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Research ArticleNeurointervention

How to Size Intracranial Aneurysms: A Phantom Study of Invasive and Noninvasive Methods

D. Behme, N. Amelung, T. Khakzad and M.-N. Psychogios
American Journal of Neuroradiology December 2018, 39 (12) 2291-2296; DOI: https://doi.org/10.3174/ajnr.A5866
D. Behme
aFrom the Department of Diagnostic and Interventional Neuroradiology, University Medical Center Göttingen, Göttingen, Germany.
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N. Amelung
aFrom the Department of Diagnostic and Interventional Neuroradiology, University Medical Center Göttingen, Göttingen, Germany.
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T. Khakzad
aFrom the Department of Diagnostic and Interventional Neuroradiology, University Medical Center Göttingen, Göttingen, Germany.
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M.-N. Psychogios
aFrom the Department of Diagnostic and Interventional Neuroradiology, University Medical Center Göttingen, Göttingen, Germany.
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    Fig 1.

    Experimental setup of an aneurysm model inside a human skull on the biplane Artis Q angiosuite.

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    Fig 2.

    Examples of the different image techniques applied: MPR and VRT of MDCTA images (A and B), MPR and VRT images of FDCTA images (C and D), MPR and VRT images obtained from a 3D-DSA run (E and F), short object-to-detector distance DSA image no optimal projection (G), and optimized projection DSA image with short object-to-detector distance (H, DSA rotation near).

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    Fig 3.

    Bland-Altman plots comparing all techniques with DSA rotation near MDCTA MPR (A) versus DSA rotation near MDCTA VRT (B) versus DSA rotation near FDCTA MPR (C) versus DSA rotation near FDCTA VRT (D) versus DSA rotation near 3D DSA MPR (E) versus DSA rotation near 3D DSA VRT (F) versus DSA rotation near DSA long (G) versus DSA rotation near DSA middle (H) versus DSA rotation near DSA rotation long (I) versus DSA rotation near DSA rotation middle versus DSA rotation near (J).

Tables

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    Table 1:

    Examination parameters

    MDCTAFDCTA3D DSADSA
    FOV (cm)10 × 1010 × 1010 × 1015 × 15
    Matrix size512 × 512512 × 512512 × 5121024 × 1024
    In-plane resolutions (mm)0.20.20.290.15
    Cumulative dose (mGy)3040953
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    Table 2:

    Aneurysm model 1—mean of differences in known aneurysm sizes (all 3 dimensions combined)

    Statistics/TechniqueMean (mm)SDSE of MeanLower 95% CIUpper 95% CI
    FDCTA MPR0.751.640.240.261.24
    FDCTA VRT0.990.690.100.781.20
    MDCTA MPR1.151.260.190.771.52
    MDCTA VRT1.910.690.101.702.11
    DSA long0.500.840.130.250.75
    DSA middle0.650.520.080.490.80
    DSA near0.660.710.110.450.87
    3D DSA MPR1.101.550.230.631.56
    3D DSA VRT1.190.690.100.981.40
    DSA rotation long−0.051.710.25−0.560.47
    DSA rotation middle−0.150.640.09−0.340.04
    DSA rotation near−0.070.610.09−0.250.18
    • Note:—SE indicates standard error.

    • View popup
    Table 3:

    Aneurysm model 2—mean of differences in known aneurysm sizes (all 3 dimensions combined)

    Statistics/TechniqueMean (mm)SDSE of MeanLower 95% CIUpper 95% CI
    FDCTA MPR0.620.600.090.440.79
    FDCTA VRT0.400.480.070.250.54
    MDCTA MPR0.540.310.050.450.63
    MDCTA VRT0.830.370.060.720.94
    DSA long0.570.690.100.370.78
    DSA middle0.510.660.100.310.70
    DSA near0.630.730.110.410.85
    3D DSA MPR0.410.400.060.290.53
    3D DSA VRT0.680.490.070.530.82
    DSA rotation long−0.050.340.05−0.150.05
    DSA rotation middle0.170.390.060.0520.28
    DSA rotation near0.120.250.040.050.20
    • Note:—SE indicates standard error.

    • View popup
    Table 4:

    Statistical analyses of the Bland-Altman plots comparing all techniques against DSA rotation “near” images

    Statistics/TechniqueArithmetic Mean Differences (95% CI)Lower Limit (95% CI)Upper Limit (95% CI)
    FDCTA MPR−0.64 (−0.91 to −0.37)−3.14 (−3.60 to −2.68)1.86 (1.40–2.32)
    FDCTA VRT−0.67 (−0.86 to −0.49)−2.37 (−2.68 to −2.06)1.02 (0.71–1.33)
    MDCTA MPR−0.84 (−1.05 to −0.62)−2.89 (−3.27 to −2.52)1.22 (0.85–1.60)
    MDCTA VRT−1.34 (−1.56 to −1.13)−3.37 (−3.74 to −2.99)0.68 (0.31–1.05)
    DSA long−0.48 (−0.63 to −0.33)−1.90 (−2.16 to −1.64)0.94 (0.68–1.20)
    DSA middle−0.51 (−0.67 to −0.36)−1.98 (−2.25 to −1.71)0.95 (0.68–1.22)
    DSA near−0.58 (−0.75 to −0.41)−2.15 (−2.44 to −1.86)0.99 (0.70–1.28)
    3D DSA MPR−0.72 (−0.98 to −0.46)−3.19 (−3.64 to −2.74)1.75 (1.30–2.20)
    3D DSA VRT−0.86 (−1.03 to −0.69)−2.49 (−2.9 to −2.19)0.77 (0.47–1.07)
    DSA rotation long0.89 (−0.04 to −0.21)−1.13 (−1.36 to −0.91)1.31 (1.09–1.54)
    DSA rotation middle0.01 (−0.08 to −11)−0.89 (−1.05 to −0.71)0.91 (0.75–1.08)
    • View popup
    Table 5:

    Interclass correlation coefficient for all techniques

    TechniqueICC95% CI
    FDCTA MPR0.88010.7932–0.9366
    FDCTA VRT0.95180.9078–0.9759
    MDCTA MPR0.95320.9065–0.9772
    MDCTA VRT0.98490.9712–0.9925
    DSA long0.96520.9377–0.9820
    DSA middle0.98380.9705–0.9917
    DSA near0.98060.9648–0.9901
    3D DSA MPR0.90630.7781–0.9577
    3D DSA VRT0.86380.7676–0.9275
    DSA rotation long0.86380.7676–0.9275
    DSA rotation middle0.98340.9700–0.9915
    DSA rotation near0.98550.9737–0.9926
    • Note:—ICC indicates interclass correlation coefficient.

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American Journal of Neuroradiology: 39 (12)
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D. Behme, N. Amelung, T. Khakzad, M.-N. Psychogios
How to Size Intracranial Aneurysms: A Phantom Study of Invasive and Noninvasive Methods
American Journal of Neuroradiology Dec 2018, 39 (12) 2291-2296; DOI: 10.3174/ajnr.A5866

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How to Size Intracranial Aneurysms: A Phantom Study of Invasive and Noninvasive Methods
D. Behme, N. Amelung, T. Khakzad, M.-N. Psychogios
American Journal of Neuroradiology Dec 2018, 39 (12) 2291-2296; DOI: 10.3174/ajnr.A5866
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