Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study

G. Pontillo, S. Cocozza, R. Lanzillo, C. Russo, M.D. Stasi, C. Paolella, E.A. Vola, C. Criscuolo, P. Borrelli, G. Palma, E. Tedeschi, V.B. Morra, A. Elefante and A. Brunetti
American Journal of Neuroradiology January 2019, 40 (1) 99-106; DOI: https://doi.org/10.3174/ajnr.A5915
G. Pontillo
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
dInstitute of Biostructure and Bioimaging (G.P.), National Research Council, Naples, Italy.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Pontillo
S. Cocozza
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Cocozza
R. Lanzillo
bNeurosciences and Reproductive and Odontostomatological Sciences (R.L., C.C., V.B.M.), University of Naples “Federico II”, Naples, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Lanzillo
C. Russo
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Russo
M.D. Stasi
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.D. Stasi
C. Paolella
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Paolella
E.A. Vola
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E.A. Vola
C. Criscuolo
bNeurosciences and Reproductive and Odontostomatological Sciences (R.L., C.C., V.B.M.), University of Naples “Federico II”, Naples, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Criscuolo
P. Borrelli
cIRCCS SDN (P.B.), Naples, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P. Borrelli
G. Palma
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Palma
E. Tedeschi
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Tedeschi
V.B. Morra
bNeurosciences and Reproductive and Odontostomatological Sciences (R.L., C.C., V.B.M.), University of Naples “Federico II”, Naples, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for V.B. Morra
A. Elefante
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Elefante
A. Brunetti
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Brunetti
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading
Submit a Response to This Article
Compose eLetter

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. [email protected]
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests

Vertical Tabs

Jump to comment:

No eLetters have been published for this article.
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 40 (1)
American Journal of Neuroradiology
Vol. 40, Issue 1
1 Jan 2019
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
G. Pontillo, S. Cocozza, R. Lanzillo, C. Russo, M.D. Stasi, C. Paolella, E.A. Vola, C. Criscuolo, P. Borrelli, G. Palma, E. Tedeschi, V.B. Morra, A. Elefante, A. Brunetti
Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study
American Journal of Neuroradiology Jan 2019, 40 (1) 99-106; DOI: 10.3174/ajnr.A5915

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study
G. Pontillo, S. Cocozza, R. Lanzillo, C. Russo, M.D. Stasi, C. Paolella, E.A. Vola, C. Criscuolo, P. Borrelli, G. Palma, E. Tedeschi, V.B. Morra, A. Elefante, A. Brunetti
American Journal of Neuroradiology Jan 2019, 40 (1) 99-106; DOI: 10.3174/ajnr.A5915
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Leveraging Hand-Crafted Radiomics on Multicenter FLAIR MRI for Predicting Disability Progression in People with Multiple Sclerosis
  • Quantitative MRI in Multiple Sclerosis: From Theory to Application
  • Lesion Volume in Relapsing Multiple Sclerosis is Associated with Perivascular Space Enlargement at the Level of the Basal Ganglia
  • A Combined Radiomics and Machine Learning Approach to Overcome the Clinicoradiologic Paradox in Multiple Sclerosis
  • Tissue damage detected by quantitative gradient echo MRI correlates with clinical progression in non-relapsing progressive MS
  • Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis
  • The Development of Subcortical Gray Matter Atrophy in Multiple Sclerosis: One Size Does Not Fit All
  • What Causes Deep Gray Matter Atrophy in Multiple Sclerosis?
  • Crossref (44)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Applications of deep learning techniques for automated multiple sclerosis detection using magnetic resonance imaging: A review
    Afshin Shoeibi, Marjane Khodatars, Mahboobeh Jafari, Parisa Moridian, Mitra Rezaei, Roohallah Alizadehsani, Fahime Khozeimeh, Juan Manuel Gorriz, Jónathan Heras, Maryam Panahiazar, Saeid Nahavandi, U. Rajendra Acharya
    Computers in Biology and Medicine 2021 136
  • Decreasing brain iron in multiple sclerosis: The difference between concentration and content in iron MRI
    Ferdinand Schweser, Jesper Hagemeier, Michael G Dwyer, Niels Bergsland, Simon Hametner, Bianca Weinstock‐Guttman, Robert Zivadinov
    Human Brain Mapping 2021 42 5
  • Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis
    G. Pontillo, M. Petracca, S. Monti, M. Quarantelli, C. Criscuolo, R. Lanzillo, E. Tedeschi, A. Elefante, V. Brescia Morra, A. Brunetti, S. Cocozza, G. Palma
    American Journal of Neuroradiology 2021 42 7
  • Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis
    Maria Petracca, Giuseppe Pontillo, Marcello Moccia, Antonio Carotenuto, Sirio Cocozza, Roberta Lanzillo, Arturo Brunetti, Vincenzo Brescia Morra
    Brain Sciences 2021 11 3
  • Dose Calculation Algorithms for External Radiation Therapy: An Overview for Practitioners
    Fortuna De Martino, Stefania Clemente, Christian Graeff, Giuseppe Palma, Laura Cella
    Applied Sciences 2021 11 15
  • White matter rather than gray matter damage characterizes essential tremor
    Sara Pietracupa, Matteo Bologna, Komal Bharti, Gabriele Pasqua, Silvia Tommasin, Francesca Elifani, Giulia Paparella, Nikolaos Petsas, Giovanni Grillea, Alfredo Berardelli, Patrizia Pantano
    European Radiology 2019 29 12
  • MRI biomarkers of disease progression and conversion to secondary-progressive multiple sclerosis
    Eleonora Tavazzi, Robert Zivadinov, Michael G. Dwyer, Dejan Jakimovski, Tarun Singhal, Bianca Weinstock-Guttman, Niels Bergsland
    Expert Review of Neurotherapeutics 2020 20 8
  • Stratification of multiple sclerosis patients using unsupervised machine learning: a single-visit MRI-driven approach
    Giuseppe Pontillo, Simone Penna, Sirio Cocozza, Mario Quarantelli, Michela Gravina, Roberta Lanzillo, Stefano Marrone, Teresa Costabile, Matilde Inglese, Vincenzo Brescia Morra, Daniele Riccio, Andrea Elefante, Maria Petracca, Carlo Sansone, Arturo Brunetti
    European Radiology 2022 32 8
  • Magnetic Resonance Imaging in Primary Progressive Multiple Sclerosis Patients
    Malgorzata Siger
    Clinical Neuroradiology 2022 32 3
  • A Combined Radiomics and Machine Learning Approach to Overcome the Clinicoradiologic Paradox in Multiple Sclerosis
    G. Pontillo, S. Tommasin, R. Cuocolo, M. Petracca, N. Petsas, L. Ugga, A. Carotenuto, C. Pozzilli, R. Iodice, R. Lanzillo, M. Quarantelli, V. Brescia Morra, E. Tedeschi, P. Pantano, S. Cocozza
    American Journal of Neuroradiology 2021 42 11

More in this TOC Section

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • NCCT vs. MRI for Brain Atrophy in Acute Stroke
  • Clinical Outcomes After Chiari I Decompression
Show more ADULT BRAIN

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire