Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • Advancing NeuroMRI with High-Relaxivity Contrast Agents
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • Advancing NeuroMRI with High-Relaxivity Contrast Agents
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates


Improved Turnaround Times | Median time to first decision: 12 days

Research ArticlePediatric Neuroimaging
Open Access

Quantitative Folding Pattern Analysis of Early Primary Sulci in Human Fetuses with Brain Abnormalities

K. Im, A. Guimaraes, Y. Kim, E. Cottrill, B. Gagoski, C. Rollins, C. Ortinau, E. Yang and P.E. Grant
American Journal of Neuroradiology July 2017, 38 (7) 1449-1455; DOI: https://doi.org/10.3174/ajnr.A5217
K. Im
aFrom the Fetal Neonatal Neuroimaging and Developmental Science Center (K.I., A.G., Y.K., E.C., B.G., P.E.G.)
bDivision of Newborn Medicine (K.I., P.E.G.)
eHarvard Medical School (K.I., B.G., C.R., C.O., E.Y., P.E.G.), Boston, Massachusetts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K. Im
A. Guimaraes
aFrom the Fetal Neonatal Neuroimaging and Developmental Science Center (K.I., A.G., Y.K., E.C., B.G., P.E.G.)
gFaculdade de Medicina da USP (A.G.), Sao Paulo, Brazil.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Guimaraes
Y. Kim
aFrom the Fetal Neonatal Neuroimaging and Developmental Science Center (K.I., A.G., Y.K., E.C., B.G., P.E.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Y. Kim
E. Cottrill
aFrom the Fetal Neonatal Neuroimaging and Developmental Science Center (K.I., A.G., Y.K., E.C., B.G., P.E.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Cottrill
B. Gagoski
aFrom the Fetal Neonatal Neuroimaging and Developmental Science Center (K.I., A.G., Y.K., E.C., B.G., P.E.G.)
dRadiology (B.G., E.Y., P.E.G.), Boston Children's Hospital, Boston, Massachusetts
eHarvard Medical School (K.I., B.G., C.R., C.O., E.Y., P.E.G.), Boston, Massachusetts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B. Gagoski
C. Rollins
cthe Departments of Neurology (C.R.)
eHarvard Medical School (K.I., B.G., C.R., C.O., E.Y., P.E.G.), Boston, Massachusetts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Rollins
C. Ortinau
eHarvard Medical School (K.I., B.G., C.R., C.O., E.Y., P.E.G.), Boston, Massachusetts
fDepartment of Pediatrics Newborn Medicine (C.O.), Brigham and Women's Hospital, Boston, Massachusetts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Ortinau
E. Yang
dRadiology (B.G., E.Y., P.E.G.), Boston Children's Hospital, Boston, Massachusetts
eHarvard Medical School (K.I., B.G., C.R., C.O., E.Y., P.E.G.), Boston, Massachusetts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Yang
P.E. Grant
aFrom the Fetal Neonatal Neuroimaging and Developmental Science Center (K.I., A.G., Y.K., E.C., B.G., P.E.G.)
bDivision of Newborn Medicine (K.I., P.E.G.)
dRadiology (B.G., E.Y., P.E.G.), Boston Children's Hospital, Boston, Massachusetts
eHarvard Medical School (K.I., B.G., C.R., C.O., E.Y., P.E.G.), Boston, Massachusetts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P.E. Grant
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Fischl B,
    2. Rajendran N,
    3. Busa E, et al
    . Cortical folding patterns and predicting cytoarchitecture. Cereb Cortex 2008;18:1973–80 doi:10.1093/cercor/bhm225 pmid:18079129
    Abstract/FREE Full Text
  2. 2.↵
    1. Van Essen DC
    . A tension-based theory of morphogenesis and compact wiring in the central nervous system. Nature 1997;385:313–18 doi:10.1038/385313a0 pmid:9002514
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Klyachko VA,
    2. Stevens CF
    . Connectivity optimization and the positioning of cortical areas. Proc Natl Acad Sci U S A 2003;100:7937–41 doi:10.1073/pnas.0932745100 pmid:12796510
    Abstract/FREE Full Text
  4. 4.↵
    1. Sun T,
    2. Hevner RF
    . Growth and folding of the mammalian cerebral cortex: from molecules to malformations. Nat Rev Neurosci 2014;15:217–32 doi:10.1038/nrn3707 pmid:24646670
    CrossRefPubMed
  5. 5.↵
    1. Kostovic I,
    2. Vasung L
    . Insights from in vitro fetal magnetic resonance imaging of cerebral development. Semin Perinatol 2009;33:220–33 doi:10.1053/j.semperi.2009.04.003 pmid:19631083
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Garel C,
    2. Chantrel E,
    3. Brisse H, et al
    . Fetal cerebral cortex: normal gestational landmarks identified using prenatal MR imaging. AJNR Am J Neuroradiol 2001;22:184–89 doi:10.1007/s00381-003-0767-4 pmid:11158907
    Abstract/FREE Full Text
  7. 7.↵
    1. Chi JG,
    2. Dooling EC,
    3. Gilles FH
    . Gyral development of the human brain. Ann Neurol 1977;1:86–93 doi:10.1002/ana.410010109 pmid:560818
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. White T,
    2. Su S,
    3. Schmidt M, et al
    . The development of gyrification in childhood and adolescence. Brain Cogn 2010;72:36–45 doi:10.1016/j.bandc.2009.10.009 pmid:19942335
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Nakamura M,
    2. Nestor PG,
    3. McCarley RW, et al
    . Altered orbitofrontal sulcogyral pattern in schizophrenia. Brain 2007;130:693–707 doi:10.1093/brain/awm007 pmid:17347256
    Abstract/FREE Full Text
  10. 10.↵
    1. Bae BI,
    2. Tietjen I,
    3. Atabay KD, et al
    . Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. Science 2014;343:764–68 doi:10.1126/science.1244392 pmid:24531968
    Abstract/FREE Full Text
  11. 11.↵
    1. Barkovich AJ,
    2. Guerrini R,
    3. Kuzniecky RI, et al
    . A developmental and genetic classification for malformations of cortical development: update 2012. Brain 2012;135:1348–69 doi:10.1093/brain/aws019 pmid:22427329
    Abstract/FREE Full Text
  12. 12.↵
    1. Im K,
    2. Pienaar R,
    3. Paldino MJ, et al
    . Quantification and discrimination of abnormal sulcal patterns in polymicrogyria. Cereb Cortex 2013;23:3007–15 doi:10.1093/cercor/bhs292 pmid:22989584
    Abstract/FREE Full Text
  13. 13.↵
    1. Im K,
    2. Raschle NM,
    3. Smith SA, et al
    . Atypical sulcal pattern in children with developmental dyslexia and at-risk kindergarteners. Cereb Cortex 2016;26:1138–48 doi:10.1093/cercor/bhu305 pmid:25576531
    Abstract/FREE Full Text
  14. 14.↵
    1. Zilles K,
    2. Armstrong E,
    3. Schleicher A, et al
    . The human pattern of gyrification in the cerebral cortex. Anat Embryol (Berl) 1988;179:173–79 doi:10.1007/BF00304699 pmid:3232854
    CrossRefPubMed
  15. 15.↵
    1. Lefevre J,
    2. Germanaud D,
    3. Dubois J, et al
    . Are developmental trajectories of cortical folding comparable between cross-sectional datasets of fetuses and preterm newborns? Cereb Cortex 2016;26:3023–35 doi:10.1093/cercor/bhv123 pmid:26045567
    Abstract/FREE Full Text
  16. 16.↵
    1. Wright R,
    2. Kyriakopoulou V,
    3. Ledig C, et al
    . Automatic quantification of normal cortical folding patterns from fetal brain MRI. Neuroimage 2014;91:21–32 doi:10.1016/j.neuroimage.2014.01.034 pmid:24473102
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Hu HH,
    2. Chen HY,
    3. Hung CI, et al
    . Shape and curvedness analysis of brain morphology using human fetal magnetic resonance images in utero. Brain Struct Funct 2013;218:1451–62 doi:10.1007/s00429-012-0469-3 pmid:23135358
    CrossRefPubMed
  18. 18.↵
    1. Clouchoux C,
    2. du Plessis AJ,
    3. Bouyssi-Kobar M, et al
    . Delayed cortical development in fetuses with complex congenital heart disease. Cereb Cortex 2013;23:2932–43 doi:10.1093/cercor/bhs281 pmid:22977063
    Abstract/FREE Full Text
  19. 19.↵
    1. Clouchoux C,
    2. Kudelski D,
    3. Gholipour A, et al
    . Quantitative in vivo MRI measurement of cortical development in the fetus. Brain Struct Funct 2012;217:127–39 doi:10.1007/s00429-011-0325-x pmid:21562906
    CrossRefPubMed
  20. 20.↵
    1. Dubois J,
    2. Benders M,
    3. Cachia A, et al
    . Mapping the early cortical folding process in the preterm newborn brain. Cereb Cortex 2008;18:1444–54 doi:10.1093/cercor/bhm180 pmid:17934189
    Abstract/FREE Full Text
  21. 21.↵
    1. Habas PA,
    2. Scott JA,
    3. Roosta A, et al
    . Early folding patterns and asymmetries of the normal human brain detected from in utero MRI. Cereb Cortex 2012;22:13–25 doi:10.1093/cercor/bhr053 pmid:21571694
    Abstract/FREE Full Text
  22. 22.↵
    1. Scott JA,
    2. Habas PA,
    3. Rajagopalan V, et al
    . Volumetric and surface-based 3D MRI analyses of fetal isolated mild ventriculomegaly: brain morphometry in ventriculomegaly. Brain Struct Funct 2013;218:645–55 doi:10.1007/s00429-012-0418-1 pmid:22547094
    CrossRefPubMed
  23. 23.↵
    1. Im K,
    2. Pienaar R,
    3. Lee JM, et al
    . Quantitative comparison and analysis of sulcal patterns using sulcal graph matching: a twin study. Neuroimage 2011;57:1077–86 doi:10.1016/j.neuroimage.2011.04.062 pmid:21596139
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Shimony JS,
    2. Smyser CD,
    3. Wideman G, et al
    . Comparison of cortical folding measures for evaluation of developing human brain. Neuroimage 2016;125:780–90 doi:10.1016/j.neuroimage.2015.11.001 pmid:26550941
    CrossRefPubMed
  25. 25.↵
    1. Kuklisova-Murgasova M,
    2. Quaghebeur G,
    3. Rutherford MA, et al
    . Reconstruction of fetal brain MRI with intensity matching and complete outlier removal. Med Image Anal 2012;16:1550–64 doi:10.1016/j.media.2012.07.004 pmid:22939612
    CrossRefPubMed
  26. 26.↵
    1. Cox RW
    . AFNI: what a long strange trip it's been. Neuroimage 2012;62:743–47 doi:10.1016/j.neuroimage.2011.08.056 pmid:21889996
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Serag A,
    2. Aljabar P,
    3. Ball G, et al
    . Construction of a consistent high-definition spatio-temporal atlas of the developing brain using adaptive kernel regression. Neuroimage 2012;59:2255–65 doi:10.1016/j.neuroimage.2011.09.062 pmid:21985910
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Derrfuss J,
    2. Brass M,
    3. von Cramon DY, et al
    . Neural activations at the junction of the inferior frontal sulcus and the inferior precentral sulcus: interindividual variability, reliability, and association with sulcal morphology. Hum Brain Mapp 2009;30:299–311 doi:10.1002/hbm.20501 pmid:18072280
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Im K,
    2. Jo HJ,
    3. Mangin JF, et al
    . Spatial distribution of deep sulcal landmarks and hemispherical asymmetry on the cortical surface. Cereb Cortex 2010;20:602–11 doi:10.1093/cercor/bhp127 pmid:19561060
    Abstract/FREE Full Text
  30. 30.↵
    1. Leordeanu M,
    2. Hebert M
    . A spectral technique for correspondence problems using pairwise constraints. In: ICCV '05 Proceedings of the Tenth IEEE International Conference on Computer Vision, Washington, DC. October 17–21, 2005 doi:10.1109/iccv.2005.20
  31. 31.↵
    1. Schaer M,
    2. Cuadra MB,
    3. Tamarit L, et al
    . A surface-based approach to quantify local cortical gyrification. IEEE Trans Med Imaging 2008;27:161–70 doi:10.1109/TMI.2007.903576 pmid:18334438
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. O'Leary DD,
    2. Chou SJ,
    3. Sahara S
    . Area patterning of the mammalian cortex. Neuron 2007;56:252–69 doi:10.1016/j.neuron.2007.10.010 pmid:17964244
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Hasnain MK,
    2. Fox PT,
    3. Woldorff MG
    . Structure–function spatial covariance in the human visual cortex. Cereb Cortex 2001;11:702–16 doi:10.1093/cercor/11.8.702 pmid:11459760
    Abstract/FREE Full Text
  34. 34.↵
    1. Jones EG,
    2. Pertes A
    1. Welker W
    . Why does cerebral cortex fissure and fold? A review of determinants of gyri and sulci. In: Jones EG, Pertes A, eds. Cerebral Cortex vol. 8B. New York: Plenum; 1990:3–136 doi:10.1007/978-1-4615-3824-0_1
    CrossRef
  35. 35.↵
    1. Chen CH,
    2. Gutierrez ED,
    3. Thompson W, et al
    . Hierarchical genetic organization of human cortical surface area. Science 2012;335:1634–36 doi:10.1126/science.1215330 pmid:22461613
    Abstract/FREE Full Text
  36. 36.↵
    1. Stahl R,
    2. Walcher T,
    3. De Juan Romero C, et al
    . Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate. Cell 2013;153:535–49 doi:10.1016/j.cell.2013.03.027 pmid:23622239
    CrossRefPubMedWeb of Science
  37. 37.↵
    1. Miller JA,
    2. Ding SL,
    3. Sunkin SM, et al
    . Transcriptional landscape of the prenatal human brain. Nature 2014;508:199–206 doi:10.1038/nature13185 pmid:24695229
    CrossRefPubMedWeb of Science
  38. 38.↵
    1. Nishikuni K,
    2. Ribas GC
    . Study of fetal and postnatal morphological development of the brain sulci. J Neurosurg Pediatr 2013;11:1–11 doi:10.3171/2012.9.PEDS12122 pmid:23140215
    CrossRefPubMed
  39. 39.↵
    1. Garel C,
    2. Chantrel E,
    3. Elmaleh M, et al
    . Fetal MRI: normal gestational landmarks for cerebral biometry, gyration and myelination. Childs Nerv Syst 2003;19:422–25 doi:10.1007/s00381-003-0767-4 pmid:12879340
    CrossRefPubMedWeb of Science
  40. 40.↵
    1. Rajagopalan V,
    2. Scott J,
    3. Habas PA, et al
    . Local tissue growth patterns underlying normal fetal human brain gyrification quantified in utero. J Neurosci 2011;31:2878–87 doi:10.1523/JNEUROSCI.5458-10.2011 pmid:21414909
    Abstract/FREE Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 38 (7)
American Journal of Neuroradiology
Vol. 38, Issue 7
1 Jul 2017
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Quantitative Folding Pattern Analysis of Early Primary Sulci in Human Fetuses with Brain Abnormalities
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
K. Im, A. Guimaraes, Y. Kim, E. Cottrill, B. Gagoski, C. Rollins, C. Ortinau, E. Yang, P.E. Grant
Quantitative Folding Pattern Analysis of Early Primary Sulci in Human Fetuses with Brain Abnormalities
American Journal of Neuroradiology Jul 2017, 38 (7) 1449-1455; DOI: 10.3174/ajnr.A5217

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Quantitative Folding Pattern Analysis of Early Primary Sulci in Human Fetuses with Brain Abnormalities
K. Im, A. Guimaraes, Y. Kim, E. Cottrill, B. Gagoski, C. Rollins, C. Ortinau, E. Yang, P.E. Grant
American Journal of Neuroradiology Jul 2017, 38 (7) 1449-1455; DOI: 10.3174/ajnr.A5217
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • A Prospective Multi-Institutional Study Comparing the Brain Development in the Third Trimester between Opioid-Exposed and Nonexposed Fetuses Using Advanced Fetal MR Imaging Techniques
  • Automatic Quantification of Normal Brain Gyrification Patterns and Changes in Fetuses with Polymicrogyria and Lissencephaly Based on MRI
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Pediatric Glioma:Imaging Clusters,Molecular Traits
  • Clinical SVR of Fetal Brain MRI
  • Comparing MRI Perfusion in Pediatric Brain Tumors
Show more PEDIATRIC NEUROIMAGING

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire