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Abstract

Absorption after subarachnoid and subdural administration of iohexol, 51Cr-EDTA, and 125I-albumin to rabbits.

E Holtz, A A Michelet and T Jacobsen
American Journal of Neuroradiology May 1983, 4 (3) 338-341;
E Holtz
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A A Michelet
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T Jacobsen
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Abstract

The absorption of the nonionic contrast medium iohexol, the clearance tracer 51Cr-ethylenediaminetetraacetic acid, and the blood-pool marker 125I-human serum albumin was studied after subarachnoid and subdural injection in rabbits. Subdural deposition of the contrast medium and 51Cr-ethylenediaminetetraacetic acid resulted in a faster absorption rate and higher achieved blood levels than a subarachnoid injection of the two substances, where a slow absorption to lower blood concentrations was observed. No significant differences in absorption rate could be shown after subdural and subarachnoid administration of iodine-labelled albumin. The excretion of iohexol was observed for 1 week after the intrathecal injection. For both the subdural and subarachnoid depositions, about 83% of the injected iohexol was found in urine within 24 hr after injection. The total recovery of iohexol after 1 week was 96% (range, 87%-101%).

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American Journal of Neuroradiology
Vol. 4, Issue 3
1 May 1983
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E Holtz, A A Michelet, T Jacobsen
Absorption after subarachnoid and subdural administration of iohexol, 51Cr-EDTA, and 125I-albumin to rabbits.
American Journal of Neuroradiology May 1983, 4 (3) 338-341;

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Absorption after subarachnoid and subdural administration of iohexol, 51Cr-EDTA, and 125I-albumin to rabbits.
E Holtz, A A Michelet, T Jacobsen
American Journal of Neuroradiology May 1983, 4 (3) 338-341;
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