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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Quantitative Susceptibility Mapping to Assess Cerebral Vascular Compliance

C. Birkl, C. Langkammer, P. Sati, C. Enzinger, F. Fazekas and S. Ropele
American Journal of Neuroradiology March 2019, 40 (3) 460-463; DOI: https://doi.org/10.3174/ajnr.A5933
C. Birkl
aFrom the Department of Neurology (C.B., C.L., C.E., F.F., S.R.), Medical University of Graz, Graz, Austria
bUniversity of British Columbia MRI Research Centre (C.B.), University of British Columbia, Vancouver, British Columbia, Canada
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C. Langkammer
aFrom the Department of Neurology (C.B., C.L., C.E., F.F., S.R.), Medical University of Graz, Graz, Austria
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P. Sati
cTranslational Neuroradiology Unit (P.S.), Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
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C. Enzinger
aFrom the Department of Neurology (C.B., C.L., C.E., F.F., S.R.), Medical University of Graz, Graz, Austria
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F. Fazekas
aFrom the Department of Neurology (C.B., C.L., C.E., F.F., S.R.), Medical University of Graz, Graz, Austria
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S. Ropele
aFrom the Department of Neurology (C.B., C.L., C.E., F.F., S.R.), Medical University of Graz, Graz, Austria
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    Fig 1.

    Representative T1-weighted image, quantitative susceptibility map, and the corresponding CVC map of an axial section from a single subject (from left to right). Additional axial sections of the same subject are shown in On-line Fig 4.

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    Fig 2.

    Schematic drawing of pial and subcortical blood vessels. The longest vessels with a high capability to modulate the diameter are the medullary arterioles and venules.16 According to Duvernoy type 5, these vessels follow the course of the subcortical interface over long distances before they branch into white matter.17

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    Fig 3.

    CVC map with a semicortical mask (A) and a zoomed inlay (B) showing regions with mainly arterial (arrow 1), venous (arrow 2), and pial arterial (arrow 3) contributions. In regions with predominantly arterial vessels (arrow 1), the susceptibility increases with increasing MAP (C), while it decreases in regions with predominantly venous vessels (arrow 2) with increasing MAP (D). The slope of the regression lines in C and D represents the CVC. rsq indicates the square of the correlation coefficient.

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American Journal of Neuroradiology: 40 (3)
American Journal of Neuroradiology
Vol. 40, Issue 3
1 Mar 2019
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C. Birkl, C. Langkammer, P. Sati, C. Enzinger, F. Fazekas, S. Ropele
Quantitative Susceptibility Mapping to Assess Cerebral Vascular Compliance
American Journal of Neuroradiology Mar 2019, 40 (3) 460-463; DOI: 10.3174/ajnr.A5933

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Quantitative Susceptibility Mapping to Assess Cerebral Vascular Compliance
C. Birkl, C. Langkammer, P. Sati, C. Enzinger, F. Fazekas, S. Ropele
American Journal of Neuroradiology Mar 2019, 40 (3) 460-463; DOI: 10.3174/ajnr.A5933
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