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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleHead and Neck Imaging
Open Access

Imaging and Surgical Findings in Patients with Hemi-Laryngopharyngeal Spasm and the Potential Role of MRI in the Diagnostic Work-Up

J. Avecillas-Chasin, M.G. Kozoriz, J.R. Shewchuk, M.K.S. Heran and C.R. Honey
American Journal of Neuroradiology December 2018, 39 (12) 2366-2370; DOI: https://doi.org/10.3174/ajnr.A5851
J. Avecillas-Chasin
aFrom the Department of Surgery (J.A.-C., C.R.H.), Division of Neurosurgery
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M.G. Kozoriz
bDepartment of Radiology (M.G.K., J.R.S., M.K.S.H.), University of British Columbia, Vancouver, British Columbia, Canada
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J.R. Shewchuk
bDepartment of Radiology (M.G.K., J.R.S., M.K.S.H.), University of British Columbia, Vancouver, British Columbia, Canada
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M.K.S. Heran
bDepartment of Radiology (M.G.K., J.R.S., M.K.S.H.), University of British Columbia, Vancouver, British Columbia, Canada
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C.R. Honey
aFrom the Department of Surgery (J.A.-C., C.R.H.), Division of Neurosurgery
cVancouver General Hospital (C.R.H.), Vancouver, British Columbia, Canada.
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    Fig 1.

    Grading system. The vagus nerve was rated separately for the proximal (3 mm from the brain stem) and the distal portions. A, Grade I: “no vessel contact” (white arrow). B, Grade II: “contact,” which was defined as no visible CSF between the blood vessel and the nerve but no displacement of the normal trajectory of the nerve (white arrow). C, Grade III: “compression,” which was defined as displacement of the normal trajectory of the nerve (white arrow). D, Grade I: Oblique projection showing the vagus nerve (white arrow) in contact with the PICA (black arrow). The glossopharyngeal nerve (gray arrow) is shown above the vagus nerve. E, Oblique projection of the IX/X complex close to the jugular foramen. It was possible to see the upper glossopharyngeal nerve more anteriorly and superiorly moving lateral into the foramen, and the vagus nerve branches were below this.

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    Fig 2.

    Patient 1. A, MR imaging shows neurovascular conflict of the PICA (arrow) with the proximal part of the vagus nerve. B, Intraoperative findings show the loop of the PICA (asterisk) pulsating against the caudal rootlets of the vagus nerve (X). IX indicates glossopharyngeal nerve; crXI, cranial root of the accessory nerve; S, superior; I, inferior; R, right; L, left.

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    Fig 3.

    Patient 2. A, Axial view of MR imaging shows compression of the vagus nerve by the right PICA from the anterior direction (arrow). B, The coronal-oblique plane shows the vessel loop of the PICA (arrow). VII/VIII indicates the facial and vestibulocochlear nerve complex; IX/X, the glossopharyngeal and vagus nerve complex. C, Intraoperative findings confirm that the vessel loop of the PICA (arrow) is pulsating against the anterior aspect of the vagus nerve (X). IX indicates the glossopharyngeal nerve; XI, the accessory nerve; S, superior; I, inferior; R, right; L, left.

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    Fig 4.

    Case 3. A, Axial view of MR imaging shows neurovascular conflict of the left PICA (asterisk) and the vagus nerve. B, The coronal-oblique plane shows the loop of the left PICA (asterisk) in contact with the proximal part of the rootlets of the vagus nerve (X), which is also in contact with the left cerebellar tonsil (T). C, Intraoperative findings. After gentle retraction of the cerebellum and part of the left tonsil, the left PICA loop (asterisk) is found in contact with the proximal part of the vagus nerve (X). S indicates superior; I, inferior; R, right; L, left.

Tables

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  • Clinical and demographic data of our patients with HELPS

    Patient No.Age/SexSymptomsOffending VesselGrading of NVC
    165/MEpisodic throat contractions and coughingLeft PICA2
    243/FEpisodic throat contractions, coughing, and vocal changesRight PICA3
    332/FEpisodic left-sided throat contractions, choking, and vocal changesLeft PICA2
    • Note:—NVC indicates neurovascular conflict.

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American Journal of Neuroradiology: 39 (12)
American Journal of Neuroradiology
Vol. 39, Issue 12
1 Dec 2018
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Cite this article
J. Avecillas-Chasin, M.G. Kozoriz, J.R. Shewchuk, M.K.S. Heran, C.R. Honey
Imaging and Surgical Findings in Patients with Hemi-Laryngopharyngeal Spasm and the Potential Role of MRI in the Diagnostic Work-Up
American Journal of Neuroradiology Dec 2018, 39 (12) 2366-2370; DOI: 10.3174/ajnr.A5851

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Imaging and Surgical Findings in Patients with Hemi-Laryngopharyngeal Spasm and the Potential Role of MRI in the Diagnostic Work-Up
J. Avecillas-Chasin, M.G. Kozoriz, J.R. Shewchuk, M.K.S. Heran, C.R. Honey
American Journal of Neuroradiology Dec 2018, 39 (12) 2366-2370; DOI: 10.3174/ajnr.A5851
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Hemi-laryngopharyngeal Spasm (HeLPS): Defining a New Clinical Entity
    Amanda Hu, Murray Morrison, Christopher R. Honey
    Annals of Otology, Rhinology & Laryngology 2020 129 9
  • Supraglottic Botulinum Toxin Improves Symptoms in Patients with Laryngeal Sensory Dysfunction Manifesting as Abnormal Throat Sensation and/or Chronic Refractory Cough
    Daniel Novakovic, Meet Sheth, Thomas Stewart, Katrina Sandham, Catherine Madill, Antonia Chacon, Duy Duong Nguyen
    Journal of Clinical Medicine 2021 10 23
  • Vagus Associated Neurogenic Cough Occurring Due to Unilateral Vascular Encroachment of Its Root: A Case Report and Proof of Concept of VANCOUVER Syndrome
    Christopher R. Honey, Marie T. Krüger, Murray D. Morrison, Baljinder S. Dhaliwal, Amanda Hu
    Annals of Otology, Rhinology & Laryngology 2020 129 5
  • Microvascular Decompression for Concurrent Trigeminal Neuralgia and Hemi-Laryngopharyngeal Spasm: A Case Report
    Michiru Katayama, Shusaku Noro, Bunsho Asayama, Yuki Amano, Masahiro Okuma, Kaori Honjo, Yoshinobu Seo, Hirohiko Nakamura
    Operative Neurosurgery 2023 24 2
  • Episodic symptoms caused by neurovascular conflict of vagus nerve due to hemilateral anterior inferior cerebellar artery
    Hui Lv, Peihong Li, Xiaoyan Long, Zheng Xiao, Luo Zhou
    Journal of Neurology 2023 270 12
  • The silent scream: Unraveling vagal nerve neuralgia; VANCOUVER syndrome and HeLPS
    Erfan Shahabinejad, Amirreza Shakoeizadeh, Mina Jafari, Shayesteh Haghighi, Nima Rafati, Seyyed Mohammad Alipour, Mahla Esmaeili, Behina Salarian, Farid Abbaspour, Florian Roser, Abdulrahman Albakr, Hamid Borghei-Razavi
    Clinical Neurology and Neurosurgery 2025 254
  • The vagal rhizopathies
    Christopher R. Honey
    Frontiers in Neurology 2025 15

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