Article Figures & Data
Figures
- Fig 1.
ROIs for diffusion MR imaging measures are shown. Left: Axial section through the auditory radiation, as defined by HARDI tractography. Right: Coronal section through the transverse gyrus (Heschl's gyrus) ROI as defined by the white matter parcellation performed by FreeSurfer.
- Fig 2.
Developmental trajectory of M100 versus age for the left and right hemispheres. Left and right control and deletion regression lines significantly decrease with age (P < .001 each). There is no significant difference in slope between the groups. Individuals with an ASD diagnosis are indicated by an asterisk. The elevated M100 latency in the deletion group can be observed in both hemispheres.
- Fig 3.
Group comparisons of auditory radiation DTI parameters are shown. The deletion group exhibits elevated AD, and both CNV groups have elevated MD. The asterisk indicates P < .05; AD, axial diffusivity.
- Fig 4.
Group comparisons of Heschl's gyrus DTI parameters are shown. The deletion group exhibits elevated RD and MD and decreased FA. The duplication group exhibits higher MD and RD along with a trend toward decreased FA. The asterisk indicates P < .05; double asterisks, P < .001; AD, axial diffusivity.
- Fig 5.
Relationships between diffusivity and M100 are shown for left and right auditory radiations. While overall there is a significant main effect (P < .05) of MD on M100 latency, post hoc analysis within groups reveals that this is only significantly resolved for right hemisphere control MD and RD (P = .017 and P = .049, respectively). Control subjects are blue, subjects with deletion are red, and subjects with duplication are green. Subjects with deletion and duplication with an ASD diagnosis are indicated by asterisks.
- Fig 6.
Relationships between diffusivity and M100 are shown for the left and right Heschl's gyri. While overall, there is a significant main effect of MD (P < .02) and RD (P < .001) on M100 latency, post hoc analysis within groups reveals that this is only significantly resolved for right hemisphere control MD and RD (P < .001, P = .002, respectively). Control subjects are blue, subjects with deletion are red, and subjects with duplication are green. Subjects with deletion and duplication with an ASD diagnosis are indicated by asterisks.
Tables
Correlation of DTI with M100 within groupsa
Auditory Radiation Heschl's Gyrus Control Deletion Duplication Control Deletion Duplication MD 16.4 14.7 1.1 29.9 1.2 24.7 P = .044b P = .3 P = .9 P < .001b P = .9 P = .2 FA −67.4 73.2 −43 −78.3 −111 −75.2 P = .15 P = .3 P = .7 P = .063 P = .2 P = .4 RD 10.6 1.3 2.3 21.7 12.8 17.4 P = .048b P = .9 P = .9 P < .001b P = .3 P = .2 AD 0.6 11.7 −1.8 2.4 −4.9 1.9 P = .9 P = .11 P = .8 P = .5 P = .4 P = .8
