic seizure and generalized epileptiform discharges on EEG
    Najo Jomaa, Wassim Nasreddine, Ghassan Hmeimess, Shawkat Beaini, Ayman Beydoun, Mostafa Hotait, Jaafar Wazne, Ahmad Beydoun
    Epilepsia 2023 64 8
  • Predictors of drug‐resistant epilepsy in childhood epilepsy syndromes: A subgroup analysis from a prospective cohort study
    Dana Ayoub, Fatima Jaafar, Amal Al‐Hajje, Pascale Salameh, Jeremy Jost, Ghassan Hmaimess, Jaafar Wazne, Zein Ismail‐Fawaz, Sandra Sabbagh, Farid Boumediene, Ahmad Beydoun
    Epilepsia 2024 65 10
  • Early predictors of remission in children and adolescents with new-onset epilepsy: A prospective study
    Dana Ayoub, Amal Al-Hajje, Pascale Salameh, Jeremy Jost, Ghassan Hmaimess, Wassim Nasreddine, Fatima Jaafar, Jaafar Wazne, Ribal Bitar, Sandra Sabbagh, Farid Boumediene, Ahmad Beydoun
    Seizure: European Journal of Epilepsy 2023 110
  • Utility of Gadolinium-Based Contrast in Initial Evaluation of Seizures in Children Presenting Emergently
    Denas Andrijauskis, Graham Woolf, Alexander Kuehne, Khalid Al-Dasuqi, Cicero T. Silva, Seyedmehdi Payabvash, Ajay Malhotra
    American Journal of Neuroradiology 2023 44 10
  • Beyond Seizures: Psychiatric comorbidities in children with epilepsy
    Dana Ayoub, Amal Al-Hajje, Pascale Salameh, Jeremy Jost, Ghassan Hmaimess, Fatima Jaafar, Tarek Halabi, Farid Boumediene, Ahmad Beydoun
    Epilepsy & Behavior 2025 163
  • Erster epileptischer Anfall bei Kindern: Bildgebung empfehlenswert?
    Neuroradiologie Scan 2022 12 02

More in this TOC Section

  • SyMRI & MR Fingerprinting in Brainstem Myelination
  • Comparison of Image Quality and Radiation Dose in Pediatric Temporal Bone CT Using Photon-Counting Detector CT and Energy-Integrating Detector CT
  • Axenfeld-Rieger Syndrome: Neuroimaging Findings
Show more Pediatrics

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire