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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

MTT and Blood-Brain Barrier Disruption within Asymptomatic Vascular WM Lesions

B.E. Dewey, X. Xu, L. Knutsson, A. Jog, J.L. Prince, P.B. Barker, P.C.M. van Zijl, R. Leigh and P. Nyquist
American Journal of Neuroradiology August 2021, 42 (8) 1396-1402; DOI: https://doi.org/10.3174/ajnr.A7165
B.E. Dewey
aFrom the Department of Electrical and Computer Engineering (B.E.D., J.L.P.), Johns Hopkins University, Baltimore, Maryland
bF.M. Kirby Research Center for Functional Brain Imaging (B.E.D., X.X., P.B.B., P.C.M.v.Z.), Kennedy Krieger Institute, Baltimore, Maryland
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X. Xu
bF.M. Kirby Research Center for Functional Brain Imaging (B.E.D., X.X., P.B.B., P.C.M.v.Z.), Kennedy Krieger Institute, Baltimore, Maryland
cDepartment of Radiology and Radiological Science (X.X., L.K., J.L.P., P.B.B., P.C.M.v.Z.), Division of MRI Research, Johns Hopkins University, Baltimore, Maryland
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L. Knutsson
cDepartment of Radiology and Radiological Science (X.X., L.K., J.L.P., P.B.B., P.C.M.v.Z.), Division of MRI Research, Johns Hopkins University, Baltimore, Maryland
dDepartment of Medical Radiation Physics (L.K.), Lund University, Lund, Sweden
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A. Jog
eAthinoula A. Martinos Center for Biomedical Imaging (A.J.), Harvard University Medical School, Boston Massachusetts
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J.L. Prince
aFrom the Department of Electrical and Computer Engineering (B.E.D., J.L.P.), Johns Hopkins University, Baltimore, Maryland
cDepartment of Radiology and Radiological Science (X.X., L.K., J.L.P., P.B.B., P.C.M.v.Z.), Division of MRI Research, Johns Hopkins University, Baltimore, Maryland
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P.B. Barker
bF.M. Kirby Research Center for Functional Brain Imaging (B.E.D., X.X., P.B.B., P.C.M.v.Z.), Kennedy Krieger Institute, Baltimore, Maryland
cDepartment of Radiology and Radiological Science (X.X., L.K., J.L.P., P.B.B., P.C.M.v.Z.), Division of MRI Research, Johns Hopkins University, Baltimore, Maryland
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P.C.M. van Zijl
bF.M. Kirby Research Center for Functional Brain Imaging (B.E.D., X.X., P.B.B., P.C.M.v.Z.), Kennedy Krieger Institute, Baltimore, Maryland
cDepartment of Radiology and Radiological Science (X.X., L.K., J.L.P., P.B.B., P.C.M.v.Z.), Division of MRI Research, Johns Hopkins University, Baltimore, Maryland
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R. Leigh
fDepartment of Neurology (R.L., P.N.), Electrical and Computer Engineering (B.E.D., J.L.P.), Johns Hopkins University, Baltimore, Maryland
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P. Nyquist
fDepartment of Neurology (R.L., P.N.), Electrical and Computer Engineering (B.E.D., J.L.P.), Johns Hopkins University, Baltimore, Maryland
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Article Information

vol. 42 no. 8 1396-1402
DOI 
https://doi.org/10.3174/ajnr.A7165
PubMed 
34083262

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received October 16, 2020
  • Accepted after revision March 13, 2021
  • Published online August 11, 2021.

Article Versions

  • Latest version (June 3, 2021 - 06:49).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2021 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. B.E. Deweya,b,
  2. X. Xub,c,
  3. L. Knutssonc,d,
  4. A. Joge,
  5. J.L. Princea,c,
  6. P.B. Barkerb,c,
  7. P.C.M. van Zijlb,c,
  8. R. Leighf and
  9. P. Nyquistf
  1. aFrom the Department of Electrical and Computer Engineering (B.E.D., J.L.P.), Johns Hopkins University, Baltimore, Maryland
  2. bF.M. Kirby Research Center for Functional Brain Imaging (B.E.D., X.X., P.B.B., P.C.M.v.Z.), Kennedy Krieger Institute, Baltimore, Maryland
  3. cDepartment of Radiology and Radiological Science (X.X., L.K., J.L.P., P.B.B., P.C.M.v.Z.), Division of MRI Research, Johns Hopkins University, Baltimore, Maryland
  4. dDepartment of Medical Radiation Physics (L.K.), Lund University, Lund, Sweden
  5. eAthinoula A. Martinos Center for Biomedical Imaging (A.J.), Harvard University Medical School, Boston Massachusetts
  6. fDepartment of Neurology (R.L., P.N.), Electrical and Computer Engineering (B.E.D., J.L.P.), Johns Hopkins University, Baltimore, Maryland
  1. Please address correspondence to Paul Nyquist, MD, Johns Hopkins, Department of Neurology, 416 Phipps, 600 N Wolfe St, Baltimore MD 21287; e-mail: pnyquis1{at}jhmi.edu
View Full Text

Funding

  • Stimulating and Advancing ACCM Research

  • NIH/NINDS

    RO1NS062059-01

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B.E. Dewey, X. Xu, L. Knutsson, A. Jog, J.L. Prince, P.B. Barker, P.C.M. van Zijl, R. Leigh, P. Nyquist
MTT and Blood-Brain Barrier Disruption within Asymptomatic Vascular WM Lesions
American Journal of Neuroradiology Aug 2021, 42 (8) 1396-1402; DOI: 10.3174/ajnr.A7165

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MTT and Blood-Brain Barrier Disruption within Asymptomatic Vascular WM Lesions
B.E. Dewey, X. Xu, L. Knutsson, A. Jog, J.L. Prince, P.B. Barker, P.C.M. van Zijl, R. Leigh, P. Nyquist
American Journal of Neuroradiology Aug 2021, 42 (8) 1396-1402; DOI: 10.3174/ajnr.A7165
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Microvascular Dysfunction in Blood-Brain Barrier Disruption and Hypoperfusion Within the Infarct Posttreatment Are Associated With Cerebral Edema
    Felix C. Ng, Leonid Churilov, Nawaf Yassi, Timothy J. Kleinig, Vincent Thijs, Teddy Y. Wu, Darshan G. Shah, Helen M. Dewey, Gargan Sharma, Patricia M. Desmond, Bernard Yan, Mark W. Parsons, Geoffrey A. Donnan, Stephen M. Davis, Peter J. Mitchell, Richard Leigh, Bruce C.V. Campbell
    Stroke 2022 53 5
  • How can imaging in acute ischemic stroke help us to understand tissue fate in the era of endovascular treatment and cerebroprotection?
    Mayank Goyal, Ryan McTaggart, Johanna M. Ospel, Aad van der Lugt, Michael Tymianski, Roland Wiest, Johan Lundberg, Rüdiger von Kummer, Michael D. Hill, Sven Luijten, Bob Roozenbeek, Jeffrey L. Saver, Rosalie V. McDonough
    Neuroradiology 2022 64 9
  • Blood–Brain Barrier Dysfunction and the Potential Mechanisms in Chronic Cerebral Hypoperfusion Induced Cognitive Impairment
    WenQing Xu, Qingke Bai, Qiang Dong, Min Guo, Mei Cui
    Frontiers in Cellular Neuroscience 2022 16
  • Abnormal cerebral hemodynamics and blood-brain barrier permeability detected with perfusion MRI in systemic lupus erythematosus patients
    T. Salomonsson, T. Rumetshofer, A. Jönsen, A.A. Bengtsson, K.A. Zervides, P. Nilsson, M. Knutsson, R. Wirestam, J. Lätt, L. Knutsson, P.C. Sundgren
    NeuroImage: Clinical 2023 38
  • Evidence of Neurovascular Water Exchange and Endothelial Vascular Dysfunction in Schizophrenia: An Exploratory Study
    Eric L Goldwaser, Danny J J Wang, Bhim M Adhikari, Joshua Chiappelli, Xingfeng Shao, Jiaao Yu, Tong Lu, Shuo Chen, Wyatt Marshall, Alexa Yuen, Mark Kvarta, Yizhou Ma, Xiaoming Du, Si Gao, Osamah Saeedi, Heather Bruce, Patrick Donnelly, Hugh O’Neill, Alan R Shuldiner, Braxton D Mitchell, Peter Kochunov, L Elliot Hong
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    Magnetic Resonance Imaging 2023 102
  • Blood-brain barrier breakdown in brain ischemia: Insights from MRI perfusion imaging
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