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Research ArticlePediatrics

Transient Focal Neurologic Symptoms Correspond to Regional Cerebral Hypoperfusion by MRI: A Stroke Mimic in Children

L.L. Lehman, A.R. Danehy, C.C. Trenor, C.F. Calahan, M.E. Bernson-Leung, R.L. Robertson and M.J. Rivkin
American Journal of Neuroradiology November 2017, 38 (11) 2199-2202; DOI: https://doi.org/10.3174/ajnr.A5296
L.L. Lehman
aFrom the Stroke and Cerebrovascular Center (L.L.L., A.R.D., C.C.T., C.F.C., M.E.B.-L., M.J.R.)
bDepartments of Neurology (L.L.L., C.F.C, M.E.B.-L., M.J.R.)
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  • ORCID record for L.L. Lehman
A.R. Danehy
aFrom the Stroke and Cerebrovascular Center (L.L.L., A.R.D., C.C.T., C.F.C., M.E.B.-L., M.J.R.)
dRadiology (A.R.D., R.L.R., M.J.R.)
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C.C. Trenor III
aFrom the Stroke and Cerebrovascular Center (L.L.L., A.R.D., C.C.T., C.F.C., M.E.B.-L., M.J.R.)
eDivision of Hematology/Oncology (C.C.T.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
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C.F. Calahan
aFrom the Stroke and Cerebrovascular Center (L.L.L., A.R.D., C.C.T., C.F.C., M.E.B.-L., M.J.R.)
bDepartments of Neurology (L.L.L., C.F.C, M.E.B.-L., M.J.R.)
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M.E. Bernson-Leung
aFrom the Stroke and Cerebrovascular Center (L.L.L., A.R.D., C.C.T., C.F.C., M.E.B.-L., M.J.R.)
bDepartments of Neurology (L.L.L., C.F.C, M.E.B.-L., M.J.R.)
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R.L. Robertson
dRadiology (A.R.D., R.L.R., M.J.R.)
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M.J. Rivkin
aFrom the Stroke and Cerebrovascular Center (L.L.L., A.R.D., C.C.T., C.F.C., M.E.B.-L., M.J.R.)
bDepartments of Neurology (L.L.L., C.F.C, M.E.B.-L., M.J.R.)
cPsychiatry (M.J.R)
dRadiology (A.R.D., R.L.R., M.J.R.)
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    Figure.

    A 5-year-old boy presenting with right-sided weakness. Symptoms were improving at the time of the initial MR imaging performed 3 hours after presentation (A–D). A, Susceptibility-weighted imaging shows increased prominence of the cortical veins throughout the left cerebral hemisphere, indicating increased deoxyhemoglobin on the left. B, Collapsed maximum intensity projection from time-of-flight MR angiography shows reduced flow-related enhancement in the left anterior, middle, and posterior cerebral arteries. C, The average trace of the diffusion tensor image shows no abnormality of diffusion. D, Pulsed arterial spin-labeled perfusion-weighted imaging relative CBF map shows a marked decrease in perfusion throughout the left cerebral hemisphere. Follow-up imaging at 4 days after presentation (E–H). E, SWI shows resolution of venous asymmetry. F, MRA shows normal flow-related enhancement in the left anterior, middle, and posterior cerebral arteries. G, Findings of the average trace image continue to be negative. H, Pulsed arterial spin-labeling relative CBF map shows resolution of perfusion asymmetry.

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    Table 1:

    Clinical details of the presentation of the children

    Patient No.Age (yr)SexHeadacheHistory of Migraine HeadacheTime from Presentation to ImagingClinical Symptoms
    115FemaleYesYes4.5 hrRight face and arm weakness, hypoesthesia, hemianopia, aphasia
    213MaleYesNo5.5 hrLeft face and hand paresthesia
    316FemaleYesNo6.75 hrLeft hand and foot paresthesia and weakness
    414MaleYesYes4.5 hrAphasia, right hemianopia
    52MaleNoNo<12 hrRight hemiparesis and hemianopia
    612FemaleYesYes6 hrAphasia
    713MaleYesNo4.25 hrAphasia and right face and arm weakness
    88MaleYesNo11 hrAphasia, bilateral blurry vision, left hand paresthesia
    910MaleYesNo6 hrRight hand paresthesia, confusion
    1011FemaleNoYes<1 hrRight hand paresthesia
    115MaleNoNo4 hrRight hemiparesis, dysarthria, and confusion
    1213FemaleYesNo7.5 hrLeft hand weakness and paresthesia, aphasia
    138MaleYesYes16.25 hrLeft facial weakness, hemiparesis
    1415MaleYesYes10.5 hrAphasia
    1510MaleYesNo8.5 hrAphasia and blurry vision
    164FemaleYesNo<16 hrLeft facial weakness, dysarthria
    • View popup
    Table 2:

    Radiology findings of children with ASL and SWI reported in lobes and MRA in vessels involved

    Patient No.SidepASL (Decrease)vASL (Decrease)SWI (Increase)MRA (Decrease)Resolution
    1LeftP/T/ONDF/P/T/OMCA/PCAND
    2LeftP/TNDP/TMCAYes
    3RightPNDPMCAND
    4LeftP/T/ONDP/T/ONoneYes
    5LeftF/P/T/ONDF/P/T/OACA/MCA/PCAYes
    6LeftF/P/T/OLeft F/P/O/TF/P/T/OACA/MCA/PCAND
    7LeftF/TNDF/TMCAND
    8LeftP/TNDP/TNoneND
    9LeftF/P/T/ONDF/P/T/OACA/MCAND
    10LeftNDNDP/T/OMCA/PCAND
    11LeftF/P/T/ONDF/P/T/OACA/MCA/PCAYes
    12RightF/P/T/ONDF/P/T/OACA/MCA/PCAYes
    13RightNDRight P/O/TP/T/OMCA/PCAYes
    14LeftNDNDF/P/T/OMCA/PCAND
    15LeftNDNDF/PMCAND
    16LeftNDNDP/T/OMCAND
    • Note:—pASL indicates pseudocontinuous arterial spin-labeling; vASL, velocity-selective arterial spin-labeling; ND, study not done; F, frontal; P, parietal; T, temporal; O, occipital; ACA, anterior cerebral artery; PCA, posterior cerebral artery.

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American Journal of Neuroradiology: 38 (11)
American Journal of Neuroradiology
Vol. 38, Issue 11
1 Nov 2017
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Cite this article
L.L. Lehman, A.R. Danehy, C.C. Trenor, C.F. Calahan, M.E. Bernson-Leung, R.L. Robertson, M.J. Rivkin
Transient Focal Neurologic Symptoms Correspond to Regional Cerebral Hypoperfusion by MRI: A Stroke Mimic in Children
American Journal of Neuroradiology Nov 2017, 38 (11) 2199-2202; DOI: 10.3174/ajnr.A5296

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Transient Focal Neurologic Symptoms Correspond to Regional Cerebral Hypoperfusion by MRI: A Stroke Mimic in Children
L.L. Lehman, A.R. Danehy, C.C. Trenor, C.F. Calahan, M.E. Bernson-Leung, R.L. Robertson, M.J. Rivkin
American Journal of Neuroradiology Nov 2017, 38 (11) 2199-2202; DOI: 10.3174/ajnr.A5296
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