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Research ArticlePediatrics

Transient Hyperintensity of the Infant Thyroid Gland on T1-Weighted MR Imaging: Correlation with Postnatal Age, Gestational Age, and Signal Intensity of the Pituitary Gland

H. Maki, M. Nakagawa, R. Kagaya, S. Kumazawa, K. Matsumoto, M. Hatano, Y. Miyake, W. Sugihara and Y. Shibamoto
American Journal of Neuroradiology May 2021, 42 (5) 955-960; DOI: https://doi.org/10.3174/ajnr.A7024
H. Maki
aDepartment of Radiology (H.M., M.N., S.K., K.M., W.S., Y.S.), Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Aichi, Japan
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M. Nakagawa
aDepartment of Radiology (H.M., M.N., S.K., K.M., W.S., Y.S.), Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Aichi, Japan
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R. Kagaya
bDepartment of Radiology, Kariya Toyota General Hospital (R.K.), Kariya-shi, Aichi, Japan
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S. Kumazawa
aDepartment of Radiology (H.M., M.N., S.K., K.M., W.S., Y.S.), Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Aichi, Japan
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K. Matsumoto
aDepartment of Radiology (H.M., M.N., S.K., K.M., W.S., Y.S.), Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Aichi, Japan
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M. Hatano
cDepartment of Radiology, Nagoya City West Medical Center (M.H.), Nagoya, Japan
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Y. Miyake
dDepartment of Radiology (Y.M.), Nagoya Daini Red Cross Hospital, Nagoya-shi, Aichi, Japan
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W. Sugihara
aDepartment of Radiology (H.M., M.N., S.K., K.M., W.S., Y.S.), Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Aichi, Japan
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Y. Shibamoto
aDepartment of Radiology (H.M., M.N., S.K., K.M., W.S., Y.S.), Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Aichi, Japan
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  • FIG 1.
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    FIG 1.

    Axial 3D GRE T1-weighted MR images of an infant at postnatal day 6 show the thyroid (A) and pituitary (B). For measurement of the signal intensity, ROIs are placed on the thyroid (black circle, A), sternocleidomastoid muscle (white circle, A), and anterior pituitary (black circle, B). The posterior pituitary is shown (arrow, B).

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    FIG 2.

    Scatterplots of the thyroid–muscle signal intensity ratio against the corresponding postnatal age at examination (A) and gestational age at examination (B). There is a negative correlation between the thyroid–muscle signal intensity ratio and postnatal age at examination (A). Conversely, there is no distinct relationship between the thyroid–muscle signal intensity ratio and gestational age at examination (B).

  • FIG 3.
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    FIG 3.

    Five different cases showing the thyroid (arrowheads) and anterior pituitary (arrows) on coronal 3D GRE T1-weighted MR images examined at different postnatal ages: 4 days (A), 21 days (B), 33 days (C), 46 days (D), and 70 days (E). These patients' gestational ages at birth are 41, 34, 31, 31, and 29 weeks, respectively. At 4 days of postnatal age, the thyroid and anterior pituitary show extremely high signal intensity (A), and the signal intensity of those glands decreased proportionally to postnatal age (B–E). The signal intensities of the thyroid glands are similar to those of the anterior pituitary glands regardless of postnatal age, and the thyroid–anterior pituitary signal intensity ratios are almost 1 (A = 0.91, B = 1.04, C = 0.83, D = 0.81, E = 0.92).

Tables

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  • Means of thyroid–muscle, anterior pituitary–muscle, and thyroid–anterior pituitary signal intensity ratios against the corresponding postnatal age at examination grouped according to week

    Postnatal Age at ExaminationSignal Intensity Ratio
    Thyroid–MuscleAnterior Pituitary–MuscleThyroid–Anterior Pituitary
    DayNoMean (SD)Mean (SD)Mean (SD)
    0–6202.03 (0.15)2.01 (0.30)1.03 (0.16)
    7–13221.99 (0.13)2.00 (0.23)1.01 (0.12)
    14–20261.88 (0.19)1.78 (0.29)1.07 (0.13)
    21–27311.67 (0.25)1.65 (0.17)1.02 (0.14)
    28–34201.54 (0.19)1.50 (0.19)1.03 (0.11)
    35–4191.57 (0.18)1.60 (0.27)1.00 (0.17)
    42–48121.38 (0.17)1.43 (0.20)0.98 (0.11)
    49–55131.34 (0.17)1.36 (0.21)1.00 (0.14)
    56–62101.40 (0.22)1.36 (0.18)1.03 (0.12)
    63–6921.25 (0.02)1.26 (0.18)1.02 (0.17)
    70–7651.19 (0.10)1.16 (0.10)1.03 (0.10)
    77–8331.13 (0.04)1.06 (0.02)1.06 (0.06)
    84–9041.16 (0.05)1.12 (0.04)1.03 (0.06)
    91–9721.10 (0.20)1.13 (0.03)0.97 (0.15)
    98–10421.09 (0.08)1.14 (0.12)0.96 (0.03)
    105–11121.10 (0.01)1.14 (0.11)0.97 (0.10)
    Total183
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American Journal of Neuroradiology: 42 (5)
American Journal of Neuroradiology
Vol. 42, Issue 5
1 May 2021
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H. Maki, M. Nakagawa, R. Kagaya, S. Kumazawa, K. Matsumoto, M. Hatano, Y. Miyake, W. Sugihara, Y. Shibamoto
Transient Hyperintensity of the Infant Thyroid Gland on T1-Weighted MR Imaging: Correlation with Postnatal Age, Gestational Age, and Signal Intensity of the Pituitary Gland
American Journal of Neuroradiology May 2021, 42 (5) 955-960; DOI: 10.3174/ajnr.A7024

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Transient Hyperintensity of the Infant Thyroid Gland on T1-Weighted MR Imaging: Correlation with Postnatal Age, Gestational Age, and Signal Intensity of the Pituitary Gland
H. Maki, M. Nakagawa, R. Kagaya, S. Kumazawa, K. Matsumoto, M. Hatano, Y. Miyake, W. Sugihara, Y. Shibamoto
American Journal of Neuroradiology May 2021, 42 (5) 955-960; DOI: 10.3174/ajnr.A7024
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