Article Figures & Data
Figures
- Fig 1.
Schematic illustration of the dopaminergic pathway within the striatum. Dopamine is synthesized and stored in vesicles until released into the synaptic cleft in response to an action potential. After interacting with the postsynaptic dopamine receptors, dopamine is released back into the synaptic cleft, where it is actively taken up by dopamine transporters and carried into the presynaptic neuron.
- Fig 2.
Normal study findings. The axial 123I-FP-CIT DaT-SPECT image demonstrates symmetric tracer uptake in the caudate nuclei and putamina, with very low-grade, almost absent, background activity.
- Fig 3.
Axial T2-weighted MR imaging sequence in a patient with PD (A) demonstrating “smudging” of the hypointensity in the substantia nigra toward the red nucleus in the midbrain (right subtlely more marked than the left, concordant with the contralateral clinical features). It is more easily visualized in the corresponding susceptibility-weighted image (B). Axial T2*-weighted MR imaging sequence also demonstrates the “smudging” sign as shown in another patient with PD (C) (left more than right concordant with worse contralateral clinical features). The “smudging” sign is nonspecific and seen in progressive supranuclear palsy, multiple system atrophy, and corticobasal degeneration. It is a subtle sign and often not used in routine clinical practice.
- Fig 4.
On these inversion-recovery T1-weighted images in which deep gray matter signal is suppressed, the substantia nigra in a patient with severe PD (A) appears both substantially shrunk and with altered contrast in comparison with a healthy control (B). There is a correlation between the substantia nigra area with the Unified Parkinson Disease Rating Scale score.23 There is also a group difference between those with PD and controls; however, this metric has not been proved to be useful for individuals. Images courtesy of Dr Ludovico Minati, Scientific Department, Istituto Di Ricovero e Cura a Carattere Scientifico Foundation Neurologic Institute, Carlo Besta, Milan, Italy.
- Fig 5.
T2-weighted fast spin-echo MR image (A) and corresponding transcranial sonography images (B and C) of midbrain axial sections at the orbitomeatal line. B, Transcranial sonography image of the axial midbrain section in a healthy person depicting the hypoechoic midbrain (outlined) surrounded by the hyperechogenic basal cisterns. In the anatomic area of the ipsilateral substantia nigra, only small hyperechoic patches are visible (small arrows); the planimetrically measured area is <0.20 cm2. The raphe is detected as a highly echogenic, continuous line; the aqueduct is shown at the dorsal part of the midbrain. C, Transcranial sonography of a patient with Parkinson disease showing a bilateral hyperechogenic substantia nigra (area ≥0.20 cm2). Small arrows indicate the substantia nigra. Images courtesy of Dr Rita CL Fernandes, Department of Neurodegeneration at Tübingen University Hospital and Hertie Institute of Clinical Brain Research, Tübingen, Germany.
- Fig 6.
Axial 18F-DOPA PET images through the striatum. The patient with early Parkinson disease shows an asymmetric reduction in putaminal radiotracer uptake. With further disease progression, both putamina show a substantial reduction in radiotracer uptake. Images courtesy of Professor Philippe Remy, l'Hôpital Henri Mondor, Creteil, France.
- Fig 7.
Axial 123I-FP-CIT DaT-SPECT sections depicting the different patterns of abnormality seen in PD as described by Catafau and Tolosa2—type 1: asymmetric activity with reduced putaminal uptake in 1 hemisphere (A); type 2: symmetric reduction in putaminal uptake in both hemispheres (B); and type 3: virtual absence of uptake in the putamina and caudate nuclei despite high gain as demonstrated by ample background activity (C).
Tables
Clinical indications for DaT-SPECT imaging
Indications Only 1 of 3 cardinal clinical signsa with or without asymmetry 2 Signs without bradykinesia Poor response to L-dopa Lack of disease progression ↵a Cardinal signs are resting tremor, rigidity, and bradykinesia. (An alternative classification adds a fourth cardinal sign as postural instability.)
