Article Figures & Data
Figures
- Fig 1.
Diagram of the study group. PTMC indicates papillary thyroid microcarcinoma.
- Fig 2.
Right thyroid with a palpable lesion in a 20-year-old man. US scan of the right thyroid reveals a 25-mm hypoechoic nodule (arrow) with an irregular margin and microcalcification (A). The cytologic diagnosis from US-FNA is benign (B, HE stain, magnification 4X10) and positive for the BRAF V600E mutation. The nodule is confirmed as PTC by surgical pathology (C, HE stain, magnification 10X10).
- Fig 3.
An incidentally found nodule in a 69-year-old woman during US screening. US scans reveal a 13-mm hypoechoic nodule (arrrow) with microcalcification in the right thyroid (A). The cytologic diagnosis from US-FNA is benign (B, HE stain, magnification 4X10) and positive for the BRAF V600E mutation using direct DNA sequencing. The nodule is confirmed as a nodular goiter with underlying lymphocytic thyroiditis (C, HE stain, magnification 10X10).
Tables
- Table 1:
Clinical and US features and characteristics of thyroid nodules with benign cytology
Positive for BRAF V600E Mutation Negative for BRAF V600E Mutation P No. of nodules 36 256 Diagnosis <.001 Malignant 31 6 Benign 5 250 Age (mean) (yr) 44.7 ± 11.3 47.3 ± 13.9 .31 Sex <.001 F 2 229 M 10 27 Mean size of nodules (mm) 9.4 ± 3.7 11.8 ± 4.1 .41 5–10 23 145 >10 13 112 No. of suspicious US features <.001 1 11 243 2 17 12 3 7 1 4 1 0 Echogenicity .11 Hyper- or isoechoic 1 15 Hypoechoic 30 229 Marked hypoechoic 5 12 Margin .18 Circumscribed 15 137 Not circumscribed 21 119 Calcification <.001 No calcifications 12 161 Microcalcification 21 72 Macrocalcification 3 23 Shape <.01 Parallel 16 167 Taller-than-wide 20 89 Evidence of extrathyroidal growth 0 0 Pathologic adenopathy 2 0 - Table 2:
Demographics of 5 patients whose nodules had benign cytology results and were positive for the BRAF V600E mutation
No. Age (yr) Sex No. of Suspicious US Features Size of the Nodules (mm) Pathology Results 1 48 F 1 5.3 Nodule goiter 2 39 F 2 11 Fibrotic nodule with calcification 3 45 M 2 9 Nodule goiter 4 45 M 1 6 Nodule goiter with underlying lymphocytic thyroiditis 5 69 F 3 13 Nodule goiter with underlying lymphocytic thyroiditis
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