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Neurite orientation dispersion and density imaging (NODDI) assesses microstructural features of neurites contributing to diffusion imaging signals. Twenty-one subjects with MS underwent serial enhanced MRIs including NODDI, the key metrics of which are the neurite density and orientation dispersion index. Twenty-one age- and sex-matched healthy controls underwent unenhanced MR imaging with the same protocol. NODDI is a promising tool with the potential to detect acute MS inflammation. The observed heterogeneity among lesions may correspond to gradients in severity and clinical recovery after the acute phase.

In a retrospective multicenter study, all patients treated with the FRED for a ruptured intracranial blister-like aneurysm between January 2013 and May 2019 were analyzed. In total, 30 patients with 30 ruptured blister-like aneurysms were treated. Immediate complete aneurysm obliteration with the FRED was achieved in 10 patients (33%). Of the 26 patients with follow-up, complete obliteration was achieved in 21 patients (80%) after 6 months and in 24 patients (92%) in the final follow-up (median, 22 months). The authors conclude that treatment of ruptured blister-like aneurysms with the FRED is safe and effective.