Quantitative Evaluation of Medial Temporal Lobe Morphology in Children with Febrile Status Epilepticus: Results of the FEBSTAT Study

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Fig 1.
Medial temporal lobe morphologic measurements. Linear and angular measurements, shown in red, were obtained in relation to reference lines, shown in yellow. Measurements were obtained bilaterally; right-sided measurements are omitted here for clarity. Note the presence of HIMAL in this subject. A and B, Distances of the hippocampal formation and uncus from the midline. C, Angle of the hippocampal formation. D and E, Height and width of the hippocampal formation. F, Width of the temporal horn. G, Angle of the collateral sulcus.

Table 1:

Descriptive summary of the MRI measurements

Measurement	No.	Mean	SD
Left side
Collateral sulcus angle (°)	268	61.9534	12.3098
Lateral ventricle width (cm)	285	0.3604	0.2053
Hipp angle (°)	285	174.4526	12.5996
Hipp height:width	285	0.7129	0.1106
Hipp distance from midline	285	1.5141	0.217
Right side
Collateral sulcus angle (°)	277	68.9564	9.6766
Lateral ventricle width (cm)	284	0.257	0.158
Hipp angle (°)	284	184.1936	9.0709
Hipp height:width	284	0.6862	0.0919
Hipp distance from midline	284	1.5267	0.2166

Table 2:

Association between left hippocampal quantitative morphology and HIMAL

Measurement	Cutoff	Sensitivity	Specificity	Unadjusted OR (95% CI)	P Value	Adjusted OR (95% CI)	P Value
Collateral sulcus angle (°)	56.26	0.5789	0.7355	0.26 (0.10–0.68)	.0059
Lateral ventricle width (cm)	0.53	0.8421	0.861	33.04 (9.16–119.11)	<.0001	10.59 (2.65–42.34)	.0009
Hipp angle (°)	178.37	0.8421	0.4595	0.22 (0.06–0.78)	.0184
Hipp height:width	0.75	0.6842	0.7181	5.52 (2.02–15.07)	.0009	3.69 (1.11–12.24)	.0332
Hipp distance from midline	1.42	0.8947	0.6988	0.05 (0.01–0.23)	<.0001	0.12 (0.02–0.59)	.0094

Table 3:

Association between quantitative temporal lobe morphology and FSE

Measurement	Cutoff	Sensitivity	Specificity	Unadjusted OR (95% CI)	P Value	Adjusted OR (95% CI)	P Value
Left side
Collateral sulcus angle (°)	70.68	0.3017	0.7977	1.70 (0.93–3.13)	.0858	1.73 (0.91–3.32)	.0971
Lateral ventricle width (cm)	0.17	0.8756	0.2609	2.49 (1.32–4.68)	.0048	2.79 (1.39–5.59)	.0038
Hipp angle (°)	183.66	0.8394	0.2391	0.61 (0.33–1.13)	.1133	0.62 (0.31–1.23)	.168
Hipp height:width	0.61	0.1658	0.913	0.48 (0.21–1.09)	.0781	0.46 (0.20–1.08)	.0756
Hipp distance from midline	1.51	0.4922	0.6196	1.58 (0.95–2.62)	.0774	1.69 (0.96–2.99)	.0714
Right side
Collateral sulcus angle (°)	71.35	0.4785	0.6593	1.78 (1.06–2.99)	.0305	1.87 (1.05–3.34)	.0351
Lateral ventricle width (cm)	0.20	0.6198	0.6087	2.54 (1.52–4.22)	.0003	4.56 (2.48–8.41)	<.0001
Hipp angle (°)	185.50	0.5052	0.6739	2.11 (1.26–3.55)	.0049	2.26 (1.26–4.05)	.0065
Hipp height:width	0.66	0.651	0.4891	1.79 (1.08–2.96)	.0244	2.06 (1.17–3.61)	.0119
Hipp distance from midline	1.52	0.4948	0.663	1.93 (1.15–3.23)	.0128	2.29 (1.23–4.25)	.0091

Table 4:

Association between quantitative temporal lobe morphology and FSE in visually normal subjects

Measurement	Cutoff	Sensitivity	Specificity	Unadjusted OR (95% CI)	P Value	Adjusted OR (95% CI)	P Value
Left side
Collateral sulcus angle (°)	70.65	0.3247	0.7931	1.84 (0.99–3.42)	.0529	1.83 (0.95–3.55)	.0715
Lateral ventricle width (cm)	0.17	0.8631	0.2667	2.29 (1.21–4.34)	.0113	2.61 (1.29–5.31)	.0078
Hipp angle (°)	183.66	0.8394	0.2391	0.66 (0.35–1.24)	.195	0.62 (0.30–1.28)	.1947
Hipp height:width	0.61	0.1667	0.9111	0.49 (0.21–1.12)	.0907	0.44 (0.18–1.04)	.0604
Hipp distance from midline	1.51	0.5298	0.6111	1.77 (1.05–2.98)	.0317	1.90 (1.06–3.42)	.0315
Right side
Collateral sulcus angle (°)	71.35	0.4731	0.6556	1.71 (1.01–2.904)	.0478	1.746 (0.97–3.15)	.0636
Lateral ventricle width (cm)	0.20	0.593	0.6158	2.33 (1.39–3.923)	.001	4.07 (2.18–7.58)	<.0001
Hipp angle (°)	185.49	0.5233	0.6813	2.35 (1.38–4.00)	.0049	2.43 (1.33–4.42)	.0038
Hipp height:width	0.70	0.4419	0.7033	1.88 (1.09–3.22)	.0227	1.81 (1.002–3.28)	.0494
Hipp distance from midline	1.52	0.4942	0.6593	1.89 (1.18–3.20)	.0177	2.062 (1.10–3.87)	.0245