Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain
Open Access

Exposing Hidden Truncation-Related Errors in Acute Stroke Perfusion Imaging

W.A. Copen, A.R. Deipolyi, P.W. Schaefer, L.H. Schwamm, R.G. González and O. Wu
American Journal of Neuroradiology April 2015, 36 (4) 638-645; DOI: https://doi.org/10.3174/ajnr.A4186
W.A. Copen
aFrom the Departments of Radiology (W.A.C., A.R.D., P.W.S., R.G.G., O.W.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A.R. Deipolyi
aFrom the Departments of Radiology (W.A.C., A.R.D., P.W.S., R.G.G., O.W.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P.W. Schaefer
aFrom the Departments of Radiology (W.A.C., A.R.D., P.W.S., R.G.G., O.W.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
L.H. Schwamm
bNeurology (L.H.S.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R.G. González
aFrom the Departments of Radiology (W.A.C., A.R.D., P.W.S., R.G.G., O.W.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
O. Wu
aFrom the Departments of Radiology (W.A.C., A.R.D., P.W.S., R.G.G., O.W.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

REFERENCES

  1. 1.↵
    1. Hacke W,
    2. Furlan AJ,
    3. Al-Rawi Y, et al
    . Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol 2009;8:141–50
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Parsons M,
    2. Spratt N,
    3. Bivard A, et al
    . A randomized trial of tenecteplase versus alteplase for acute ischemic stroke. N Engl J Med 2012;366:1099–107
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Ma H,
    2. Parsons MW,
    3. Christensen S, et al
    . A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND). Int J Stroke 2012;7:74–80
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Kidwell CS,
    2. Jahan R,
    3. Gornbein J, et al
    . A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med 2013;368:914–23
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Kudo K,
    2. Christensen S,
    3. Sasaki M, et al
    . Accuracy and reliability assessment of CT and MR perfusion analysis software using a digital phantom. Radiology 2013;267:201–11
    CrossRefPubMed
  6. 6.↵
    1. Ho CY,
    2. Hussain S,
    3. Alam T, et al
    . Accuracy of CT cerebral perfusion in predicting infarct in the emergency department: lesion characterization on CT perfusion based on commercially available software. Emerg Radiol 2013;20:203–12
    CrossRefPubMed
  7. 7.↵
    1. Murphy BD,
    2. Fox AJ,
    3. Lee DH, et al
    . Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements. Stroke 2006;37:1771–77
    Abstract/FREE Full Text
  8. 8.↵
    1. Chiu FY,
    2. Kao YH,
    3. Teng MM, et al
    . Validation and absolute quantification of MR perfusion compared with CT perfusion in patients with unilateral cerebral arterial stenosis. Eur J Radiol 2012;81:4087–93
    CrossRefPubMed
  9. 9.↵
    1. Calamante F,
    2. Gadian DG,
    3. Connelly A
    . Delay and dispersion effects in dynamic susceptibility contrast MRI: simulations using singular value decomposition. Magn Reson Med 2000;44:466–73
    CrossRefPubMed
  10. 10.↵
    1. Carrera E,
    2. Jones PS,
    3. Iglesias S, et al
    . The vascular mean transit time: a surrogate for the penumbra flow threshold? J Cereb Blood Flow Metab 2011;31:1027–35
    CrossRefPubMed
  11. 11.↵
    1. Schramm P,
    2. Schellinger PD,
    3. Klotz E, et al
    . Comparison of perfusion computed tomography and computed tomography angiography source images with perfusion-weighted imaging and diffusion-weighted imaging in patients with acute stroke of less than 6 hours' duration. Stroke 2004;35:1652–58
    Abstract/FREE Full Text
  12. 12.↵
    1. Deipolyi AR,
    2. Wu O,
    3. Macklin EA, et al
    . Reliability of cerebral blood volume maps as a substitute for diffusion-weighted imaging in acute ischemic stroke. J Magn Reson Imaging 2012;36:1083–87
    CrossRefPubMed
  13. 13.↵
    1. Wintermark M,
    2. Flanders AE,
    3. Velthuis B, et al
    . Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke 2006;37:979–85
    Abstract/FREE Full Text
  14. 14.↵
    1. Kamalian S,
    2. Kamalian S,
    3. Maas MB, et al
    . CT cerebral blood flow maps optimally correlate with admission diffusion-weighted imaging in acute stroke but thresholds vary by postprocessing platform. Stroke 2011;42:1923–28
    Abstract/FREE Full Text
  15. 15.↵
    1. Lansberg MG,
    2. Straka M,
    3. Kemp S, et al
    . MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study. Lancet Neurol 2012;11:860–67
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Reese TG,
    2. Heid O,
    3. Weisskoff RM, et al
    . Reduction of eddy-current-induced distortion in diffusion MRI using a twice-refocused spin echo. Magn Reson Med 2003;49:177–82
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Collins DL,
    2. Neelin P,
    3. Peters TM, et al
    . Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr 1994;18:192–205
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Rosen BR,
    2. Belliveau JW,
    3. Chien D
    . Perfusion imaging by nuclear magnetic resonance. Magn Reson Q 1989;5:263–81
    PubMed
  19. 19.↵
    1. Carroll TJ,
    2. Rowley HA,
    3. Haughton VM
    . Automatic calculation of the arterial input function for cerebral perfusion imaging with MR imaging. Radiology 2003;227:593–600
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Rempp KA,
    2. Brix G,
    3. Wenz F, et al
    . Quantification of regional cerebral blood flow and volume with dynamic susceptibility contrast-enhanced MR imaging. Radiology 1994;193:637–41
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Mouridsen K,
    2. Christensen S,
    3. Gyldensted L, et al
    . Automatic selection of arterial input function using cluster analysis. Magn Reson Med 2006;55:524–31
    CrossRefPubMed
  22. 22.↵
    1. Rausch M,
    2. Scheffler K,
    3. Rudin M, et al
    . Analysis of input functions from different arterial branches with gamma variate functions and cluster analysis for quantitative blood volume measurements. Magn Reson Imaging 2000;18:1235–43
    CrossRefPubMed
  23. 23.↵
    1. Mlynash M,
    2. Eyngorn I,
    3. Bammer R, et al
    . Automated method for generating the arterial input function on perfusion-weighted MR imaging: validation in patients with stroke. AJNR Am J Neuroradiol 2005;26:1479–86
    Abstract/FREE Full Text
  24. 24.↵
    1. Østergaard L,
    2. Weisskoff RM,
    3. Chesler DA, et al
    . High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: mathematical approach and statistical analysis. Magn Reson Med 1996;36:715–25
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Wu O,
    2. Østergaard L,
    3. Weisskoff RM, et al
    . Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix. Magn Reson Med 2003;50:164–74
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Sorensen AG,
    2. Copen WA,
    3. Østergaard L, et al
    . Hyperacute stroke: simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time. Radiology 1999;210:519–27
    CrossRefPubMedWeb of Science
  27. 27.↵
    CT Perfusion 4D User Guide. Revision 2. Milwaukee: GE Healthcare Publications; 2011
  28. 28.↵
    1. Wintermark M,
    2. Smith WS,
    3. Ko NU, et al
    . Dynamic perfusion CT: optimizing the temporal resolution and contrast volume for calculation of perfusion CT parameters in stroke patients. AJNR Am J Neuroradiol 2004;25:720–29
    Abstract/FREE Full Text
  29. 29.↵
    1. Kamena A,
    2. Streitparth F,
    3. Grieser C, et al
    . Dynamic perfusion CT: optimizing the temporal resolution for the calculation of perfusion CT parameters in stroke patients. Eur J Radiol 2007;64:111–18
    CrossRefPubMed
  30. 30.↵
    1. Abels B,
    2. Klotz E,
    3. Tomandl BF, et al
    . CT perfusion in acute ischemic stroke: a comparison of 2-second and 1-second temporal resolution. AJNR Am J Neuroradiol 2011;32:1632–39
    Abstract/FREE Full Text
  31. 31.↵
    1. Wintermark M,
    2. Albers GW,
    3. Alexandrov AV, et al
    . Acute stroke imaging research roadmap. Stroke 2008;39:1621–28
    Abstract/FREE Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 36 (4)
American Journal of Neuroradiology
Vol. 36, Issue 4
1 Apr 2015
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Exposing Hidden Truncation-Related Errors in Acute Stroke Perfusion Imaging
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
W.A. Copen, A.R. Deipolyi, P.W. Schaefer, L.H. Schwamm, R.G. González, O. Wu
Exposing Hidden Truncation-Related Errors in Acute Stroke Perfusion Imaging
American Journal of Neuroradiology Apr 2015, 36 (4) 638-645; DOI: 10.3174/ajnr.A4186

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Exposing Hidden Truncation-Related Errors in Acute Stroke Perfusion Imaging
W.A. Copen, A.R. Deipolyi, P.W. Schaefer, L.H. Schwamm, R.G. González, O. Wu
American Journal of Neuroradiology Apr 2015, 36 (4) 638-645; DOI: 10.3174/ajnr.A4186
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Detecting CTP Truncation Artifacts in Acute Stroke Imaging from the Arterial Input and the Vascular Output Functions
  • CTP: Time for Patient-Tailored Acquisition Protocols
  • Identifying Severe Stroke Patients Likely to Benefit From Thrombectomy Despite Delays of up to a Day
  • Sex-specific differences in white matter microvascular integrity after ischaemic stroke
  • Validation of MRI Determination of the Penumbra by PET Measurements in Ischemic Stroke
  • Optimal Computed Tomographic Perfusion Scan Duration for Assessment of Acute Stroke Lesion Volumes
  • Crossref (30)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • CT for Treatment Selection in Acute Ischemic Stroke: A Code Stroke Primer
    Christopher A. Potter, Achala S. Vagal, Mayank Goyal, Diego B. Nunez, Thabele M. Leslie-Mazwi, Michael H. Lev
    RadioGraphics 2019 39 6
  • Diffuse microvascular dysfunction and loss of white matter integrity predict poor outcomes in patients with acute ischemic stroke
    Natalia S Rost, Pedro Cougo, Svetlana Lorenzano, Hua Li, Lisa Cloonan, Mark JRJ Bouts, Arne Lauer, Mark R Etherton, Hasan H Karadeli, Patricia L Musolino, William A Copen, Ken Arai, Eng H Lo, Steve K Feske, Karen L Furie, Ona Wu
    Journal of Cerebral Blood Flow & Metabolism 2018 38 1
  • Validation of MRI Determination of the Penumbra by PET Measurements in Ischemic Stroke
    Wolf-Dieter Heiss, Olivier Zaro Weber
    Journal of Nuclear Medicine 2017 58 2
  • In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core?
    William A. Copen, Livia T. Morais, Ona Wu, Lee H. Schwamm, Pamela W. Schaefer, R. Gilberto González, Albert J. Yoo, Felix Schlachetzki
    PLOS ONE 2015 10 7
  • Stroke Imaging
    Shahmir Kamalian, Michael H. Lev
    Radiologic Clinics of North America 2019 57 4
  • Optimal Computed Tomographic Perfusion Scan Duration for Assessment of Acute Stroke Lesion Volumes
    Aimen S. Kasasbeh, Søren Christensen, Matus Straka, Nishant Mishra, Michael Mlynash, Roland Bammer, Gregory W. Albers, Maarten G. Lansberg
    Stroke 2016 47 12
  • Symmetric CTA Collaterals Identify Patients with Slow-progressing Stroke Likely to Benefit from Late Thrombectomy
    Robert W. Regenhardt, R Gilberto González, Julian He, Michael H. Lev, Aneesh B. Singhal
    Radiology 2022 302 2
  • Infarct Core Reliability by CT Perfusion is a Time‐Dependent Phenomenon
    Sivan‐Hoffmann R, Saban M, Buxbaum C, Srour F, Sprecher E, Eran A, Abergel E, Telman G
    Journal of Neuroimaging 2020 30 2
  • Automated Brain Perfusion Imaging in Acute Ischemic Stroke: Interpretation Pearls and Pitfalls
    Manal Nicolas-Jilwan, Max Wintermark
    Stroke 2021 52 11
  • Normative distribution of posterior circulation tissue time-to-maximum: Effects of anatomic variation, tracer kinetics, and implications for patient selection in posterior circulation ischemic stroke
    Adam E Goldman-Yassen, Matus Straka, Michael Uhouse, Seena Dehkharghani
    Journal of Cerebral Blood Flow & Metabolism 2021 41 8

More in this TOC Section

  • Multimodal CT Provides Improved Performance for Lacunar Infarct Detection
  • Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?
  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
Show more BRAIN

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire