Diffusion Tractography Biomarkers of Pediatric Cerebellar Hypoplasia/Atrophy: Preliminary Results Using Constrained Spherical Deconvolution

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Fig 1.
Reconstructed bundles for corticopontocerebellar (left), cerebellar-thalamic (middle), and corticospinal (right) tracts in subjects with (from top to bottom) CH, PCH, CA, and controls. Bundles are overlaid on T1-weighted images. Figures are representative of the global shape of the reconstructed bundles, irrespective of the cropping of the anatomic section.
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Fig 2.
Plots of fractional anisotropy and mean diffusivity within the corticopontocerebellar, cerebellar-thalamic, and corticospinal tracts for CH, PCH, CA, and controls.

Table 1:

Mean and SD of FA, MD, AD, and RD within the CPCT, CTT, and CST

Tract/Group	FA Mean (SD)	MD Mean (SD) (10⁻³ mm²/s)	AD Mean (SD) (10⁻³ mm²/s)	RD Mean (SD) (10⁻³ mm²/s)
CPCT
CH	0.42 (0.03)	0.98 (0.11)	1.42 (0.12)	0.76 (0.09)
PCH	0.27 (0.04)	1.14 (0.14)	1.41 (0.08)	0.99 (0.14)
CA	0.35 (0.03)	0.99 (0.03)	1.36 (0.03)	0.81 (0.04)
Control	0.44 (0.02)	0.88 (0.07)	1.37 (0.09)	0.66 (0.06)
CTT
CH	0.28 (0.03)	1.39 (0.11)	1.79 (0.09)	1.26 (0.17)
PCH	0.19 (0.03)	1.49 (0.18)	1.79 (0.23)	1.39 (0.14)
CA	0.22 (0.02)	1.59 (0.14)	1.68 (0.21)	1.41 (0.15)
Control	0.29 (0.02)	1.29 (0.17)	1.81 (0.19)	1.27 (0.21)
CST
CH	0.44 (0.02)	1.07 (0.29)	1.69 (0.16)	0.91 (0.11)
PCH	0.31 (0.03)	1.29 (0.13)	1.71 (0.19)	1.08 (0.11)
CA	0.36 (0.03)	1.06 (0.06)	1.46 (0.05)	0.86 (0.06)
Control	0.45 (0.02)	0.97 (0.04)	1.43 (0.06)	0.73 (0.04)

Table 2:

Pair-wise comparisons for averaged scalar measures of each tract