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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Disorder in Pixel-Level Edge Directions on T1WI Is Associated with the Degree of Radiation Necrosis in Primary and Metastatic Brain Tumors: Preliminary Findings

P. Prasanna, L. Rogers, T.C. Lam, M. Cohen, A. Siddalingappa, L. Wolansky, M. Pinho, A. Gupta, K.J. Hatanpaa, A. Madabhushi and P. Tiwari
American Journal of Neuroradiology March 2019, 40 (3) 412-417; DOI: https://doi.org/10.3174/ajnr.A5958
P. Prasanna
aFrom the Department of Biomedical Engineering (P.P., A.M., P.T.), Case Western Reserve University, Cleveland, Ohio
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  • ORCID record for P. Prasanna
L. Rogers
bUniversity Hospitals Case Medical Center (L.R., M.C., A.S., L.W., A.G.), Case Western Reserve School of Medicine, Cleveland, Ohio
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T.C. Lam
cTuen Mun Hospital (T.C.L.), Tuen Mun, Hong Kong
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M. Cohen
bUniversity Hospitals Case Medical Center (L.R., M.C., A.S., L.W., A.G.), Case Western Reserve School of Medicine, Cleveland, Ohio
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A. Siddalingappa
bUniversity Hospitals Case Medical Center (L.R., M.C., A.S., L.W., A.G.), Case Western Reserve School of Medicine, Cleveland, Ohio
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L. Wolansky
bUniversity Hospitals Case Medical Center (L.R., M.C., A.S., L.W., A.G.), Case Western Reserve School of Medicine, Cleveland, Ohio
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M. Pinho
dUniversity of Texas Southwestern Medical Center (M.P., K.J.H.), Dallas, Texas.
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A. Gupta
bUniversity Hospitals Case Medical Center (L.R., M.C., A.S., L.W., A.G.), Case Western Reserve School of Medicine, Cleveland, Ohio
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K.J. Hatanpaa
dUniversity of Texas Southwestern Medical Center (M.P., K.J.H.), Dallas, Texas.
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A. Madabhushi
aFrom the Department of Biomedical Engineering (P.P., A.M., P.T.), Case Western Reserve University, Cleveland, Ohio
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P. Tiwari
aFrom the Department of Biomedical Engineering (P.P., A.M., P.T.), Case Western Reserve University, Cleveland, Ohio
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    Fig 1.

    Box-and-whisker plots showing the distributions of T1WI signal intensities and skewness of COLLAGE entropy values for pure and different grades of CRN for primary and metastatic cases, respectively. A and B, The signal intensities in primary and metastatic cases, respectively. C and D, The COLLAGE skewness values for the same cases. C, The green star and circle represent the cases from site 2 with 75% CRN and 30% CRN, respectively. D, The green star represents the case from site 2 with 50% CRN. P values for the pairs of groups exhibiting statistically significant difference are also shown.

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    Fig 2.

    Gd-C T1WI for CRN from nasopharyngeal carcinoma (A), predominant (>80%) CRN (B), predominant recurrent tumor (<20% CRN) (C), and glioblastoma (0% CRN) (D), and the corresponding COLLAGE entropy maps of the ROIs (E–H).

Tables

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  • Patient cohorts with corresponding diagnosis as identified by an expert neuropathologist on postsurgical specimens

    Site No., Initial DiagnosisCategoryPercentage CRN/Tumor as Identified by ExpertNo. of Cases
    Site 1
        Primary tumorsPredominant tumor<20% CRN, >80% tumor12
    Predominant CRN>80% CRN, <20% tumor10
        Metastatic tumorsPredominant tumor<20% CRN, >80% tumor12
    Predominant CRN>80% CRN, <20% tumor8
    Site 2
        Primary tumorsPredominant tumor<20% CRN, >80% tumor4
    Predominant CRN>80% CRN, <20% tumor1
    Mixed30% CRN, >70% tumor2
        Metastatic tumorsPredominant tumor<20% CRN, >80% tumor1
    Predominant CRN>80% CRN, <20% tumor1
    Mixed50% CRN, 50% tumor1 (50%)
    Site 3
        NPCPure100% CRN13
    TCIA
        GlioblastomaPure100% Tumor10
    • Note:—NPC indicates nasopharyngeal carcinoma.

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American Journal of Neuroradiology: 40 (3)
American Journal of Neuroradiology
Vol. 40, Issue 3
1 Mar 2019
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P. Prasanna, L. Rogers, T.C. Lam, M. Cohen, A. Siddalingappa, L. Wolansky, M. Pinho, A. Gupta, K.J. Hatanpaa, A. Madabhushi, P. Tiwari
Disorder in Pixel-Level Edge Directions on T1WI Is Associated with the Degree of Radiation Necrosis in Primary and Metastatic Brain Tumors: Preliminary Findings
American Journal of Neuroradiology Mar 2019, 40 (3) 412-417; DOI: 10.3174/ajnr.A5958

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Disorder in Pixel-Level Edge Directions on T1WI Is Associated with the Degree of Radiation Necrosis in Primary and Metastatic Brain Tumors: Preliminary Findings
P. Prasanna, L. Rogers, T.C. Lam, M. Cohen, A. Siddalingappa, L. Wolansky, M. Pinho, A. Gupta, K.J. Hatanpaa, A. Madabhushi, P. Tiwari
American Journal of Neuroradiology Mar 2019, 40 (3) 412-417; DOI: 10.3174/ajnr.A5958
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