Open Access

Disorder in Pixel-Level Edge Directions on T1WI Is Associated with the Degree of Radiation Necrosis in Primary and Metastatic Brain Tumors: Preliminary Findings

P. Prasanna, L. Rogers, T.C. Lam, M. Cohen, A. Siddalingappa, L. Wolansky, M. Pinho, A. Gupta, K.J. Hatanpaa, A. Madabhushi and P. Tiwari

Article Figures & Data

Figures

  • Fig 1.

    Box-and-whisker plots showing the distributions of T1WI signal intensities and skewness of COLLAGE entropy values for pure and different grades of CRN for primary and metastatic cases, respectively. A and B, The signal intensities in primary and metastatic cases, respectively. C and D, The COLLAGE skewness values for the same cases. C, The green star and circle represent the cases from site 2 with 75% CRN and 30% CRN, respectively. D, The green star represents the case from site 2 with 50% CRN. P values for the pairs of groups exhibiting statistically significant difference are also shown.

  • Fig 2.

    Gd-C T1WI for CRN from nasopharyngeal carcinoma (A), predominant (>80%) CRN (B), predominant recurrent tumor (<20% CRN) (C), and glioblastoma (0% CRN) (D), and the corresponding COLLAGE entropy maps of the ROIs (E–H).

Tables

  • Patient cohorts with corresponding diagnosis as identified by an expert neuropathologist on postsurgical specimens

    Site No., Initial DiagnosisCategoryPercentage CRN/Tumor as Identified by ExpertNo. of Cases
    Site 1
        Primary tumorsPredominant tumor<20% CRN, >80% tumor12
    Predominant CRN>80% CRN, <20% tumor10
        Metastatic tumorsPredominant tumor<20% CRN, >80% tumor12
    Predominant CRN>80% CRN, <20% tumor8
    Site 2
        Primary tumorsPredominant tumor<20% CRN, >80% tumor4
    Predominant CRN>80% CRN, <20% tumor1
    Mixed30% CRN, >70% tumor2
        Metastatic tumorsPredominant tumor<20% CRN, >80% tumor1
    Predominant CRN>80% CRN, <20% tumor1
    Mixed50% CRN, 50% tumor1 (50%)
    Site 3
        NPCPure100% CRN13
    TCIA
        GlioblastomaPure100% Tumor10
    • Note:—NPC indicates nasopharyngeal carcinoma.

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