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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticlePediatric Neuroimaging
Open Access

Multidelay Arterial Spin-Labeling MRI in Neonates and Infants: Cerebral Perfusion Changes during Brain Maturation

H.G. Kim, J.H. Lee, J.W. Choi, M. Han, S.-M. Gho and Y. Moon
American Journal of Neuroradiology October 2018, 39 (10) 1912-1918; DOI: https://doi.org/10.3174/ajnr.A5774
H.G. Kim
aFrom the Departments of Radiology (H.G.K., J.W.C., M.H.)
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J.H. Lee
bPediatrics (J.H.L.)
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J.W. Choi
aFrom the Departments of Radiology (H.G.K., J.W.C., M.H.)
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M. Han
aFrom the Departments of Radiology (H.G.K., J.W.C., M.H.)
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S.-M. Gho
dMR Clinical Research and Development (S.-M.G.), GE Healthcare Korea, Seoul, Korea.
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Y. Moon
cOffice of Biostatistics (Y.M.), Institute of Medical Sciences, Ajou University School of Medicine, Ajou University Medical Center, Suwon, Korea
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    Fig 1.

    Transit time-corrected CBF is measured within the ROIs: frontal GM (a); caudate (b); occipital GM (c); frontal WM (d); thalamus (e); and occipital WM (f).

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    Fig 2.

    Intragroup comparison of rCBF in the frontal and occipital lobes. A single asterisk indicates P < .05; double asterisks, P < .001.

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    Fig 3.

    Relationship between postmenstrual age and CBF. A single asterisk indicates P < .05; double asterisks, P < .001.

Tables

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    Table 1:

    Regional CBF in the age groups of preterm neonates, term-equivalent-age neonates, and infantsa

    Brain RegionPreterm (n = 13)TEA (n = 13)Infants (n = 6)P ValuePreterm vs TEAPreterm vs InfantsTEA vs Infants
    CBF (mL/100 g/min)
        Caudate21.2 (6.9)25.5 (6.6)42.9 (7.1)<.001.260<.001<.001
        Thalamus27.7 (11.4)32.2 (7.1)36.2 (7.5).168.437.166.658
        F-GM16.8 (4.1)18.8 (3.8)41.8 (12.0)<.001.688<.001<.001
        O-GM19.1 (6.2)21.8 (3.6)49.8 (19.8)<.001.755<.001<.001
        F-WM7.3 (3.1)8.4 (1.9)28.3 (7.5)<.001.744<.001<.001
        O-WM9.9 (3.5)11.9 (3.3)35.6 (14.1)<.001.718<.001<.001
        Whole-brain15.5 (4.2)18.3 (3.3)38.3 (9.5)<.001.388<.001<.001
    rCBF (%)
        Caudate136.4 (25.6)140.8 (28.9)116.0 (25.3).184.911.291.168
        Thalamus174.1 (33.1)177.2 (28.1)96.5 (17.6)<.001.960<.001<.001
        F-GM111.0 (24.9)103.5 (15.2)108.5 (11.6).614.592.965.858
        O-GM122.8 (19.8)120.8 (17.5)127.6 (26.1).791.965.879.773
        F-WM46.7 (16.5)46.3 (7.9)73.9 (7.1)<.001.995<.001<.001
        O-WM63.6 (15.4)65.6 (10.4)90.3 (13.7).001.980.001.001
    • ↵a Data are mean (standard deviation).

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    Table 2:

    Intragroup comparison between rCBF in the frontal and occipital lobesa

    GroupF-GMO-GMP ValueF-WMO-WMP Value
    Preterm111.0 (24.9)122.8 (19.8).73046.7 (16.5)63.6 (15.4).004
    TEA103.5 (15.2)120.8 (17.5).02646.3 (7.9)65.6 (10.4)<.001
    Infants108.5 (11.6)127.6 (26.1).19073.9 (7.1)90.3 (13.7).046
    • ↵a Data are mean (standard deviation) (%).

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American Journal of Neuroradiology: 39 (10)
American Journal of Neuroradiology
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1 Oct 2018
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H.G. Kim, J.H. Lee, J.W. Choi, M. Han, S.-M. Gho, Y. Moon
Multidelay Arterial Spin-Labeling MRI in Neonates and Infants: Cerebral Perfusion Changes during Brain Maturation
American Journal of Neuroradiology Oct 2018, 39 (10) 1912-1918; DOI: 10.3174/ajnr.A5774

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Multidelay Arterial Spin-Labeling MRI in Neonates and Infants: Cerebral Perfusion Changes during Brain Maturation
H.G. Kim, J.H. Lee, J.W. Choi, M. Han, S.-M. Gho, Y. Moon
American Journal of Neuroradiology Oct 2018, 39 (10) 1912-1918; DOI: 10.3174/ajnr.A5774
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