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Improved Turnaround Times | Median time to first decision: 12 days

Review ArticleSpine Imaging and Spine Image-Guided Interventions
Open Access

Review of the Imaging Features of Benign Osteoporotic and Malignant Vertebral Compression Fractures

J.T. Mauch, C.M. Carr, H. Cloft and F.E. Diehn
American Journal of Neuroradiology September 2018, 39 (9) 1584-1592; DOI: https://doi.org/10.3174/ajnr.A5528
J.T. Mauch
aFrom the Department of Radiology, Mayo Clinic, Rochester, Minnesota.
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C.M. Carr
aFrom the Department of Radiology, Mayo Clinic, Rochester, Minnesota.
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H. Cloft
aFrom the Department of Radiology, Mayo Clinic, Rochester, Minnesota.
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F.E. Diehn
aFrom the Department of Radiology, Mayo Clinic, Rochester, Minnesota.
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    Fig 1.

    Abnormal pedicle marrow signal in a malignant VCF. A, Sagittal T1WI of the lumbar spine demonstrates a malignant VCF of L3 with loss of the high T1 normal marrow signal within the pedicle (arrow), indicating tumor infiltration. B, Sagittal T1WI of the lumbar spine demonstrates a typical benign VCF of L1 anteriorly, with preservation of the normal high T1 marrow signal within the pedicle (arrow).

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    Fig 2.

    Fracture lines without cortical destruction in a benign VCF. Axial CT with bone windows shows the linear and well-delineated borders of the slightly displaced bone fragments within this benign VCF, an example of the puzzle sign.

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    Fig 3.

    Masslike extension into the paravertebral and epidural space in a malignant VCF. A, Sagittal T1WI of the thoracic spine demonstrates a malignant VCF of T9 with loss of the high T1 normal marrow signal within the vertebral body and convex bowing of the posterior cortex (arrow), both signs indicating a malignant fracture. B, Axial postcontrast T1WI with fat saturation of the T9 fracture demonstrates an irregular enhancing mass (arrow) extending into the right paraspinal soft tissues and the epidural space in this malignant VCF.

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    Fig 4.

    Diffuse abnormal marrow signal in a malignant VCF. Sagittal T1WI of the lumbar spine demonstrates a malignant VCF of L2 with marked complete replacement of the normal high T1 vertebral body marrow signal. The diffuse T1 hypointensity indicates tumor infiltration. Note the convex, expanded border of the posterior vertebral body versus the normal posterior concavity of the adjacent vertebral bodies.

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    Fig 5.

    Increased enhancement in malignant VCF. Sagittal T1WI postgadolinium with fat saturation of the lumbar spine demonstrates an enhancing malignant VCF of L2. The enhancement is greater than that of the normal adjacent vertebral bodies. Also demonstrated is an expanded posterior convex border.

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    Fig 6.

    Retropulsion of a bone fragment in a benign VCF. Sagittal T1WI (A) and T2WI (B) with fat saturation of the lumbar spine demonstrate a retropulsed bone fragment (arrow) compressing the thecal sac and narrowing the spinal canal in this benign VCF (C), best seen on the axial T2WI. A similar appearance is demonstrated on the axial (D) and sagittal (E) reformatted thoracic spine CT scans.

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    Fig 7.

    Linear horizontal fracture line in a benign VCF. As seen on the sagittal reformat from a thoracic spine CT in bone windows (A), there is a lucent fracture line (arrow) paralleling the superior endplate of T11. On MR imaging, this fracture is seen as a linear horizontal line (arrow) of T1 and T2 hypointensity through the T11 vertebral body, T1WI (B) and T2WI (C).

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    Fig 8.

    Fluid cleft in a benign VCF. Sagittal T2WI with fat saturation of the lumbar spine demonstrates a triangular fluid cleft (arrow) seen within this benign VCF.

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    Fig 9.

    DWI of benign and malignant VCFs. Multiple benign osteoporotic VCFs (A–C, arrows) are seen in the lower thoracic spine. Sagittal DWI (A) and the corresponding ADC map (B) demonstrate the absence of diffusion restriction. Sagittal fat-saturated T2WI (C) demonstrates T2 hyperintensity about the fracture lines compatible with edema from an acute/subacute fracture. In contrast, malignant lymphomatous involvement of T12 (D–F, arrow) demonstrates diffuse diffusion restriction (D) with corresponding low ADC values (E). On the sagittal T1WI (F), there is slight loss of height of the superior and inferior endplates and diffuse T1 hypointensity compatible with marrow replacement.

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    Fig 10.

    FDG avid malignant VCF. Axial non-attenuation-corrected PET (A) at the level of the malignant lumbar VCF with increased FDG activity throughout the vertebral body and into the left pedicle. Corresponding axial T1WI (B) shows the area of low T1 signal tumor infiltration throughout the vertebral body and left pedicle.

Tables

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  • Summary of imaging features of benign and malignant VCFs

    ModalityBenign VCF FeaturesMalignant VCF Features
    MRI: morphologyNormal posterior element signal,20 retropulsed bone fragments,9,12,14,17 additional benign VCFs18,19Abnormal posterior element signal,9–19 epidural or paravertebral soft-tissue mass,9,10,12–15,17–19 expanded posterior vertebral contour,9,11,12,14,18,24 metastasis in other vertebrae9,14,18
    MRI: signal and enhancement patternsPreserved normal marrow signal,9–12,14,15,17 regular margins,13,17,28 linear horizontal hypointense T1/T2 band,4,9,11,14,18 fluid sign,9,18,19,26 normal enhancement relative to adjacent vertebrae and at 3 mo12,13,15,28Geographic replacement of normal marrow signal,11,12,14–18,24,28 irregular margins,13,17,28 increased enhancement relative to adjacent vertebrae and at 3 mo12,13,15,28
    MRI: diffusionNo restricted diffusion18,27,30,32–45Increased restricted diffusion18,27,30,32–45
    MRI: chemical shiftLoss of SI on opposed-phase18,51–53No change or slight loss of SI on opposed-phase,18,51–53 ratio of opposed-phase to in-phase SI > 0.8–1.018,51–53
    CTRetropulsed bone,54,55 puzzle sign,10,54,55 sharp fracture lines,10,54,55 intravertebral vacuum phenomenenon55Bone destruction,10,54,55 epidural or focal paravertebral soft tissue mass54,55
    PETSUV 2 SDs below liver SUV57–60SUV of >3–4.7 or 2 SDs above liver SUV57–60
    SPECTVertebral body and/or facet joint uptake63Vertebral body with pedicle and/or spinous process uptake,63 marginal uptake in cold lesion63
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American Journal of Neuroradiology: 39 (9)
American Journal of Neuroradiology
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1 Sep 2018
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Cite this article
J.T. Mauch, C.M. Carr, H. Cloft, F.E. Diehn
Review of the Imaging Features of Benign Osteoporotic and Malignant Vertebral Compression Fractures
American Journal of Neuroradiology Sep 2018, 39 (9) 1584-1592; DOI: 10.3174/ajnr.A5528

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Review of the Imaging Features of Benign Osteoporotic and Malignant Vertebral Compression Fractures
J.T. Mauch, C.M. Carr, H. Cloft, F.E. Diehn
American Journal of Neuroradiology Sep 2018, 39 (9) 1584-1592; DOI: 10.3174/ajnr.A5528
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