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Research ArticlePediatrics

Pediatric Head CT: Automated Quantitative Analysis with Quantile Regression

K.A. Cauley, Y. Hu and S.W. Fielden
American Journal of Neuroradiology February 2021, 42 (2) 382-388; DOI: https://doi.org/10.3174/ajnr.A6885
K.A. Cauley
aFrom the Departments of Radiology (K.A.C.)
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Y. Hu
bBiomedical and Translational Informatics (Y.H.), Geisinger Medical Center, Danville, Pennsylvania
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S.W. Fielden
cGeisinger Autism and Developmental Medicine Institute (S.W.F.), Lewisburg, Pennsylvania
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  • FIG 1.
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    FIG 1.

    Products of automated head CT segmentation. Routine clinical head CT (A), brain-extracted image (B), and CSF eliminated (brain parenchyma) (C).

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    FIG 2.

    Scatterplots of computed brain metrics as a function of subject age: brain volume (A), BPF (B), mean brain radiodensity (C), and brain radiomass (D).

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    FIG 3.

    Box-and-whisker plots of BPF: 0–3 years (left) and 5–20 years (right). Tabular data below 0–3 years (Table 1). Data scatter is greater immediately after birth and decreases during the first 2 years, and the pattern is similar between the sexes. There is no significant difference between the mean BPF of the groupings. Table 2 shows statistically significant difference between the means of 5-year groupings.

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    FIG 4.

    Quantile regression of brain volume (upper graphs) and BPF (lower graphs), male on the left, female on the right. The 5%–95% and 10%–90% quantiles are shown.

Tables

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    Table 1:

    Brain parenchymal fraction 0–3.0 years

    MaleFemale
    Age (yr)TotalMeanSDTotalMeanSD
    0–0.5200.8450.047170.840.062
    0.5–1.0150.860.018230.860.035
    1.0–1.5120.870.022130.870.024
    1.5–2.0100.860.03070.870.033
    2.0–2.540.870.00520.890.014
    2.5–3.020.890.00040.880.014
    • View popup
    Table 2:

    Brain parenchymal fraction 5–20 years

    Age (yr)TotalMean5–10 Years (P Value)10–15 Years (P Value)
    Male
     5–10180.872
     10–15200.879NS
     15–20720.891<.001.004
    Female
     5–10120.874
     10–15200.877NS
     15–20700.889.003.003
    • Note:—NS indicates not significant.

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American Journal of Neuroradiology: 42 (2)
American Journal of Neuroradiology
Vol. 42, Issue 2
1 Feb 2021
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K.A. Cauley, Y. Hu, S.W. Fielden
Pediatric Head CT: Automated Quantitative Analysis with Quantile Regression
American Journal of Neuroradiology Feb 2021, 42 (2) 382-388; DOI: 10.3174/ajnr.A6885

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Pediatric Head CT: Automated Quantitative Analysis with Quantile Regression
K.A. Cauley, Y. Hu, S.W. Fielden
American Journal of Neuroradiology Feb 2021, 42 (2) 382-388; DOI: 10.3174/ajnr.A6885
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