Analysis of Hemodynamics and Aneurysm Occlusion after Flow-Diverting Treatment in Rabbit Models

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Fig 1.
Imaging, modeling, and data analysis.
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Fig 2.
Visualization of peak systole flow structures pre- and post-treatment in an incompletely occluded aneurysm (case 1, top) and in a completely occluded aneurysm (case 10, bottom). Each panel shows 20 cm/s velocity isosurfaces (top) and flow streamlines (bottom) before (left) and after (right) treatment.
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Fig 3.
Posttreatment hemodynamic variables averaged over open and occluded regions.

Table 1:

Aneurysm occlusion, geometry, and device data^{^a}

Case	Aneurysm Occlusion (%)	PPA Diameter (mm)	DPA Diameter (mm)	Device Size (mm)	Aneurysm Volume (cm³)	Aneurysm Size (cm)	Neck Size (Cm)	Neck Area (Cm²)
1	7%	3.23	3.18	3.75 × 10	0.36	1.90	0.93	0.45
2	19%	3.28	2.66	4.5 × 12	0.17	1.13	0.86	0.48
3	31%	2.96	3.94	3.75 × 10	0.13	1.20	0.79	0.34
4	41%	3.72	3.54	3.75 × 12	0.06	1.17	0.65	0.27
[5]	46%	3.47	3.11	3.50 × 12	0.12	1.31	0.60	0.22
[6]	73%	3.19	3.40	3.25 × 10	0.08	0.74	0.53	0.14
7	75%	3.41	3.89	4.75 × 10	0.19	1.43	0.61	0.30
[8]	76%	3.11	3.34	3.50 × 12	0.13	1.20	0.57	0.22
9	77%	2.86	3.79	4.75 × 10	0.03	1.49	0.64	0.31
[10]	82%	3.26	3.02	3.50 × 10	0.08	0.94	0.47	0.14
11	84%	3.97	4.18	4.00 × 10	0.20	1.33	0.61	0.25
[12]	90%	3.44	3.11	3.50 × 10	0.12	1.20	0.42	0.12
13	91%	3.07	3.58	3.50 × 12	0.32	1.42	0.70	0.34
14	91%	3.95	4.24	4.00 × 10	0.08	1.01	0.53	0.09
15	94%	3.10	3.03	4.75 × 12	0.25	1.42	0.65	0.28
16	98%	3.57	3.57	4.25 × 10	0.06	0.91	0.34	0.07
[17]	100%	3.25	3.48	4.75 × 10	0.15	1.17	0.60	0.25
18	100%	3.82	3.25	3.50 × 10	0.01	0.39	0.24	0.04
19	100%	3.70	2.50	4.25 × 10	0.03	0.62	0.30	0.07
20	100%	4.24	3.96	4.75 × 10	0.03	0.59	0.41	0.12
21	100%	3.79	3.43	4.75 × 12	0.12	1.09	0.56	0.19
22	100%	3.65	2.89	4.00 × 10	0.02	0.53	0.31	0.05
23	100%	3.53	3.79	3.50 × 12	0.07	0.74	0.63	0.17

Note:—PPA indicates proximal parent artery; DPA, distal parent artery.
↵a Cases between brackets were sacrificed before 1 week and were not included in the analysis.

Table 2:

Statistics of aneurysm geometrical data

Value	Aneurysm Volume (cm³)	Aneurysm Size (cm)	Neck Size (cm)	Neck Area (cm²)
Average over patent group	0.16	1.39	0.75	0.36
Average over occluded group	0.11	0.96	0.49	0.16
Ratio (patent/occluded)	1.41	1.44	1.54	2.25
P value	.2655	.0200^{^a}	.0015^{^a}	.0006^{^a}
AUC	0.51	0.67	0.70	0.73

Table 3:

Ratio of mean posttreatment hemodynamic variables in open-over-occluded regions^{^a}

Case	Ratio (v)	Ratio (ω)	Ratio <γ̇>
1	1.88	1.40	1.43
2	1.87	1.22	1.40
3	0.64	0.45	0.63
4	0.92	0.62	0.89
[5]	2.03	1.04	1.29
[6]	0.95	1.22	1.07
7	2.05	2.15	2.05
[8]	2.38	2.31	2.11
9	1.66	0.96	1.35
[10]	4.42	4.38	4.04
11	3.90	5.06	4.16
[12]	4.96	3.56	3.83
13	1.61	1.27	1.63
14	3.38	3.58	3.72
15	3.46	5.87	4.24
16	6.06	7.15	5.86
Mean	2.64	2.64	2.48
Mean open	1.60	1.26	1.36
Mean occluded	3.97	4.41	3.93
P value	.0139^{^b}	.0046^{^b}	.0023^{^b}

↵a Cases between brackets were sacrificed before 1 week and were not included in the analysis.
↵b Statistically significant differences (P < .05).