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Research ArticlePediatrics

Brain and CSF Volumes in Fetuses and Neonates with Antenatal Diagnosis of Critical Congenital Heart Disease: A Longitudinal MRI Study

N.H.P. Claessens, N. Khalili, I. Isgum, H. ter Heide, T.J. Steenhuis, E. Turk, N.J.G. Jansen, L.S. de Vries, J.M.P.J. Breur, R. de Heus and M.J.N.L. Benders
American Journal of Neuroradiology May 2019, 40 (5) 885-891; DOI: https://doi.org/10.3174/ajnr.A6021
N.H.P. Claessens
aFrom the Departments of Neonatology (N.H.P.C., E.T., L.S.d.V., M.J.N.L.B.)
bPediatric Cardiology (N.H.P.C., H.t.H., T.J.S., J.M.P.J.B.)
cPediatric Intensive Care (N.H.P.C., N.J.G.J.)
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N. Khalili
eImage Sciences Institute (N.K., I.I.), University Medical Center Utrecht, Utrecht, the Netherlands
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I. Isgum
eImage Sciences Institute (N.K., I.I.), University Medical Center Utrecht, Utrecht, the Netherlands
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H. ter Heide
bPediatric Cardiology (N.H.P.C., H.t.H., T.J.S., J.M.P.J.B.)
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T.J. Steenhuis
bPediatric Cardiology (N.H.P.C., H.t.H., T.J.S., J.M.P.J.B.)
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E. Turk
aFrom the Departments of Neonatology (N.H.P.C., E.T., L.S.d.V., M.J.N.L.B.)
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N.J.G. Jansen
cPediatric Intensive Care (N.H.P.C., N.J.G.J.)
fDepartment of Pediatrics (N.J.G.J.), Beatrix Children's Hospital, University Medical Center Groningen, Groningen, the Netherlands.
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L.S. de Vries
aFrom the Departments of Neonatology (N.H.P.C., E.T., L.S.d.V., M.J.N.L.B.)
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J.M.P.J. Breur
bPediatric Cardiology (N.H.P.C., H.t.H., T.J.S., J.M.P.J.B.)
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R. de Heus
dObstetrics (R.d.H.), Wilhelmina Children's Hospital, Utrecht, the Netherlands
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M.J.N.L. Benders
aFrom the Departments of Neonatology (N.H.P.C., E.T., L.S.d.V., M.J.N.L.B.)
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REFERENCES

  1. 1.↵
    1. Claessens NH,
    2. Kelly CJ,
    3. Counsell SJ, et al
    . Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease. Dev Med Child Neurol 2017;59:894–902 doi:10.1111/dmcn.13461 pmid:28542743
    CrossRefPubMed
  2. 2.↵
    1. Peyvandi S,
    2. Chau V,
    3. Guo T, et al
    . Neonatal brain injury and timing of neurodevelopmental assessment in patients with congenital heart disease. J Am Coll Cardiol 2018;71:1986–96 doi:10.1016/j.jacc.2018.02.068 pmid:29724352
    FREE Full Text
  3. 3.↵
    1. Claessens NH,
    2. Algra SO,
    3. Ouwehand TL, et al
    ; CHD Lifespan Study Group Utrecht. Perioperative neonatal brain injury is associated with worse school-age neurodevelopment in children with critical congenital heart disease. Dev Med Child Neurol 2018;60:1052–58 doi:10.1111/dmcn.13747 pmid:29572821
    CrossRefPubMed
  4. 4.↵
    1. von Rhein M,
    2. Buchmann A,
    3. Hagmann C, et al
    ; Heart and Brain Research Group. Severe congenital heart defects are associated with global reduction of neonatal brain volumes. J Pediatr 2015;167:1259–63 e1 doi:10.1016/j.jpeds.2015.07.006 pmid:26233604
    CrossRefPubMed
  5. 5.↵
    1. Kelly CJ,
    2. Makropoulos A,
    3. Cordero-Grande L, et al
    . Impaired development of the cerebral cortex in infants with congenital heart disease is correlated to reduced cerebral oxygen delivery. Sci Rep 2017;7:15088 doi:10.1038/s41598-017-14939-z pmid:29118365
    CrossRefPubMed
  6. 6.↵
    1. Limperopoulos C,
    2. Tworetzky W,
    3. McElhinney DB, et al
    . Brain volume and metabolism in fetuses with congenital heart disease: evaluation with quantitative magnetic resonance imaging and spectroscopy. Circulation 2010;121:26–33 doi:10.1161/CIRCULATIONAHA.109.865568 pmid:20026783
    Abstract/FREE Full Text
  7. 7.↵
    1. Sun L,
    2. Macgowan CK,
    3. Sled JG, et al
    . Reduced fetal cerebral oxygen consumption is associated with smaller brain size in fetuses with congenital heart disease. Circulation 2015;131:1313–23 doi:10.1161/CIRCULATIONAHA.114.013051 pmid:25762062
    Abstract/FREE Full Text
  8. 8.↵
    1. Lim JM,
    2. Kingdom T,
    3. Saini B, et al
    . Cerebral oxygen delivery is reduced in newborns with congenital heart disease. J Thorac Cardiovasc Surg 2016;152:1095–103 doi:10.1016/j.jtcvs.2016.05.027 pmid:27349283
    CrossRefPubMed
  9. 9.↵
    1. Garel C,
    2. Alberti C
    . Coronal measurement of the fetal lateral ventricles: comparison between ultrasonography and magnetic resonance imaging. Ultrasound Obstet Gynecol 2006;27:23–27 pmid:16323152
    CrossRefPubMed
  10. 10.↵
    1. Papile LA,
    2. Burstein J,
    3. Burstein R, et al
    . Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978;92:529–34 doi:10.1016/S0022-3476(78)80282-0 pmid:305471
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Moeskops P,
    2. Viergever MA,
    3. Mendrik AM, et al
    . Automatic segmentation of MR brain images with a convolutional neural network. IEEE Trans Med Imaging 2016;35:1252–61 doi:10.1109/TMI.2016.2548501 pmid:27046893
    CrossRefPubMed
  12. 12.↵
    1. Kersbergen KJ,
    2. Makropoulos A,
    3. Aljabar P, et al
    . Longitudinal regional brain development and clinical risk factors in extremely preterm infants. J Pediatr 2016;178:93–100.e6 doi:10.1016/j.jpeds.2016.08.024 pmid:27634629
    CrossRefPubMed
  13. 13.↵
    1. Schellen C,
    2. Ernst S,
    3. Gruber GM, et al
    . Fetal MRI detects early alterations of brain development in tetralogy of Fallot. Am J Obstet Gynecol 2015;213:392 e1–7 doi:10.1016/j.ajog.2015.05.046 pmid:26008177
    CrossRefPubMed
  14. 14.↵
    1. Andescavage N,
    2. Yarish A,
    3. Donofrio M, et al
    . 3-D volumetric MRI evaluation of the placenta in fetuses with complex congenital heart disease. Placenta 2015;36:1024–30 doi:10.1016/j.placenta.2015.06.013 pmid:26190037
    CrossRefPubMed
  15. 15.↵
    1. Brossard-Racine M,
    2. du Plessis AJ,
    3. Vezina G, et al
    . Prevalence and spectrum of in utero structural brain abnormalities in fetuses with complex congenital heart disease. AJNR Am J Neuroradiol 2014;35:1593–99 doi:10.3174/ajnr.A3903 pmid:24651820
    Abstract/FREE Full Text
  16. 16.↵
    1. Andescavage NN,
    2. DuPlessis A,
    3. McCarter R, et al
    . Cerebrospinal fluid and parenchymal brain development and growth in the healthy fetus. Dev Neurosci 2016;38:420–29 doi:10.1159/000456711 pmid:28315866
    CrossRefPubMed
  17. 17.↵
    1. Heye KN,
    2. Knirsch W,
    3. Latal B, et al
    . Reduction of brain volumes after neonatal cardiopulmonary bypass surgery in single-ventricle congenital heart disease before fontan completion. Pediatr Res 2018;83:63–70 doi:10.1038/pr.2017.203 pmid:29278641
    CrossRefPubMed
  18. 18.↵
    1. Claessens NH,
    2. Moeskops P,
    3. Buchmann A, et al
    . Delayed cortical gray matter development in neonates with severe congenital heart disease. Pediatr Res 2016;80:668–74 doi:10.1038/pr.2016.145 pmid:27434120
    CrossRefPubMed
  19. 19.↵
    1. Clouchoux C,
    2. du Plessis AJ,
    3. Bouyssi-Kobar M, et al
    . Delayed cortical development in fetuses with complex congenital heart disease. Cereb Cortex 2013;23:2932–43 doi:10.1093/cercor/bhs281 pmid:22977063
    CrossRefPubMed
  20. 20.↵
    1. Owen M,
    2. Shevell M,
    3. Donofrio M, et al
    . Brain volume and neurobehavior in newborns with complex congenital heart defects. J Pediatr 2014;164:1121–27 e1 pmid:24367983
    CrossRefPubMed
  21. 21.↵
    1. von Rhein M,
    2. Buchmann A,
    3. Hagmann C, et al
    . Brain volumes predict neurodevelopment in adolescents after surgery for congenital heart disease. Brain 2014;137:268–76 doi:10.1093/brain/awt322 pmid:24277720
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Dimitropoulos A,
    2. McQuillen PS,
    3. Sethi V, et al
    . Brain injury and development in newborns with critical congenital heart disease. Neurology 2013;81:241–48 doi:10.1212/WNL.0b013e31829bfdcf pmid:23771484
    Abstract/FREE Full Text
  23. 23.↵
    1. Andropoulos DB,
    2. Hunter JV,
    3. Nelson DP, et al
    . Brain immaturity is associated with brain injury before and after neonatal cardiac surgery with high-flow bypass and cerebral oxygenation monitoring. J Thorac Cardiovasc Surg 2010;139:543–56 doi:10.1016/j.jtcvs.2009.08.022 pmid:19909994
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Donofrio MT,
    2. Bremer YA,
    3. Schieken RM, et al
    . Autoregulation of cerebral blood flow in fetuses with congenital heart disease: the brain sparing effect. Pediatr Cardiol 2003;24:436–43 doi:10.1007/s00246-002-0404-0 pmid:14627309
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Peyvandi S,
    2. Kim H,
    3. Lau J, et al
    . The association between cardiac physiology, acquired brain injury, and postnatal brain growth in critical congenital heart disease. J Thorac Cardiovasc Surg 2018;155:291–300 e3 doi:10.1016/j.jtcvs.2017.08.019 pmid:28918207
    CrossRefPubMed
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American Journal of Neuroradiology: 40 (5)
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N.H.P. Claessens, N. Khalili, I. Isgum, H. ter Heide, T.J. Steenhuis, E. Turk, N.J.G. Jansen, L.S. de Vries, J.M.P.J. Breur, R. de Heus, M.J.N.L. Benders
Brain and CSF Volumes in Fetuses and Neonates with Antenatal Diagnosis of Critical Congenital Heart Disease: A Longitudinal MRI Study
American Journal of Neuroradiology May 2019, 40 (5) 885-891; DOI: 10.3174/ajnr.A6021

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Brain and CSF Volumes in Fetuses and Neonates with Antenatal Diagnosis of Critical Congenital Heart Disease: A Longitudinal MRI Study
N.H.P. Claessens, N. Khalili, I. Isgum, H. ter Heide, T.J. Steenhuis, E. Turk, N.J.G. Jansen, L.S. de Vries, J.M.P.J. Breur, R. de Heus, M.J.N.L. Benders
American Journal of Neuroradiology May 2019, 40 (5) 885-891; DOI: 10.3174/ajnr.A6021
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