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Research ArticlePediatric Neuroimaging

Normal Developmental Globe Morphology on Fetal MR Imaging

M.T. Whitehead and G. Vezina
American Journal of Neuroradiology September 2016, 37 (9) 1733-1737; DOI: https://doi.org/10.3174/ajnr.A4785
M.T. Whitehead
aFrom the Department of Radiology, Children's National Medical Center, Washington, DC.
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G. Vezina
aFrom the Department of Radiology, Children's National Medical Center, Washington, DC.
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  • Fig 1.
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    Fig 1.

    Receiver operating characteristic curves demonstrate sensitivity (true-positive) versus 1-specificity (false-positive) of MR imaging of the fetal brain for elliptic globe shape (X) and hyaloid vasculature visibility (diamond) as a function of age.

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    Fig 2.

    Age-related changes in globe morphology and hyaloid vasculature visibility from 17 to 39 weeks' gestation.

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    Fig 3.

    Sagittal (A) and axial (B) “fetography” T2WI (TR/TE, 5000/163 ms) of a normal fetal brain at 20 weeks' gestational age. The globe morphology is conical, with angulation of its posterior (arrows, A) and posterolateral (arrows, B) margins.

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    Fig 4.

    Sagittal (A) and axial (B) T2 HASTE (TR/TE, 1270/80 ms) of a normal fetal brain at 18 weeks' gestational age. The globe morphology is conical with angulation of its posterior (arrows, A) and posterolateral (arrows, B) margins. Follow-up sagittal (C) and axial (D) T2 HASTE (TR/TE, 1270/81 ms) of a normal fetal brain from imaging performed on the same patient at 30 weeks' gestational age. Ocular globe morphology is round/elliptic in the axial and sagittal planes. Fetal vasculature is not visible.

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    Fig 5.

    Sagittal single-shot fast spin-echo T2WI (TR/TE, 1087/56 ms) of a normal fetal brain at 19 weeks' gestation. Linear hypointense signal extending from the posterior margin of the lens through the vitreous toward the apex represents the hyaloid vasculature (arrow).

Tables

  • Figures
  • Frequency of hyaloid visibility and elliptic, transitional, nonelliptic, and combined transitional and noneliptic globe morphology at various gestational ages (16–39 weeks)

    GAFH (F)H (%)E (F)E (%)T (F)T (%)NE (F)NE (%)T + NE (F)T + NE (%)
    177686000071007100
    181698900001610016100
    1937236200003710037100
    2060132200006010060100
    2148132700004810048100
    22506120036479450100
    23282700311258928100
    241831700527137318100
    25290062118625172379
    26270011461659001659
    27380017452175002175
    284300327411600116
    2934003397130000
    30300030100000000
    3141004098120012
    32310031100000000
    33300030100000000
    34340034100000000
    35330033100000000
    36150015100000000
    37210021100000000
    388008100000000
    393003100000000
    • Note:—GA indicates gestational age in weeks; F, frequency; H, hyaloid vasculature; E, elliptic; T, transitional globe morphology/mild nonellipsoid shape; NE, nonelliptic.

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American Journal of Neuroradiology: 37 (9)
American Journal of Neuroradiology
Vol. 37, Issue 9
1 Sep 2016
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Cite this article
M.T. Whitehead, G. Vezina
Normal Developmental Globe Morphology on Fetal MR Imaging
American Journal of Neuroradiology Sep 2016, 37 (9) 1733-1737; DOI: 10.3174/ajnr.A4785

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Normal Developmental Globe Morphology on Fetal MR Imaging
M.T. Whitehead, G. Vezina
American Journal of Neuroradiology Sep 2016, 37 (9) 1733-1737; DOI: 10.3174/ajnr.A4785
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